Template:Embryonic Liver Timeline Table: Difference between revisions

Latest revision as of 00:52, 1 Haziran 2018

**Embryonic Liver Development Timeline**
Carnegie Stage	Age (days)	CRL (mm)	Biliary system	Vascular	Hepatic parenchyma
14	33	7	Bile duct - primordial duct links primitive intestine and liver parenchyma. Thick-walled tube (95 µm diameter) small lumen (22 µm diameter). Gall bladder - elongated tube further dilated, thick wall (125 µm diameter) and a narrow lumen (43 µm diameter).	Hepatic sinusoids - intra-hepatic vasculature present Three venous tributaries flow into the liver sinusoids - right and left placental vein and a single vitelline vein.	Cords of liver cells fragmented by vascular network of hepatic sinusoids. Between pericardial cavity (top) and mesonephros (bottom). Upper pole of the liver lies close to the septum transversum and early ventricles. Liver occupies the majority of abdominal cavity.
18	46	15	Bile duct (future common bile duct), and a common hepatic duct, in contact with liver parenchyma without penetration. Primordium of accessory bile tract is an elongated and fusiform gall bladder projecting forward and by a short cystic duct that opens into common bile duct. Bile duct empties into second part of duodenum on its posterior side.	Portal system visible - portal vein (100 µm diameter) arises from connection of upper mesenteric vein then at region of hepatic hilum (285 µm) divides into portal branches. Left umbilical vein empties into anterior extremity of the left portal branch. Ductus venosus (80 µm) connects the initial portion of left portal vein to the inferior vena cava. Hepatic venous system 3 branches - left hepatic vein (120 µm in diameter), middle hepatic vein (220 􏰁µm in diameter) and right hepatic vein (160 µm in diameter). Flows into the sub-cardinal vein.	Liver parenchyma has two anatomical lobes (right and left lobe), separated by anteroposterior plane formed by placental vein.
21	53	22.5	Bile duct morphology as earlier stage. Common bile duct empties at the level of the proximal duodenum.	Portal vein arises from joining of splenic vein and superior mesenteric vein. At the level of the hepatic hilum, portal vein divides into two branches, right portal branch (420 µm in diameter) and left portal branch (540 µm in diameter). Right portal branch gives rise to a thin branch to caudate lobe. Ventral branch gives rise to segmental portal veins (VIII and V). Dorsal branch gives rise to the segmental portal veins (VI and VII). Ductus venosus connects initial portion of left portal vein to inferior vena cava, just upstream from hepatic vein afferents. Hepatic venous system as for previous stage.	Hepatic parenchyma a large rounded mass.
23	58	27	Bile duct morphology as earlier stage.	Portal venous system complete. Ductus venosus (40 µm) connects initial portion of portal vein to middle hepatic vein. hepatic venous system has changed very little from the previous stage. Three hepatic veins empty into inferior vena cava.	Liver parenchyma roughly oval shape, 2 symmetrical hepatic lobes. The quadrate and caudate lobes are identifiable. Upper pole of the liver bounded above by diaphragm.
Data from a recent human study^[1] Links: liver \| Carnegie stage 14 \| 18 \| 21 \| 23 \| simple embryonic timeline \| Timeline human development

↑ Lhuaire M, Tonnelet R, Renard Y, Piardi T, Sommacale D, Duparc F, Braun M & Labrousse M. (2015). Developmental anatomy of the liver from computerized three-dimensional reconstructions of four human embryos (from Carnegie stage 14 to 23). Ann. Anat. , 200, 105-13. PMID: 25866917 DOI.

[PMID25866917-1] Lhuaire M, Tonnelet R, Renard Y, Piardi T, Sommacale D, Duparc F, Braun M & Labrousse M. (2015). Developmental anatomy of the liver from computerized three-dimensional reconstructions of four human embryos (from Carnegie stage 14 to 23). Ann. Anat. , 200, 105-13. PMID: 25866917 DOI.

