Lymph Node Development: Difference between revisions
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* '''Lymph sacs are not required for the initiation of lymph node formation'''<ref><pubmed>19060331</pubmed></ref> "As proposed by Florence Sabin more than a century ago and recently validated, the mammalian lymphatic vasculature has a venous origin and is derived from primitive lymph sacs scattered along the embryonic body axis. Also as proposed by Sabin, it has been generally accepted that lymph nodes originate from those embryonic primitive lymph sacs. However, we now demonstrate that the initiation of lymph node development does not require lymph sacs." | * '''Lymph sacs are not required for the initiation of lymph node formation'''<ref><pubmed>19060331</pubmed></ref> "As proposed by Florence Sabin more than a century ago and recently validated, the mammalian lymphatic vasculature has a venous origin and is derived from primitive lymph sacs scattered along the embryonic body axis. Also as proposed by Sabin, it has been generally accepted that lymph nodes originate from those embryonic primitive lymph sacs. However, we now demonstrate that the initiation of lymph node development does not require lymph sacs." | ||
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==Adult Lymphocytes== | |||
The following data is from a recent article and review of live adult mouse lymphocytes imaged within a lymph node. | |||
===Lymphocyte Migration Speeds=== | |||
'''T cells''' - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min. | |||
'''B cells''' - 6 μm/min in the follicle diffuse cortex, peak velocities up to 20 μm/min. | |||
Both cortical T cells and follicular B cells move in random directions following "guide cells". | |||
===Lymphocyte Guide Cells=== | |||
'''FDC''' - Follicular Dendritic Cells, may guide B cells in the follicle. | |||
'''FRC''' - Fibroblastic Reticular Cells, may guide T cells in the follicle. | |||
==References== | ==References== | ||
Revision as of 12:54, 22 February 2011
Introduction
Lymphatic vasculature drains lymph fluid from the organ tissue space and returns it to the blood vasculature for recirculation. Lymph nodes lie on the path of lymph vessels and these structures monitor and carry out immune surveillance of this fluid for antigens and pathogens, trapping them within the lymph nodes and generating immune responses.
Some Recent Findings
|
Adult Lymphocytes
The following data is from a recent article and review of live adult mouse lymphocytes imaged within a lymph node.
Lymphocyte Migration Speeds
T cells - 10–12 μm/min in the follicle diffuse cortex, peak velocities up to 30 μm/min.
B cells - 6 μm/min in the follicle diffuse cortex, peak velocities up to 20 μm/min.
Both cortical T cells and follicular B cells move in random directions following "guide cells".
Lymphocyte Guide Cells
FDC - Follicular Dendritic Cells, may guide B cells in the follicle.
FRC - Fibroblastic Reticular Cells, may guide T cells in the follicle.
References
- ↑ <pubmed>19060331</pubmed>
Reviews
<pubmed>18173372</pubmed>
Articles
<pubmed>16273098</pubmed>
Glossary Links
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Cite this page: Hill, M.A. (2026, March 20) Embryology Lymph Node Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Lymph_Node_Development
- © Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
