File:Hypothalamus gene interaction model.jpg: Difference between revisions

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Hypothalamus Development Gene Interaction Model

Summary of potential regulatory interaction model of gene regulation for neurogenesis in the hypothalamus revealed by in silico analysis and literature.

A model of interaction between the negative regulators HES5 and HEY1 and the positive regulators ASCL1 and NHLH1 based on the literature and present data.

Activations - identified with a red arrow
Repressions - identified with a green barred line.
Purple arrow - activation of NOTCH receptor by its ligand DLL1.

(Bertrand, 2002; Gohkle, 2008, Castro, 2011, de la Pompa 1997, and paper data).

Links: Hypothalamus | Notch

Reference

<pubmed>24360028</pubmed>| Neural Dev.

Copyright

© 2013 Ratié et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Ratié et al. Neural Development 2013 8:25 doi:10.1186/1749-8104-8-25

1749-8104-8-25-5.jpg

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Author	Vincoy, Jhunalyn
Unique ID of original document	uuid:5D20892493BFDB11914A8590D31508C8
Software used	Adobe Illustrator CS5
Short title	Print
IIM version	2

@@ Line 3: / Line 3: @@
 Summary of potential regulatory interaction model of gene regulation for neurogenesis in the hypothalamus revealed by in silico analysis and literature.
-A model of interaction between the negative regulators HES5 and HEY1 and the positive regulators ASCL1 and NHLH1 based on the literature and present data. Activations are identified with a red arrow and repressions are identified with a green barred line. The purple arrow refers to the activation of NOTCH receptor by its ligand DLL1. (Bertrand, 2002; Gohkle, 2008, Castro, 2011, de la Pompa 1997, and present data) [13,29,34,50].
+A model of interaction between the negative regulators HES5 and HEY1 and the positive regulators ASCL1 and NHLH1 based on the literature and present data.
+* Activations - identified with a red arrow
+* Repressions - identified with a green barred line.
+* Purple arrow - activation of NOTCH receptor by its ligand DLL1.
+(Bertrand, 2002; Gohkle, 2008, Castro, 2011, de la Pompa 1997, and paper data).