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Zebrafish Nephrogenesis Signaling

Transportive cells - occupy distinct tubule segments and are characterized by the expression of various solute transporters

multiciliated cells (MCCs) - function in fluid propulsion and are dispersed in a "salt-and-pepper" fashion within the tubule.

Model of etv5a and etv4 function in MCC patterning during Nephrogenesis Abbreviations
Interplay between retinoic acid (RA), etv5a, and Notch signaling in the renal progenitor field mediates multiciliated cell (MCC) formation during nephrogenesis.

etv5a responds downstream of RA signaling to promote MCC fate, although it is likely that etv5a is not the only target of RA in this pathway.

Conversely, Notch signaling inhibits etv5a activity to restrict MCC formation and favor transportive cell identity. In addition, etv4 promotes MCC fate, although it is not resolved if etv4 acts within renal progenitors or neighboring tissues, and whether other known MCC specification factors impact etv4 in other embryonic locales to affect pronephros development.

  • P - podocyte
  • N - neck
  • PCT - proximal convoluted tubule
  • PST - proximal straight tubule
  • DE - distal early
  • CS - corpuscle of Stannius
  • DL - distal late
  • PD - pronephric duct
  • C - cloaca
Links: Renal System - Molecular | Retinoic acid | Notch | Zebrafish Development

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Marra AN & Wingert RA. (2016). Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development. Dev. Biol. , 411, 231-245. PMID: 26827902 DOI.


Fig. 7. 1-s2.0-S0012160615301068-gr7.jpg PMID and title added to original  

Cite this page: Hill, M.A. (2024, April 23) Embryology Zebrafish nephrogenesis signaling01.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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