File:Mouse pancreas cell lineage.jpg
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Lineage-diagram of pancreas development
The following cell types were collected: E11 and E15 pancreatic progenitors, E15 acinar cells, E15 endocrine progenitors (EP), E15, E17, P1, P15, 8–12 week beta cells, P1 and 8–12 week alpha cells, and adult duct cells.
- Neurog3 - Neurogenin-3 protein encoded in humans by the NEUROG3 gene. A basic helix-loop-helix (bHLH) transcription factor expressed in pancreas endocrine progenitor cells. This factor family involved in neural precursor cell determination in the neuroectoderm.
- CD133 - Prominin-1 a glycoprotein encoded in humans by the PROM1 gene.
- CD24 - Cluster of differentiation 24 or heat stable antigen CD24 (HSA) a protein encoded in humans by the CD24 gene. CD24 is a cell adhesion molecule.
- CD49f - Integrin alpha-6 (ITGA6) protein encoded in humans by the ITGA6 gene. Associates with a beta protein to form a laminin-binding heterodimers involved in adhesion.
- Links: Endocrine Pancreas | Exocrine Pancreas
Reference
<pubmed>25330008</pubmed>
Benitez CM, Qu K, Sugiyama T, Pauerstein PT, Liu Y, Tsai J, et al. (2014) An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development. PLoS Genet 10(10): e1004645. doi:10.1371/journal.pgen.1004645
Copyright
© 2014 Benitez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal.pgen.1004645.g001.png Panel B cropped from full figure.
Cite this page: Hill, M.A. (2024, June 15) Embryology Mouse pancreas cell lineage.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_pancreas_cell_lineage.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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