[1]

@@ Line 1: / Line 1: @@
-{| class="wikitable mw-collapsible mw-collapsed"
+{|
-! colspan=6|Embryonic Liver Development Timeline &nbsp;
+|+ colspan=6|'''Embryonic Liver Development Timeline''' &nbsp;
-|-
-| colspan=6|This information is from a recent study<ref name=PMID25866917><pubmed>25866917</pubmed>| [http://www.sciencedirect.com/science/article/pii/S0940960215000382 Ann Anat.]</ref> of the human embryonic liver from week 5 to 8 ({{GA}} 7 to 9; Carnegie stage 14 to 23).
 |-bgcolor="CEDFF2"
-! Carnegie Stage
+! width=80px|Carnegie Stage
-! Age (days)
+! width=80px|Age (days)
-! CRL (mm)
+! width=80px|CRL (mm)
-! Biliary system
+! width=250px|Biliary system
-! Vascular
+! width=250px|Vascular
-! Hepatic parenchyma
+! width=250px|Hepatic parenchyma
 |-
-| [[Carnegie stage 14|'''14''']]
+| {{CS14}}
 | 33
 | 7
 |
-* Primordial bile duct (links primitive intestine and liver parenchyma) visible. Thick-walled tube (95􏰁 µm diameter) with a small lumen (22 µ􏰁m in diameter).
+* Bile duct - primordial duct links primitive intestine and liver parenchyma. Thick-walled tube (95 µm diameter) small lumen (22 µm diameter).
-* Gallbladder - elongated tube further dilated, thick wall (125􏰁  µm in diameter) and a narrow lumen (43􏰁  µm of diameter).
+* Gall bladder - elongated tube further dilated, thick wall (125  µm diameter) and a narrow lumen (43  µm diameter).
 |
-* Intra-hepatic vasculature is represented by the presence of hepatic sinusoids.
+* Hepatic sinusoids - intra-hepatic vasculature present
-* Three venous tributaries flow into the liver sinusoids: a large right umbilical vein, a large left placental vein and a single vitelline vein.
+* Three venous tributaries flow into the liver sinusoids - right and left placental vein and a single vitelline vein.
 |
-* Cords of liver cells are fragmented by vascular network of the hepatic sinusoids.
+* Cords of liver cells fragmented by vascular network of hepatic sinusoids.
-* Located between the pericardial cavity at the top and the mesonephros at the bottom.
+* Between pericardial cavity (top) and mesonephros (bottom).
 * Upper pole of the liver lies close to the septum transversum and early ventricles.
 * Liver occupies the majority of abdominal cavity.
 |-bgcolor="F5FAFF"
-| [[Carnegie stage 18|'''18''']]
+| {{CS18}}
 | 46
 | 15
 |
-* Bile duct (future common bile duct), and a common hepatic duct, which is in contact with the liver parenchyma without penetration.
+* Bile duct (future common bile duct), and a common hepatic duct, in contact with liver parenchyma without penetration.
-* Primordium of accessory bile tract is an elongated and fusiform gall bladder projecting forward and by a short cystic duct that opens into the common bile duct.
+* Primordium of accessory bile tract is an elongated and fusiform gall bladder projecting forward and by a short cystic duct that opens into common bile duct.
-* The bile duct empties into the second part of duodenum on its posterior side.
+* Bile duct empties into second part of duodenum on its posterior side.
 |
-* Portal system visible - portal vein (100 µ􏰁m diameter) arises from the connection of the upper mesenteric vein then at region of the hepatic hilum (285􏰁 µm) divides into portal branches.
+* Portal system visible - portal vein (100 µm diameter) arises from connection of upper mesenteric vein then at region of hepatic hilum (285 µm) divides into portal branches.
-* Left umbilical vein empties into the anterior extremity of the left portal branch.
+* Left umbilical vein empties into anterior extremity of the left portal branch.
 * Ductus venosus (80  µm) connects the initial portion of left portal vein to the inferior vena cava.
