File:Hypothalamus gene interaction model.jpg: Difference between revisions

Hypothalamus Development Gene Interaction Model

Summary of potential regulatory interaction model of gene regulation for neurogenesis in the hypothalamus revealed by in silico analysis and literature.

A model of interaction between the negative regulators HES5 and HEY1 and the positive regulators ASCL1 and NHLH1 based on the literature and present data.

• Activations - identified with a red arrow
• Repressions - identified with a green barred line.
• Purple arrow - activation of NOTCH receptor by its ligand DLL1.

(Bertrand, 2002; Gohkle, 2008, Castro, 2011, de la Pompa 1997, and paper data).

Links: Hypothalamus | Notch

Reference

Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V & Dupé V. (2013). Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev , 8, 25. PMID: 24360028 DOI.

Copyright

© 2013 Ratié et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Ratié et al. Neural Development 2013 8:25 doi:10.1186/1749-8104-8-25

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