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| colspan=2|<span style="font-size:150%">'''Oocyte/Spermatozoa fate decision by Primordial Germ Cells'''</span> | | colspan=2|<span style="font-size:150%">'''News - Oocyte/Spermatozoa fate decision by Primordial Germ Cells'''</span> | ||
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| valign=top|[[File:Medaka.jpg|alt=Medaka|link=Medaka Development|250px|left]] | | valign=top|[[File:Medaka.jpg|alt=Medaka|link=Medaka Development|250px|left]] | ||
Revision as of 09:19, 16 June 2015
| News - Oocyte/Spermatozoa fate decision by Primordial Germ Cells | |
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Medaka Sex determination is an essential step in the commitment of a germ cell to a spermatozoa or oocyte. The intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. "foxl3 (Forkhead Transcription Factor l3, an ancient duplicated copy of foxl2) is expressed in germ cells but not somatic cells in the gonad, and has been identified as involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment." (More? PMID 26067255 | Medaka Development | Oocyte Development | Spermatozoa Development) Older News Articles Rubella eliminated in the Americas | Three-person embryos | 2014 Nobel Prize in Medicine - Neural Development | Hippocampus Development | WHO - Trends in Maternal Mortality 1990 to 2013 - Statistics - Maternal Mortality | WHO Report Page | WHO polio - Polio Virus | Trisomy 21 - Genome-wide Effects |
