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Embryos Reprogram their Epigenetics
Two recent studies show that after fertilisation human embryos loose DNA methylation from most of the genome. This implies that there is an early "reprogramming" or "resetting" of the embryo's epigenetic status.
- The DNA methylation landscape of human early embryos PMID 25079557 "We show that the major wave of genome-wide demethylation is complete at the 2-cell stage, contrary to previous observations in mice. Moreover, the demethylation of the paternal genome is much faster than that of the maternal genome, and by the end of the zygotic stage the genome-wide methylation level in male pronuclei is already lower than that in female pronuclei."
- DNA methylation dynamics of the human preimplantation embryo PMID 25079558 "our data confirm that paternal genome demethylation is a general attribute of early mammalian development that is characterized by distinct modes of epigenetic regulation."
- (More? Epigenetics | Nature. 2014 Jul PMID 25079558 PMID 25079557)
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