File:Opioids and neural development timeline.jpg

From Embryology

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Opioids and Neural Development Timeline

Excess opioids - can inhibit and delay growth.

Opioid receptor blockade - can transiently accelerate growth.

By inhibiting maturation, opioids decelerate the pace of development among overlapping populations of neurons and glia within specific brain regions. In the absence of opioids, there is some evidence that critical periods may become abbreviated and some developmental events may have insufficient time for completion—resulting in an increased likelihood of errors. (modified from original figure legend)

Links: Abnormal Development - Drugs | neural

  Critical Period Links: critical period | abnormal development | Critical Periods table | Image - Critical Periods table | Genital | Opioids | Neural | Thalidomide | Environmental


Hauser KF & Knapp PE. (2017). Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System. Front Pediatr , 5, 294. PMID: 29410949 DOI.


© 2018 Hauser and Knapp. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Original image - Fped-05-00294-g002.jpg resized and PMID added.

Cite this page: Hill, M.A. (2024, April 21) Embryology Opioids and neural development timeline.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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