Primordial Germ Cell Development: Difference between revisions
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Study has recently identified 11 genes that are specifically expressed in male and female fetal germ cells, both in vivo and in vitro, but are not expressed in embryonic stem cells.<ref><pubmed>20940145</pubmed></ref> | Study has recently identified 11 genes that are specifically expressed in male and female fetal germ cells, both in vivo and in vitro, but are not expressed in embryonic stem cells.<ref><pubmed>20940145</pubmed></ref> | ||
'''PGC Markers:''' alkaline phosphatase-positive, Oct4, Fragilis (IFITM1), Stella (DPPA3), Dazl, and Vasa (DDX4). | '''PGC Markers:''' alkaline phosphatase-positive, Oct4 (POU5F1), Fragilis (IFITM1), Stella (DPPA3), Dazl, and Vasa (DDX4). | ||
* '''Steel factor''' | * '''Steel factor''' | ||
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:'''Links:''' [http://www.ncbi.nlm.nih.gov/omim/601486 OMIM - DAZL] | [http://www.ncbi.nlm.nih.gov/omim/608408 OMIM - DPPA3] | [http://www.ncbi.nlm.nih.gov/omim/604456 OMIM - IFITM1] | [http://www.ncbi.nlm.nih.gov/omim/605281 OMIM - DDX4] | :'''Links:''' [http://www.ncbi.nlm.nih.gov/omim/164177 OMIM - POU5F1] | [http://www.ncbi.nlm.nih.gov/omim/601486 OMIM - DAZL] | [http://www.ncbi.nlm.nih.gov/omim/608408 OMIM - DPPA3] | [http://www.ncbi.nlm.nih.gov/omim/604456 OMIM - IFITM1] | [http://www.ncbi.nlm.nih.gov/omim/605281 OMIM - DDX4] | ||
==Abnormalities== | ==Abnormalities== |
Revision as of 00:02, 19 November 2010
Introduction
Early in development at the time of gastrulation a small group of cells are "put aside" to later form oocytes and spermatozoa. This population of cells is described as the primordial germ cells (PGCs). These cells also migrate initially into the posterior endoderm that forms the hindgut and from there into the genital ridge that will be the site of the developing gonad. The maintenance of pluripotency within this cell population may arise through epigenetic modifications that suppress somatic differentiation programs.
This population of cells when transformed is also thought to give rise to testicular germ cell tumours.
Some Recent Findings
|
Textbooks
- Human Embryology (2nd ed.) Larson Chapter 10 p261-306
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 13 p303-346
- Before We Are Born (5th ed.) Moore and Persaud Chapter 14 p289-326
- Essentials of Human Embryology, Larson Chapter 10 p173-205
- Human Embryology, Fitzgerald and Fitzgerald Chapter 21-22 p134-152
- Developmental Biology (6th ed.) Gilbert Chapter 14 Intermediate Mesoderm
Primordial Germ Cell Migration
Species Comparison of Migration
Stages of primordial germ cell migration[4]
Mouse Migration Movies
Migration 1 | Migration 2 | Migration 3 |
Molecular
Study has recently identified 11 genes that are specifically expressed in male and female fetal germ cells, both in vivo and in vitro, but are not expressed in embryonic stem cells.[5]
PGC Markers: alkaline phosphatase-positive, Oct4 (POU5F1), Fragilis (IFITM1), Stella (DPPA3), Dazl, and Vasa (DDX4).
- Steel factor
- DAZL
- dead end - coding an RNA binding protein mainly expressed in the germ cells of vertebrates.
- Blimp1 - B-Lymphocyte induced maturation protein-1 (PRDM1)
- Prmt5 - protein arginine methyltransferase-5
- Nanog - knockdown induces apoptotic cell death in mouse migrating primordial germ cells.[6]
- Links: OMIM - POU5F1 | OMIM - DAZL | OMIM - DPPA3 | OMIM - IFITM1 | OMIM - DDX4
Abnormalities
Testicular germ cell tumours
References
Reviews
<pubmed>20371640</pubmed> <pubmed>19875497</pubmed> <pubmed>19442193</pubmed> <pubmed>17446386</pubmed> <pubmed>15666347</pubmed> <pubmed>11565804</pubmed> <pubmed>11061420</pubmed>
Articles
Search PubMed
Search Pubmed: Primordial Germ Cell Migration | Primordial Germ Cell | Testicular germ cell tumours
Terms
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, June 16) Embryology Primordial Germ Cell Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Primordial_Germ_Cell_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G