2009 Lecture 5: Difference between revisions

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=Endoderm Development=
=Endoderm Development=
== Introduction ==
== Introduction ==
Following fertilization the first two weeks the implanted conceptus now begins to develop both embryonic cell layers and an early placenta.
We have seen the following processes during early human development so far: fertilization and blastocyst development in the first week, implantation in the second week, early placentation and bilaminar to trilaminar in the third week. In the third to fourth week we will now follow the development of the trilaminar embryo as each layer begins to differentiate into the primordia of different tissues within the embryo. From this point onward the lectures will not be in a strict timeline format as we will have to follow each layer ('''ectoderm, mesoderm, endoderm''') forward through its early development, and then jump back to discuss the next layer.
 
 
 
== Objectives ==
 
* Understanding of events during the third week of development
* Understanding the process of notochord formation
* Understanding the process of early somite development
* Understanding the process of body cavity formation
* Understanding the future fate of mesoderm components
* Brief understanding of early heart formation
 
 
==UNSW Embryology Links==
 
* '''Mesoderm Slides''' [http://embryology.med.unsw.edu.au/pdf/ANAT2341L6Mesoderms1.pdf Mesoderm Lecture 2008 - 1 slide/page ] | [http://embryology.med.unsw.edu.au/pdf/ANAT2341L6Mesoderms4.pdf Lecture 3 2008 Slides - 4 slides/page] | [http://embryology.med.unsw.edu.au/pdf/ANAT2341L6Mesoderms6.pdf LMesoderm Lecture 2008 Slides - 6 slides/page]
 
* '''Mesoderm''' [http://embryology.med.unsw.edu.au/Movies/week4.htm Week 4 Movies] | [http://embryology.med.unsw.edu.au/Movies/mesoderm.htm Mesoderm Movies] |
* '''Mesoderm Notes''' [http://embryology.med.unsw.edu.au/Notes/week4.htm Week 4] | [http://embryology.med.unsw.edu.au/Notes/week4_4.htm Week 4 - Somites] | [http://embryology.med.unsw.edu.au/Notes/skmus.htm Musculoskeletal Development] |
 
 
== References ==
===Textbooks===
* '''The Developing Human: Clinically Oriented Embryology''' (8th Edition) by Keith L. Moore and T.V.N Persaud - Ch15,16: p405-423, 426-430
* '''Larsen’s Human Embryology''' by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West -  Ch11 p311-339
* Before We Are Born (5th ed.) Moore and Persaud Ch16,17: p379-397, 399-405
* Essentials of Human Embryology Larson Ch11 p207-228
* Human Embryology and Developmental Biology ?Carlson Ch9,10: p173-193, 209-222
 
===Online Textbooks===
* '''Developmental Biology''' by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.2615 Figure 11.22. The cleavage of a single mouse embryo in vitro] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.2618 Figure 11.25. Mouse blastocyst hatching from the zona pellucida] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=implantation&rid=dbio.figgrp.2612 Figure 11.20. Development of a human embryo from fertilization to implantation] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=blastocyst&rid=dbio.figgrp.2617 Figure 11.24. Implantation of the mammalian blastocyst into the uterus]
* '''Molecular Biology of the Cell''' 4th ed. Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 -  [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.section.3738 Fertilization] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.figgrp.3955 Figure 21-84. Scanning electron micrographs of the early mouse embryo] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.figgrp.3927 Figure 21-69. The blastula]
* '''Molecular Cell Biology''' by Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E. New York: W. H. Freeman & Co.; c1999 Chapter 13. Regulation of the Eukaryotic Cell Cycle
* '''The Cell - A Molecular Approach''' by Cooper, Geoffrey M. Sunderland (MA): Sinauer Associates, Inc.; c2000  [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=cooper.figgrp.2492 Figure 14.37. Meiosis of vertebrate oocytes]
* '''HSTAT''' - [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=hstat6.section.1395#1396 In Vitro Fertilization As A Medical Treatment For Male or Female Infertility]
* '''Human Molecular Genetics 2''' Strachan, Tom and Read, Andrew P. New York and London: Garland Science; c1999 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=morula&rid=hmg.figgrp.928 Figure 8.19. Changes in DNA methylation during mammalian development]
 
===Search ===
 
* '''Bookshelf'''  [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=blastocyst blastocyst] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=morula morula] |  [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=implantation implantation] | [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=ectopic_pregnancy ectopic pregnancy]
 
* '''Pubmed''' [http://www.ncbi.nlm.nih.gov/sites/gquery?itool=toolbar&cmd=search&term=blastocyst blastocyst] | [http://www.ncbi.nlm.nih.gov/sites/gquery?itool=toolbar&cmd=search&term=implantation implantation] | [http://www.ncbi.nlm.nih.gov/sites/gquery?itool=toolbar&cmd=search&term=ectopic_pregnancy ectopic pregnancy] |
 
==UNSW Embryology Links==
==UNSW Embryology Links==
* [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture05.htm Lecture 5 2008]
* [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture05.htm Lecture 5 2008]

Revision as of 07:55, 9 August 2009

Endoderm Development

Introduction

We have seen the following processes during early human development so far: fertilization and blastocyst development in the first week, implantation in the second week, early placentation and bilaminar to trilaminar in the third week. In the third to fourth week we will now follow the development of the trilaminar embryo as each layer begins to differentiate into the primordia of different tissues within the embryo. From this point onward the lectures will not be in a strict timeline format as we will have to follow each layer (ectoderm, mesoderm, endoderm) forward through its early development, and then jump back to discuss the next layer.


Objectives

  • Understanding of events during the third week of development
  • Understanding the process of notochord formation
  • Understanding the process of early somite development
  • Understanding the process of body cavity formation
  • Understanding the future fate of mesoderm components
  • Brief understanding of early heart formation


UNSW Embryology Links


References

Textbooks

  • The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Ch15,16: p405-423, 426-430
  • Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Ch11 p311-339
  • Before We Are Born (5th ed.) Moore and Persaud Ch16,17: p379-397, 399-405
  • Essentials of Human Embryology Larson Ch11 p207-228
  • Human Embryology and Developmental Biology ?Carlson Ch9,10: p173-193, 209-222

Online Textbooks

Search

UNSW Embryology Links

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