Corpus Luteum Development: Difference between revisions
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===Progesterone=== | ===Progesterone=== | ||
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| In 1934 progesterone (progestin) was first isolated from the {{corpus luteum}} and its structure reported by four separate groups of researchers.<ref name=Butenandt1934>Butenandt A. Neure Ergebnisse auf dem Gebiet der Sexualhormone. Wien Klin Wochenschr. 1934;47:936.</ref><ref name=Slotta1934>Slotta KH, Ruschig H, Fels E. Ȕber der Hormon aus dem Corpus-luteum. Ber Chem Ges. 1934;67:1270.</ref><ref name=Hartmann1934>Hartmann M, Wettstein A. Ein krystallisiertes Hormon aus Corpus-luteum. Helv Chim Acta. 1934;17:878.</ref>{{#pmid:17817057|PMID17817057}} | | In 1934 progesterone (progestin) was first isolated from the {{corpus luteum}} and its structure reported by four separate groups of researchers.<ref name=Butenandt1934>Butenandt A. Neure Ergebnisse auf dem Gebiet der Sexualhormone. Wien Klin Wochenschr. 1934;47:936.</ref><ref name=Slotta1934>Slotta KH, Ruschig H, Fels E. Ȕber der Hormon aus dem Corpus-luteum. Ber Chem Ges. 1934;67:1270.</ref><ref name=Hartmann1934>Hartmann M, Wettstein A. Ein krystallisiertes Hormon aus Corpus-luteum. Helv Chim Acta. 1934;17:878.</ref>{{#pmid:17817057|PMID17817057}} | ||
This hormone is produced by the granulosa cells of the ovarian follicles at different levels during the {{menstrual cycle}} and at high levels by the {{corpus luteum}} of pregnancy. | |||
Revision as of 11:14, 6 March 2019
Embryology - 16 Jun 2024 Expand to Translate |
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Introduction
The corpus luteum (Latin, corpus = body, luteum = yellow) develops from the remains of Graffian follicle after ovulation. Functions as an endocrine organ (produce progesterone and oestrogens) supporting pregnancy and preventing menstruation (loss of the endometrial lining). Formed during the luteal phase (secretory phase) of the menstrual cycle by proliferation of both follicular granulosa cells (granulosa lutein cells) and thecal cells (theca lutein cells), which together interact to produce progesterone and oestrogens. Ovarian luteal cells have an important role in progesterone (P4) production.
Peak luteal function during the menstrual cycle, determined by maximum luteal area, progesterone concentration and estradiol concentration, is observed about 6 days following ovulation.[1]
If fertilization and pregnancy does not occur, the corpus luteum degenerates to form the corpus albicans.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Corpus Luteum |
History
Regnier de Graaf (1641 – 1673) | Ludwig Fraenkel (1870 - 1951) |
Regnier de Graaf (1641 – 1673) was the first observer in the ovary of a cow as a yellow structure, the yellow colour was caused by accumulation of steroidal hormones. | Ludwig Fraenkel (1870 - 1951) first identified the endocrine function of the corpus luteum.[4] |
Progesterone
In 1934 progesterone (progestin) was first isolated from the corpus luteum and its structure reported by four separate groups of researchers.[5][6][7][8]
This hormone is produced by the granulosa cells of the ovarian follicles at different levels during the menstrual cycle and at high levels by the corpus luteum of pregnancy.
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Progesterone molecular structure |
Histology
Corpus luteum histology | Corpus luteum lutein cells |
Embryo Virtual Slide
Human Ovary and Corpus Luteum |
Ovary | Embryo Slides |
Corpus Luteum Links: anatomy overview | image - histology overview | image - Layers granulosa and theca | image - Layers detail granulosa and theca | image - low power label | image - high power label | image - low power | image - high power | image - corpus albicans | theca and granulosa lutein cells | Granulosa cell | corpus luteum | granulosa lutein cells | theca lutein cells | corpus albicans | ovary | menstrual cycle |
Historic Papers: 1969 corpus luteum ultrastructure 1 | 1969 corpus luteum ultrastructure 2 |
Corpus Albicans
Corpus albicans histology
(corpora albicantia) (Latin, corpus = body, albicans = whitish) The histological structure formed by luteolysis of the corpus luteum in the ovary. If implantation does not occur and the hormone hCG is not released the corpus luteum degenerates and the structure is white, not yellow, because of the absence of steroid hormone synthesis/accumulation.
Corpus Luteum Links: anatomy overview | image - histology overview | image - Layers granulosa and theca | image - Layers detail granulosa and theca | image - low power label | image - high power label | image - low power | image - high power | image - corpus albicans | theca and granulosa lutein cells | Granulosa cell | corpus luteum | granulosa lutein cells | theca lutein cells | corpus albicans | ovary | menstrual cycle |
Historic Papers: 1969 corpus luteum ultrastructure 1 | 1969 corpus luteum ultrastructure 2 |
Animal Models
References
- ↑ Baerwald AR, Adams GP & Pierson RA. (2005). Form and function of the corpus luteum during the human menstrual cycle. Ultrasound Obstet Gynecol , 25, 498-507. PMID: 15846762 DOI.
- ↑ von Versen-Höynck F, Narasimhan P, Selamet Tierney ES, Martinez N, Conrad KP, Baker VL & Winn VD. (2019). Absent or Excessive Corpus Luteum Number Is Associated With Altered Maternal Vascular Health in Early Pregnancy. Hypertension , 73, 680-690. PMID: 30636549 DOI.
- ↑ Xu MQ, Jiang H, Zhang LQ, Sun XL, Luo D, Fu Y, Gao Y, Yuan B & Zhang JB. (2018). MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells. PLoS ONE , 13, e0195562. PMID: 29617446 DOI.
- ↑ Simmer HH. (1971). The first experiments to demonstrate an endocrine function of the corpus luteum. On the occasion of the 100th birthday of Ludwig Fraenkel (1870-1951). Sudhoffs Arch , 55, 392-417. PMID: 4261581
- ↑ Butenandt A. Neure Ergebnisse auf dem Gebiet der Sexualhormone. Wien Klin Wochenschr. 1934;47:936.
- ↑ Slotta KH, Ruschig H, Fels E. Ȕber der Hormon aus dem Corpus-luteum. Ber Chem Ges. 1934;67:1270.
- ↑ Hartmann M, Wettstein A. Ein krystallisiertes Hormon aus Corpus-luteum. Helv Chim Acta. 1934;17:878.
- ↑ Allen WM & Wintersteiner O. (1934). CRYSTALLINE PROGESTIN. Science , 80, 190-1. PMID: 17817057 DOI.
Reviews
Sugino N, Matsuoka A, Taniguchi K & Tamura H. (2008). Angiogenesis in the human corpus luteum. Reprod. Med. Biol. , 7, 91-103. PMID: 29699289 DOI.
Stouffer RL, Bishop CV, Bogan RL, Xu F & Hennebold JD. (2013). Endocrine and local control of the primate corpus luteum. Reprod Biol , 13, 259-71. PMID: 24287034 DOI.
Bachelot A & Binart N. (2005). Corpus luteum development: lessons from genetic models in mice. Curr. Top. Dev. Biol. , 68, 49-84. PMID: 16124996 DOI.
Stouffer RL. (2003). Progesterone as a mediator of gonadotrophin action in the corpus luteum: beyond steroidogenesis. Hum. Reprod. Update , 9, 99-117. PMID: 12751773
Articles
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Search Pubmed: corpus luteum Development
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Cite this page: Hill, M.A. (2024, June 16) Embryology Corpus Luteum Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Corpus_Luteum_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G