2009 Lecture 21
Late Cardiovascular Development
Introduction
In lecture 7 - Early Vascular Development, there was an introduction to the origins of the cardiovascular system. This second lecture will now focus on the extensive remodeling that occurs in both the heart and vascular system during later development. In addition there will be discussion on the major cardiovascular abnormalities.
The laboratory this week will also give you the opportunity to work through some of these concepts using a new online teaching module.
Lecture Objectives
- Describe the development of primary and secondary atrial septa and the ventricular septum.
- Explain the changes occurring in the bulbis cordis and truncus arteriosus in its transformation from a single to a double tube.
- Describe the development of the aortic arches on the right and left sides from the fetus to the adult.
- Describe the development of arteries and veins.
- Describe the major cardiovascular developmental abnormalities.
Textbook references
- Human Embryology (3rd ed.) Larson Chapter 7 p151-188 Heart, Chapter 8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Chapter 14: p304-349
Other textbooks
- Before we Are Born (5th ed.) Moore and Persaud Chapter 12; p241-254
- Essentials of Human Embryology Larson Chapter 7 p97-122 Heart, Chapter 8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Chapter 13-17: p77-111
Recent reviews
- Yutzey KE, Kirby ML. Wherefore heart thou? Embryonic origins of cardiogenic mesoderm. Dev Dyn. 2002 Mar;223(3):307-20. Review. PMID: 11891982
- Three-dimensional reconstruction of gene expression patterns during cardiac development. Soufan AT, Ruijter JM, van den Hoff MJ, de Boer PA, Hagoort J, Moorman AF. Physiol Genomics. 2003 May 13;13(3):187-95. Review. PMID: 12746463
- Moorman A, Webb S, Brown NA, Lamers W, Anderson RH. Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart. 2003 Jul;89(7):806-14. PMID: 12807866
- Bruneau BG. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res. 2002 Mar 22;90(5):509-19. Review. PMID: 11909814
Abnormalities
Atrial Septal Defects
Atrial Septal Defect |
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Ventricular Septal Defects
Ventricular Septal Defect |
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(V.S.D.)
Patent Ductus Arteriosus
Patent Ductus Arteriosus | Patent Ductus Arteriosus (P.D.A.) occurs commonly in preterm infants, can close spontaneously (by day three in 60% of normal term neonates) the remainder are ligated simply and with little risk. The operation is always recommended even in the absence of cardiac failure and can often be deferred until early childhood. |
Tetralogy of Fallot
Tetralogy of Fallot | Named after Etienne-Louis Arthur Fallot (1888) who described it as "la maladie blue" and is a common developmental cardiac defect. The syndrome consists of a number of a number of cardiac defects possibly stemming from abnormal neural crest migration. |
Heart Development Movies
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Course Content 2009
Embryology Introduction | Cell Division/Fertilization | Cell Division/Fertilization | Week 1&2 Development | Week 3 Development | Lab 2 | Mesoderm Development | Ectoderm, Early Neural, Neural Crest | Lab 3 | Early Vascular Development | Placenta | Lab 4 | Endoderm, Early Gastrointestinal | Respiratory Development | Lab 5 | Head Development | Neural Crest Development | Lab 6 | Musculoskeletal Development | Limb Development | Lab 7 | Kidney | Genital | Lab 8 | Sensory - Ear | Integumentary | Lab 9 | Sensory - Eye | Endocrine | Lab 10 | Late Vascular Development | Fetal | Lab 11 | Birth, Postnatal | Revision | Lab 12 | Lecture Audio | Course Timetable
Cite this page: Hill, M.A. (2024, June 26) Embryology 2009 Lecture 21. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2009_Lecture_21
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G