File:Trunk neural crest migration.jpg

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Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to organise Mouse PNS neurons

(A and B) NCC migration pathways at 9.5 dpc.

  • A - In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic and perisomitic vessels (red). Rather, most NCCs are NRP1-positive (yellow) and are channeled into the anterior sclerotome by repulsive SEMA3A signals. Accordingly, Sema3A (blue) is expressed in 2 domains, a narrow stripe in the dermomyotome adjacent to the preceding intersomitic furrow, and a broader domain in the posterior dermomyotome that extends into the posterior sclerotome.
  • B - In the absence of NRP1 signaling, intermediate wave NCCs are blind to SEMA3A (now shown in gray) and preferentially migrate alongside intersomitic blood vessels (red), similar to early wave NCCs. (C and D) Peripheral neuron position in wild-types and Nrp1-null mutants at 11.5 dpc reflects the migratory patterns of their NCC precursors.
  • C - In wild-types, sensory neurons condense into segmentally arranged dorsal root ganglia in the anterior sclerotome of the somites, while sympathetic neurons form paired, but nonsegmented primary sympathetic cords next to the dorsal aorta.
  • D - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.

Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.


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Historic Embryology - Neural Crest  
1879 Olfactory Organ | 1905 Cranial and Spinal Nerves | 1908 10 mm Peripheral | 1910 Mammal Sympathetic | 1920 Human Sympathetic | 1928 Cranial ganglia | 1939 10 Somite Embryo | 1942 Origin | 1957 Adrenal

Reference

Schwarz Q, Maden CH, Vieira JM & Ruhrberg C. (2009). Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc. Natl. Acad. Sci. U.S.A. , 106, 6164-9. PMID: 19325129 DOI.

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Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Original File: Fig. 7. http://www.pnas.org/content/106/15/6164/F7.large.jpg


Cite this page: Hill, M.A. (2024, June 14) Embryology Trunk neural crest migration.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Trunk_neural_crest_migration.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current11:21, 1 September 2009Thumbnail for version as of 11:21, 1 September 20091,280 × 963 (220 KB)S8600021 (talk | contribs)Fig. 7. Working model: SEMA3A and NRP1 control trunk NCC migration to organize PNS neurons. (A and B) NCC migration pathways at 9.5 dpc. (A) In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic a

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