Genital - Female Development: Difference between revisions
mNo edit summary |
mNo edit summary |
||
Line 125: | Line 125: | ||
==External Genital== | ==External Genital== | ||
<gallery perrow=4> | |||
File:Spaulding-fig06.jpg|Fig. 6. Carnegie Embryo No. 2023, 15 mm, female. X 14. | |||
File:Spaulding-fig11.jpg|Fig. 11. Carnegie Embryo No. 2023, female | |||
File:Spaulding-fig12.jpg|Fig. 12. Carnegie Embryo No. 1750, female | |||
File:Spaulding-fig13.jpg|Fig. 13. Carnegie Embryo No. 684, female | |||
File:Spaulding-fig14.jpg|Fig. 14. Carnegie Embryo No. 194, female | |||
File:Spaulding-fig19.jpg|Fig. 19. Carnegie Embryo No. 2393, female | |||
File:Spaulding-fig20.jpg|Fig. 20. Carnegie Embryo No.1900-60a., female | |||
File:Spaulding-fig21.jpg|Fig. 21. Carnegie Embryo No. 950, female | |||
</gallery> | |||
Revision as of 22:12, 27 May 2015
Embryology - 26 Apr 2024 Expand to Translate |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
The male and female reproductive systems develop initially "indifferently", it is the product of the Y chromosome SRY gene that initially makes the "difference". The paramesonephric (Müllerian Duct) contribute the majority of female internal genital tract, while the mesonephric duct degenerates.
The mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.
There are many different issues to consider in the development of the genital system. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.
There are also currently separate pages describing Ovary Development | Oocyte Development | Uterus Development | Vagina Development | Menstrual Cycle | X Inactivation
Some Recent Findings
|
More recent papers |
---|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: female sex-determining <pubmed limit=5>female sex-determining</pubmed> |
Textbooks
- Human Embryology (2nd ed.) Larson Chapter 10 p261-306
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 13 p303-346
- Before We Are Born (5th ed.) Moore and Persaud Chapter 14 p289-326
- Essentials of Human Embryology, Larson Chapter 10 p173-205
- Human Embryology, Fitzgerald and Fitzgerald Chapter 21-22 p134-152
- Developmental Biology (6th ed.) Gilbert Chapter 14 Intermediate Mesoderm
Movies
Urogenital Sinus | Urogenital Septum |
Uterus | Female External |
Development Overview
Three main stages during development, mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.
- Differentiation of gonad (Sex determination)
- Differentiation of internal genital organs
- Differentiation of external genital organs
The 2nd and 3rd stages dependent on endocrine gonad. Reproductive development has a long maturation timecourse, begining in the embryo and finishing in puberty. (More? Puberty Development)
Gonad - Ovary
Primordial germ cell migration (mouse)
Migration 1 | Migration 2 | Migration 3 |
- Links: Ovary Development | Puberty Development
Internal Genital
Historic Images of Genital Changes
Urogenital indifferent | Urogenital female |
Fetal Week 10
Ovary | Ovary |
Uterus | Uterus |
External Genital
Molecular
- Paramesonephric duct - Wnt-7a Pax-8 expression associated with the initial stages of paramesonephric duct development
- Ovary - Notum, Phlda2, Runx-1 and Msx1 genes
Y and X Chromosomes | |
---|---|
Males | Females |
Y Chromosome
|
X Chromosome
|
X inactivation
|
Dax-1
DAX1 (NR0B1) is a nuclear receptor with a characteristic C-terminal ligand binding domain, but an atypical DNA binding domain, for review see[4] DAX1 protein is localized mainly in the nucleus and can bind to an RA responsive element (RARE).
- Links: OMIM 300473
Wnt-4
First identified in 1999 as a female specific gene[5], it has been recently shown to be an upstream regulator of Runx-1 expression.[6]
References
- ↑ <pubmed>24485832</pubmed>
- ↑ <pubmed>19906863</pubmed>
- ↑ <pubmed>19159697</pubmed>
- ↑ <pubmed>17210221</pubmed>| PMC1847396/
- ↑ <pubmed>9989404</pubmed>| Nature
- ↑ <pubmed>25645944</pubmed>| Exp Cell Res.
Reviews
<pubmed>20846260</pubmed> <pubmed>19597684</pubmed> <pubmed></pubmed>
Articles
<pubmed></pubmed> <pubmed></pubmed> <pubmed>12740945</pubmed> <pubmed></pubmed>
Search PubMed
Search Pubmed: Female Genital System Development | paramesonephric duct development | paramesonephric duct
Additional Images
Terms
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 26) Embryology Genital - Female Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Genital_-_Female_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G