File:Model human blastocyst development.jpg

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Proposed Model for Human Embryo Development

Human embryos begin life with a set of oocyte RNAs inherited from the mother. After fertilization, a subset of maternal RNAs specific to the egg (ESSP1) must be degraded as the transition from oocyte to embryo begins embryonic genome activation (EGA).

As development continues, other RNAs are partitioned equally to each blastomere (ESSP4). At EGA, ESSP2 genes are transcribed in a cell-autonomous manner.

During the cleavage divisions, embryonic blastomeres may arrest or progress independently.

'Feature extraction' indicates the three imaging parameters for predicting successful development to the blastocyst stage: cytokinesis, the time between 1st and 2nd mitoses, and the time between 2nd and 3rd mitoses.

Legend

  • EGA - embryonic genome activation
  • ESSP - embryonic stage–specific pattern, four unique embryonic stage–specific patterns (1-4)
  • RNA - ribonucleic acid


Links: Week 1 Genome Expression | Blastocyst Day 3-6 Movie

Reference

<pubmed>20890283</pubmed>| Nat Biotechnol.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nat Biotechnol. (Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Pera RA. Nat Biotechnol. 2010 Oct 3. [Epub ahead of print] PMID 20890283), copyright (2010)

Original file name: Figure 6 Nbt.1686-F6.jpg http://www.nature.com/nbt/journal/vaop/ncurrent/fig_tab/nbt.1686_F6.html


Licensee: Mark A Hill License Date: Oct 06, 2010 License Number: 2523401420894 Publication: Nature Biotechnology Title: Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage Type Of Use: Web Site



Cite this page: Hill, M.A. (2024, April 13) Embryology Model human blastocyst development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_human_blastocyst_development.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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