File:Chicken- neural Wnt expression.jpg

Chicken dorsalmost expression - Wnt1 and Wnt6

(A-G) Expression of Wnt1 (A-F) and Wnt6 (G-L) in HH13 (G,J), HH14 (A,D), HH15 (H,K), HH16 (B,E), HH19 (I,L) and HH20 (C,F) chick embryo brains.

Lateral (A-C,G-I) and dorsal (D-F,J-L) views are shown; anterior points to the right.

Note the broadening of Wnt1 expression at its anterior limit between HH14 and HH16 (arrowheads, A,B,D,E).

Note expression of Wnt1 anterior to the epiphysis (arrow) and along the dorsal border of the pallium (arrowhead) at HH19 (C,F). Note the expression of Wnt6 in the evaginating pineal gland at HH19 (arrow and inset, I).

Punctate expression of Wnt6 in (G-K) is likely to be in cranial ectoderm that was not completely removed from the neural tube [63]. Scale bars represent 0.2 mm.

Abbreviations: di, diencephalon; hb, hindbrain; hy, hypothalamus; mb, midbrain; tel, telencephalon.

Original file name: Figure 1. 1749-8104-4-35-1.jpg http://www.neuraldevelopment.com/content/4/1/35/figure/F1

"The forebrain is exposed to a multitude of Wnts and Wnt inhibitors that are expressed in a highly dynamic and complex fashion, precluding simple correlative conclusions about their respective functions or signalling mechanisms. In various biological systems, Wnts are antagonised by Shh signalling. By demonstrating that Wnt4 expression in the thalamus is repressed by Shh from the ZLI we reveal an additional level of interaction between these two pathways and provide an example for the cross-regulation between patterning centres during forebrain regionalisation."

Reference

<pubmed>19732418</pubmed>Neural Dev.

Quinlan et al. Neural Development 2009 4:35 doi:10.1186/1749-8104-4-35

© 2009 Quinlan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.