2009 Lecture 5

Endoderm Development

Introduction

We have seen the following processes during early human development so far: fertilization and blastocyst development in the first week, implantation in the second week, early placentation and bilaminar to trilaminar in the third week. In the third to fourth week we will now follow the development of the trilaminar embryo as each layer begins to differentiate into the primordia of different tissues within the embryo. From this point onward the lectures will not be in a strict timeline format as we will have to follow each layer (ectoderm, mesoderm, endoderm) forward through its early development, and then jump back to discuss the next layer.

This lecture will look at mesoderm development and formation of the body cavities.

Objectives

• Understanding of events during the third week of development
• Understanding the process of notochord formation
• Understanding the process of early somite development
• Understanding the process of body cavity formation
• Understanding the future fate of mesoderm components
• Brief understanding of early heart formation

UNSW Embryology Links

• Mesoderm Slides Mesoderm Lecture 2008 - 1 slide/page | Lecture 3 2008 Slides - 4 slides/page | Mesoderm Lecture 2008 Slides - 6 slides/page

• Mesoderm Week 4 Movies | Mesoderm Movies |
• Mesoderm Notes Week 4 | Week 4 - Somites | Coelomic Cavity Development | Musculoskeletal Development |

References

Textbooks

• The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Ch15,16: p405-423, 426-430
• Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Ch11 p311-339
• Before We Are Born (5th ed.) Moore and Persaud Ch16,17: p379-397, 399-405
• Essentials of Human Embryology Larson Ch11 p207-228
• Human Embryology and Developmental Biology ?Carlson Ch9,10: p173-193, 209-222

Online Textbooks

• Developmental Biology by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000 Figure 11.22. The cleavage of a single mouse embryo in vitro | Figure 11.25. Mouse blastocyst hatching from the zona pellucida | Figure 11.20. Development of a human embryo from fertilization to implantation | Figure 11.24. Implantation of the mammalian blastocyst into the uterus
• Molecular Biology of the Cell 4th ed. Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 - Fertilization | Figure 21-84. Scanning electron micrographs of the early mouse embryo | Figure 21-69. The blastula
• Molecular Cell Biology by Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E. New York: W. H. Freeman & Co.; c1999 Chapter 13. Regulation of the Eukaryotic Cell Cycle
• The Cell - A Molecular Approach by Cooper, Geoffrey M. Sunderland (MA): Sinauer Associates, Inc.; c2000 Figure 14.37. Meiosis of vertebrate oocytes
• HSTAT - In Vitro Fertilization As A Medical Treatment For Male or Female Infertility
• Human Molecular Genetics 2 Strachan, Tom and Read, Andrew P. New York and London: Garland Science; c1999 Figure 8.19. Changes in DNA methylation during mammalian development

Search

• Bookshelf blastocyst | morula | implantation | ectopic pregnancy

• Pubmed blastocyst | implantation | ectopic pregnancy |

UNSW Embryology Links

• Lecture 5 2008
• System Notes
• Development Timeline

Glossary Links

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Next Lecture

Lecture 6 | Course Timetable

Dr Mark Hill 2009 UNSW CRICOS Provider Code No. 00098G