Genetic risk maternal age: Difference between revisions
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Interestingly, recent studies suggest that increasing paternal age (father's age) can also have affects on childhood mortality<ref><pubmed>18437509</pubmed></ref> and neurodevelopmental outcomes.<ref><pubmed>19278291</pubmed>| [http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000040 PLoS Medicine]</ref> | Interestingly, recent studies suggest that increasing paternal age (father's age) can also have affects on childhood mortality<ref><pubmed>18437509</pubmed></ref> and neurodevelopmental outcomes.<ref><pubmed>19278291</pubmed>| [http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000040 PLoS Medicine]</ref> | ||
:Links: [[trisomy_21|Trisomy 21]] | |||
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Revision as of 09:03, 27 July 2010
Introduction
The table below shows the correlation of maternal age (mother's age) and the potential risk of human genetic abnormalities in children.
The first column shows maternal age, the second column shows the most common human chromosomal abnormality, trisomy 21 (Down syndrome), the third column shows all chromosomal abnormalities. The data below are from papers published in the 1980's.[1][2][3]
Interestingly, recent studies suggest that increasing paternal age (father's age) can also have affects on childhood mortality[4] and neurodevelopmental outcomes.[5]
- Links: Trisomy 21
References
Articles
<pubmed>19050929</pubmed>
- "We examined the association between maternal age and chromosome 21 nondisjunction by origin of the meiotic error. We analyzed data from two population-based, case-control studies: Atlanta Down Syndrome Project (1989-1999) and National Down Syndrome Project (2001-2004). Cases were live born infants with trisomy 21 and controls were infants without trisomy 21 delivered in the same geographical regions. We enrolled 1,215 of 1,881 eligible case families and 1,375 of 2,293 controls. We report four primary findings. First, the significant association between advanced maternal age and chromosome 21 nondisjunction was restricted to meiotic errors in the egg; the association was not observed in sperm or in post-zygotic mitotic errors. Second, advanced maternal age was significantly associated with both meiosis I (MI) and meiosis II (MII). For example, compared to mothers of controls, mothers of infants with trisomy 21 due to MI nondisjunction were 8.5 times more likely to be >or=40 years old than 20-24 years old at the birth of the index case (95% CI=5.6-12.9). Where nondisjunction occurred in MII, mothers were 15.1 times more likely to be >or=40 years (95% CI = 8.4-27.3). Third, the ratio of MI to MII errors differed by maternal age. The ratio was lower among women <19 years of age and those >or=40 years (2.1, 2.3, respectively) and higher in the middle age group (3.6). Lastly, we found no effect of grand-maternal age on the risk for maternal nondisjunction. This study emphasizes the complex association between advanced maternal age and nondisjunction of chromosome 21 during oogenesis."
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Cite this page: Hill, M.A. (2024, April 28) Embryology Genetic risk maternal age. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Genetic_risk_maternal_age
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