File:Model for Sprouty4 and FGF in mesoderm segmentation.jpg

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Model_for_Sprouty4_and_FGF_in_mesoderm_segmentation.jpg(481 × 332 pixels, file size: 28 KB, MIME type: image/jpeg)

Model for Sprouty4 and Fibroblast Growth Factor (FGF) in Mesoderm Segmentation

A Putative Model for the role of Sprouty4 as a mediator that links the segmentation clock to the gradient of FGF signaling.

  • In the PSM - FGF signaling establishes a posterior-to-anterior gradient, which is involved in the positioning of presumptive somite boundaries.
  • Cyclic Sprouty4
    • which is controlled by the Notch segmentation clock, the mechanism of which includes negative feedback loop of Hes7,
    • may inhibit the FGF signaling possibly around the anterior border of the FGF signaling positive area
    • where the FGF signaling is close to its threshold.

Thus, the FGF signaling may be periodically inhibited by Sprouty4, by which temporal periodicity of Notch segmentation clock may be translated to spatial periodicity of the array of somites.

  • S - somite
  • PS - presumptive somite.


Links: Somitogenesis | Axial Skeleton Development | Notch | FGF

Reference

Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T & Bessho Y. (2009). Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PLoS ONE , 4, e5603. PMID: 19440349 DOI.

Copyright

Hayashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Original file name: Figure 6 Pone.0005603.g006.jpg


Cite this page: Hill, M.A. (2024, May 25) Embryology Model for Sprouty4 and FGF in mesoderm segmentation.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_for_Sprouty4_and_FGF_in_mesoderm_segmentation.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current17:06, 13 May 2011Thumbnail for version as of 17:06, 13 May 2011481 × 332 (28 KB)S8600021 (talk | contribs)==Model for Sprouty4 and FGF in mesoderm segmentation== A Putative Model for the role of Sprouty4 as a mediator that links the segmentation clock to the gradient of FGF signaling. In the PSM, FGF signaling establishes a posterior-to-anterior gradient, wh