Template:Main Page News: Difference between revisions
From Embryology
mNo edit summary |
mNo edit summary |
||
Line 1: | Line 1: | ||
{| width= | {| width=100%| | ||
|-bgcolor="CEDFF2" | |-bgcolor="CEDFF2" | ||
| <span style="font-size:150%">'''News - Thalidomide Molecular Mechanism shown in Zebrafish</span> | | <span style="font-size:150%">'''News - Thalidomide Molecular Mechanism shown in Zebrafish</span> |
Revision as of 14:43, 17 June 2016
News - Thalidomide Molecular Mechanism shown in Zebrafish |
PMID 27294876 | Nat Med. Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 (also known as Basigin) a member of the immunoglobulin superfamily). Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure. |
|