Mifepristone: Difference between revisions
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==Function== | ==Function== | ||
[[File:Model mifepristone bound to progesterone receptor.jpg|thumb|300px|Model mifepristone bound to progesterone receptor.<ref name=PMID19372222><pubmed>19372222</pubmed></ref>]] | |||
A progesterone receptor antagonist. | A progesterone receptor antagonist. | ||
* Progesterone normally binds to the progesterone receptor and generates a receptor conformational change allowing it to then bind to DNA and act as a transcription factor for genes. | * Progesterone normally binds to the progesterone receptor and generates a receptor conformational change allowing it to then bind to DNA and act as a transcription factor for genes. |
Revision as of 12:58, 5 May 2013
Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose. |
Introduction
(RU 486) A progesterone receptor antagonist similar in structure to the natural hormone progesterone, which is used medically as a birth control drug. Progesterone is a steroidal hormone of the progestogens class, which has many roles in the female. Functions include regulation of the menstrual cycle, uterine changes, maintaining pregnancy and effects on systems throughout the body. Biological sources include: adrenal glands, gonads (corpus luteum), brain, and placenta. Male progesterone has a suggested role in neural development. Progesterone is also used clinically as a part of hormone replacement therapy (HRT) in women. The human progesterone receptor has two isoforms (PRA and PRB). Commercial drug names include Mifegyne and Mifeprex.
- Links: Menstrual Cycle
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Mifepristone <pubmed limit=5>Mifepristone</pubmed> |
Function
A progesterone receptor antagonist.
- Progesterone normally binds to the progesterone receptor and generates a receptor conformational change allowing it to then bind to DNA and act as a transcription factor for genes.
- Mifepristone binds the same progesterone receptor with 10-fold higher affinity. It binds to the C-terminal region of the hormone-binding domain and then does not act as a transcription factor.
Also binds to the glucocorticoid receptor (GR) and weakly to the androgen receptor.
Ulipristal
A new chemical and pharmacological analog of mifepristone, acting as a selective progesterone receptor modulator. Currently identified as a second generation emergency contraceptive.
- trade name - ella® (Laboratoire HRA Pharma, Paris, France)
Images
References
Reviews
<pubmed>22071804</pubmed> <pubmed>20933118</pubmed> <pubmed>20102310</pubmed> <pubmed>20004266</pubmed> <pubmed>15192056</pubmed>
Articles
Journals
Search Pubmed
Search Pubmed: Mifepristone | 486 RU 486
Glossary Links
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Cite this page: Hill, M.A. (2024, June 26) Embryology Mifepristone. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mifepristone
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G