Chicken Aortic Arches Movie: Difference between revisions

Latest revision as of 10:09, 29 August 2014

Embryology - 18 May 2024 Expand to Translate
Google Translate - select your language from the list shown below (this will open a new external page)
العربية \| català \| 中文 \| 中國傳統的 \| français \| Deutsche \| עִברִית \| हिंदी \| bahasa Indonesia \| italiano \| 日本語 \| 한국어 \| မြန်မာ \| Pilipino \| Polskie \| português \| ਪੰਜਾਬੀ ਦੇ \| Română \| русский \| Español \| Swahili \| Svensk \| ไทย \| Türkçe \| اردو \| ייִדיש \| Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)

<html5media height="570" width="756">File:Chicken HH21 aortic arch 01.mp4</html5media>

Click Here to play on mobile device

Time-lapse OCT sequence through a transverse section of the right lateral aortic arch at stage 21.

The movie is obtained in vivo with no embryonic intervention and during the regular cardiac cycle of the beating ventricle.

Aortic arch III and IV are visible, where aortic arch IV is towards the left.
Aortic arch II can also be seen furthest to the right, within the large pharyngeal arch 2.

Cranial is toward the right and dorsal is into the page.

Original Frame dimension was 1.5×1.5 mm. (cropped video is still 1.5mm wide)

Links: Chicken Development | Head Development | Cardiovascular System Development | Movies

Reference

<pubmed>23555940</pubmed>| PLoS One.

Copyright

© 2013 Kowalski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

doi:10.1371/journal.pone.0060271.s009 (AVI)

journal.pone.0060271.mp4 Original movie adjusted formatting, size and labelling.

@@ Line 1: / Line 1: @@
 {{Movie header}}
 {|
-| <html5media>File:Chicken HH21 aortic arch 01.mp4</html5media>
+| <html5media height="570" width="756">File:Chicken HH21 aortic arch 01.mp4</html5media>
 [[Media:Chicken HH21 aortic arch 01.mp4|'''Click Here''' to play on mobile device]]
 |-
-|}
+| [[File:Chicken HH21 aortic arch icon.jpg|thumb|left]]
+Time-lapse OCT sequence through a transverse section of the right lateral aortic arch at stage 21.
+The movie is obtained in vivo with no embryonic intervention and during the regular cardiac cycle of the beating ventricle.
+* Aortic arch III and IV are visible, where aortic arch IV is towards the left.
+* Aortic arch II can also be seen furthest to the right, within the large pharyngeal arch 2.
+Cranial is toward the right and dorsal is into the page.
+Original Frame dimension was 1.5×1.5 mm. (cropped video is still 1.5mm wide)
-===Reference===
-PLoS One. 2013;8(3):e60271. doi: 10.1371/journal.pone.0060271. Epub 2013 Mar 21.
+:'''Links:''' [[Chicken Development]] | [[Head Development]] | [[Cardiovascular System Development]] | [[Movies]]
-Critical transitions in early embryonic aortic arch patterning and hemodynamics.
-Kowalski WJ1, Dur O, Wang Y, Patrick MJ, Tinney JP, Keller BB, Pekkan K.
-Author information
-Abstract
+|}
-Transformation from the bilaterally symmetric embryonic aortic arches to the mature great vessels is a complex morphogenetic process, requiring both vasculogenic and angiogenic mechanisms. Early aortic arch development occurs simultaneously with rapid changes in pulsatile blood flow, ventricular function, and downstream impedance in both invertebrate and vertebrate species. These dynamic biomechanical environmental landscapes provide critical epigenetic cues for vascular growth and remodeling. In our previous work, we examined hemodynamic loading and aortic arch growth in the chick embryo at Hamburger-Hamilton stages 18 and 24. We provided the first quantitative correlation between wall shear stress (WSS) and aortic arch diameter in the developing embryo, and observed that these two stages contained different aortic arch patterns with no inter-embryo variation. In the present study, we investigate these biomechanical events in the intermediate stage 21 to determine insights into this critical transition. We performed fluorescent dye microinjections to identify aortic arch patterns and measured diameters using both injection recordings and high-resolution optical coherence tomography. Flow and WSS were quantified with 3D computational fluid dynamics (CFD). Dye injections revealed that the transition in aortic arch pattern is not a uniform process and multiple configurations were documented at stage 21. CFD analysis showed that WSS is substantially elevated compared to both the previous (stage 18) and subsequent (stage 24) developmental time-points. These results demonstrate that acute increases in WSS are followed by a period of vascular remodeling to restore normative hemodynamic loading. Fluctuations in blood flow are one possible mechanism that impacts the timing of events such as aortic arch regression and generation, leading to the variable configurations at stage 21. Aortic arch variations noted during normal rapid vascular remodeling at stage 21 identify a temporal window of increased vulnerability to aberrant aortic arch morphogenesis with the potential for profound effects on subsequent cardiovascular morphogenesis.
+===Reference===
-PMID 23555940
 <pubmed>23555940</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060271 PLoS One.]
@@ Line 25: / Line 30: @@
 © 2013 Kowalski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+doi:10.1371/journal.pone.0060271.s009 (AVI)
+journal.pone.0060271.mp4 Original movie adjusted formatting, size and labelling.
-journal.pone.0060271.mp4 Original movie adjusted in size and labelling.
 [[Category:MP4]][[Category:Chicken]][[Category:Cardiovascular]]