Lymph Node Development: Difference between revisions

Revision as of 12:09, 22 February 2011

Introduction

Lymphatic vasculature drains lymph fluid from the organ tissue space and returns it to the blood vasculature for recirculation. Lymph nodes lie on the path of lymph vessels and these structures monitor and carry out immune surveillance of this fluid for antigens and pathogens, trapping them within the lymph nodes and generating immune responses.

Historic Embryology
1909 Lymph glands \| 1912 Development of the Lymphatic System \| 1918 Gray's Lymphatic Images \| 1916 Pig Lymphatics \| 1919 Chicken Lymphatic \| 1921 Spleen \| 1922 Pig Stomach Lymphatics \| 1932 Cat Pharyngeal Tonsil \| Historic Disclaimer

Some Recent Findings

Lymph sacs are not required for the initiation of lymph node formation^[1] "As proposed by Florence Sabin more than a century ago and recently validated, the mammalian lymphatic vasculature has a venous origin and is derived from primitive lymph sacs scattered along the embryonic body axis. Also as proposed by Sabin, it has been generally accepted that lymph nodes originate from those embryonic primitive lymph sacs. However, we now demonstrate that the initiation of lymph node development does not require lymph sacs."

Adult Lymphocytes

The following data is from a recent article^[2] and review^[3] of live adult mouse lymphocytes (T and B cells) imaged within a lymph node.

Both lymphocyte types:

Spend 8 to 24 h in the lymph node interstitium.
Transit across a lymphatic endothelium to exit.
Enter a network of medullary sinuses.
Drain from sinuses into efferent lymphatic vessels.

Lymphocyte Migration Speeds

T cells - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min. (move more slowly in the medullary region near the hilus of the lymph node than in the paracortex)

B cells - 6 μm/min in the follicle diffuse cortex, peak velocities up to 20 μm/min.

Both cortical T cells and follicular B cells move in random directions following "guide cells".

Lymphocyte Guide Cells

FDC - Follicular Dendritic Cells, may guide B cells in the follicle.

FRC - Fibroblastic Reticular Cells, may guide T cells in the follicle.

References

↑ <pubmed>19060331</pubmed>
↑ <pubmed>16273098</pubmed>
↑ <pubmed>18173372</pubmed>

Reviews

Articles

Glossary Links

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Cite this page: Hill, M.A. (2026, April 7) Embryology Lymph Node Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Lymph_Node_Development

What Links Here?

[1] <pubmed>19060331</pubmed>

[2] <pubmed>16273098</pubmed>

[3] <pubmed>18173372</pubmed>

[1]

[2]

[3]

@@ Line 23: / Line 23: @@
 ===Lymphocyte Migration Speeds===
-'''T cells''' - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min.
+'''T cells''' - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min. (move more slowly in the medullary region near the hilus of the lymph node than in the paracortex)
 '''B cells''' - 6 μm/min in the follicle diffuse cortex, peak velocities up to 20 μm/min.