Lymph Node Development: Difference between revisions
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* '''Lymph sacs are not required for the initiation of lymph node formation'''<ref><pubmed>19060331</pubmed></ref> "As proposed by Florence Sabin more than a century ago and recently validated, the mammalian lymphatic vasculature has a venous origin and is derived from primitive lymph sacs scattered along the embryonic body axis. Also as proposed by Sabin, it has been generally accepted that lymph nodes originate from those embryonic primitive lymph sacs. However, we now demonstrate that the initiation of lymph node development does not require lymph sacs." | * '''Lymph sacs are not required for the initiation of lymph node formation'''<ref><pubmed>19060331</pubmed></ref> "As proposed by Florence Sabin more than a century ago and recently validated, the mammalian lymphatic vasculature has a venous origin and is derived from primitive lymph sacs scattered along the embryonic body axis. Also as proposed by Sabin, it has been generally accepted that lymph nodes originate from those embryonic primitive lymph sacs. However, we now demonstrate that the initiation of lymph node development does not require lymph sacs." | ||
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==Adult Lymph Node== | |||
[[File:Lymph_node_structure.jpg|thumb]] | |||
[http://www.ncbi.nlm.nih.gov/books/NBK27092/figure/A47 Immunobiology - Figure 1.8. Organization of a lymph node] | |||
[http://www.ncbi.nlm.nih.gov/books/NBK26921/figure/A4444 MBoC Figure 24-16. A simplified drawing of a human lymph node] | |||
* Encapsulated organ (1 mm - 2 cm) | |||
* In lymph vessel pathways “filter” | |||
* Afferent- towards node | |||
* Efferent- away from node | |||
* Location throughout the entire body - Concentrated in axilla, groin, mesenteries | |||
* Antigen transformed lymphocytes from the blood | |||
==Adult Lymphocytes== | ==Adult Lymphocytes== | ||
Revision as of 12:19, 22 February 2011
Introduction
Lymphatic vasculature drains lymph fluid from the organ tissue space and returns it to the blood vasculature for recirculation. Lymph nodes lie on the path of lymph vessels and these structures monitor and carry out immune surveillance of this fluid for antigens and pathogens, trapping them within the lymph nodes and generating immune responses.
Some Recent Findings
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Adult Lymph Node
Immunobiology - Figure 1.8. Organization of a lymph node
MBoC Figure 24-16. A simplified drawing of a human lymph node
- Encapsulated organ (1 mm - 2 cm)
- In lymph vessel pathways “filter”
- Afferent- towards node
- Efferent- away from node
- Location throughout the entire body - Concentrated in axilla, groin, mesenteries
- Antigen transformed lymphocytes from the blood
Adult Lymphocytes
The following data is from a recent article[2] and review[3] of live adult mouse lymphocytes (T and B cells) imaged within a lymph node.
Both lymphocyte types:
- Spend 8 to 24 h in the lymph node interstitium.
- Transit across a lymphatic endothelium to exit.
- Enter a network of medullary sinuses.
- Drain from sinuses into efferent lymphatic vessels.
Lymphocyte Migration Speeds
T cells - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min. (move more slowly in the medullary region near the hilus of the lymph node than in the paracortex)
B cells - 6 μm/min in the follicle diffuse cortex, peak velocities up to 20 μm/min.
Both cortical T cells and follicular B cells move in random directions following "guide cells".
Lymphocyte Guide Cells
FDC - Follicular Dendritic Cells, may guide B cells in the follicle.
FRC - Fibroblastic Reticular Cells, may guide T cells in the follicle.
References
Reviews
<pubmed></pubmed>
Articles
<pubmed></pubmed>
Glossary Links
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Cite this page: Hill, M.A. (2026, April 7) Embryology Lymph Node Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Lymph_Node_Development
- © Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
