Embryology History - Shinya Yamanaka
Introduction
Draft Page
- Links: Induced Stem Cells | Stem Cells
Some Recent Findings
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka
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Recent References | References
Research History
- 1987 - M.D. at Kobe University, worked as a resident in orthopedic surgery at National Osaka Hospital for two years.
- 1993 - Ph.D. in medicine at Osaka City University and moved to the United States as a postdoctoral fellow at the Gladstone Institute of Cardiovascular Disease, in San Francisco, CA.
- 1996 - Assistant professor at Osaka City University School of Medicine.
- 1999 - Associate professor at the Nara Institute of Science and Technology.
- 2004 - Professor at Kyoto University.
(text edited from 2009 interview)
Yamanaka Factors
Yamanaka Factors[1][2] Are a set of 4 transcription factors when introduced into cells induces stem cell formation. These four transcription factors can be expressed from doxycycline (dox)-inducible lentiviral vectors.
OCT4
- Transcription factors containing the POU homeodomain
- Links: OMIM - OCT4
SOX2
- Sry-related HMG-Box gene 2
- Links: OMIM - SOX2
KLF4
- Kruppel-like factor 4, zinc finger protein, transcription factor which acts as both an activator and repressor.
- Links: OMIM - KLF4
cMyc
- The MYC protooncogene encodes a DNA-binding factor that can activate and repress transcription.
- Ectopic expression of c-Myc can also cause tumorigenicity in offspring.
- Links: OMIM - MYC
- More recently shown that Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells.[3]
- Tbx3 transcription factor significantly improves the quality of iPS cells.[4]
References
Reviews
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Articles
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Journal of Visualized Experiments - Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4
Search PubMed
Search PubMed Now: ** Yamanaka+S | induced pluripotent stem cell |
External Links
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Cite this page: Hill, M.A. (2024, June 19) Embryology Embryology History - Shinya Yamanaka. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Embryology_History_-_Shinya_Yamanaka
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G