-* Hepatic venous system 3 branches - left hepatic vein (120􏰁 µm in diameter),  middle hepatic vein (220 􏰁µm in diameter) and right hepatic vein (160􏰁 µm in diameter). Flows into the sub-cardinal vein.
+* Hepatic venous system 3 branches - left hepatic vein (120 µm in diameter),  middle hepatic vein (220 􏰁µm in diameter) and right hepatic vein (160 µm in diameter). Flows into the sub-cardinal vein.
 |
-* Liver parenchyma has two anatomical lobes, a right lobe and a left lobe, separated by the anteroposterior plane formed by the placental vein.
+* Liver parenchyma has two anatomical lobes (right and left lobe), separated by anteroposterior plane formed by placental vein.
 |-
-| [[Carnegie stage 21|'''21''']]
+| {{CS21}}
 | 53
 | 22.5
 | Bile duct morphology as earlier stage. Common bile duct empties at the level of the proximal duodenum.
 |
-* Portal vein arises from the joining of the splenic vein and the superior mesenteric vein. At the level of the hepatic hilum, portal vein divides into two branches, right portal branch (420  µm in diameter) and left portal branch (540 􏰁m in diameter). Right portal branch gives rise to a thin branch to the caudate lobe. Ventral branch gives rise to segmental portal veins (VIII and V). Dorsal branch gives rise to the segmental portal veins (VI and VII).
+* Portal vein arises from joining of splenic vein and superior mesenteric vein. At the level of the hepatic hilum, portal vein divides into two branches, right portal branch (420 µm in diameter) and left portal branch (540 µm in diameter). Right portal branch gives rise to a thin branch to caudate lobe. Ventral branch gives rise to segmental portal veins (VIII and V). Dorsal branch gives rise to the segmental portal veins (VI and VII).
-* Ductus venosus connects the initial portion of the left portal vein to the inferior vena cava just upstream from the hepatic vein afferents.
+* Ductus venosus connects initial portion of left portal vein to inferior vena cava, just upstream from  hepatic vein afferents.
 * Hepatic venous system as for previous stage.
-| Hepatic parenchyma looks like a large rounded mass.
+| Hepatic parenchyma a large rounded mass.
 |-bgcolor="F5FAFF"
-| [[Carnegie stage 23|'''23''']]
+| {{CS23}}
 | 58
 | 27
@@ Line 57: / Line 55: @@
 |
 * Portal venous system complete.
-* Ductus venosus (40 m) connects the initial portion of the portal vein to the middle hepatic vein.
+* Ductus venosus (40 µm) connects initial portion of portal vein to middle hepatic vein.
-* hepatic venous system has changed very little from the previous stage. the three hepatic veins empty into the inferior vena cava.
+* hepatic venous system has changed very little from the previous stage. Three hepatic veins empty into  inferior vena cava.
 |
-* Liver parenchyma has a roughly oval shape. Two symmetrical hepatic lobes are identifiable. The quadrate and caudate lobes are identifiable.
+* Liver parenchyma roughly oval shape, 2 symmetrical hepatic lobes. The quadrate and caudate lobes are identifiable.
-* Upper pole of the liver is always bounded above by the diaphragm.
+* Upper pole of the liver bounded above by diaphragm.
 |-
-| colspan=6|'''Links:''' [[Gastrointestinal Tract - Liver Development|Liver Development]] | [[Carnegie stage 14]] | [[Carnegie stage 18]] | [[Carnegie stage 21]] | [[Carnegie stage 23]] | [[Timeline human development]]
+| colspan=6|Data from a recent human study{{#pmid:25866917|PMID25866917}}<br>
+'''Links:''' {{liver}} | Carnegie stage {{CS14}} | {{CS18}} | {{CS21}} | {{CS23}} | [[:Template:Liver stages simple table01|simple embryonic timeline]] | [[Timeline human development]]
 |}<noinclude>[[Category:Liver]][[Category:Human Embryo]][[Category:Timeline]][[Category:Template]][[Category:Table]]</noinclude>