|Embryology - 1 Jun 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
|Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.|
Progesterone is a steroidal hormone of the progestogens class, which has many roles in the female. Functions include regulation of the menstrual cycle, uterine changes, maintaining pregnancy and effects on systems throughout the body. Biological sources include: adrenal glands, gonads (corpus luteum), brain, and placenta.
Male progesterone has a suggested role in neural development. Progesterone is also used clinically as a part of hormone replacement therapy (HRT) in women. The human progesterone receptor has two isoforms (PRA and PRB).
Commercial drug names include Mifegyne and Mifeprex.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
Search term: Mifepristone
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
A progesterone receptor antagonist.
- Progesterone normally binds to the progesterone receptor and generates a receptor conformational change allowing it to then bind to DNA and act as a transcription factor for genes.
- Mifepristone binds the same progesterone receptor with 10-fold higher affinity. It binds to the C-terminal region of the hormone-binding domain and then does not act as a transcription factor.
Also binds to the glucocorticoid receptor (GR) and weakly to the androgen receptor.
A new chemical and pharmacological analog of mifepristone, acting as a selective progesterone receptor modulator. Currently identified as a second generation emergency contraceptive.
- trade name - ella® (Laboratoire HRA Pharma, Paris, France)
The drug methotrexate (MTX, amethopterin) is a folic acid antagonist and is used clinically as a chemotherapy agent (cancer), immune system suppressant (autoimmune diseases), treating treating rheumatoid arthritis and for medical abortions with ectopic pregnancy.
- Links: folic acid | Abnormal_Development_-_Ectopic_Implantation#Methotrexate Ectopic Pregnancy | ectopic implantation | Medline Plus | PubChem
- de Costa CM, Black KI & Russell DB. (2019). Medical abortion: it is time to lift restrictions. Med. J. Aust. , 210, 248-249.e1. PMID: 30861138 DOI.
- Llorens-Martín M & Trejo JL. (2011). Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice. PLoS ONE , 6, e28376. PMID: 22140582 DOI.
- Ngoc NT, Blum J, Raghavan S, Nga NT, Dabash R, Diop A & Winikoff B. (2011). Comparing two early medical abortion regimens: mifepristone+misoprostol vs. misoprostol alone. Contraception , 83, 410-7. PMID: 21477682 DOI.
- Raaijmakers HC, Versteegh JE & Uitdehaag JC. (2009). The X-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation. J. Biol. Chem. , 284, 19572-9. PMID: 19372222 DOI.
- Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA & Suarez-Almazor ME. (2014). Methotrexate for treating rheumatoid arthritis. Cochrane Database Syst Rev , , CD000957. PMID: 24916606 DOI.
- Marret H, Fauconnier A, Dubernard G, Misme H, Lagarce L, Lesavre M, Fernandez H, Mimoun C, Tourette C, Curinier S, Rabishong B & Agostini A. (2016). Overview and guidelines of off-label use of methotrexate in ectopic pregnancy: report by CNGOF. Eur. J. Obstet. Gynecol. Reprod. Biol. , 205, 105-9. PMID: 27572300 DOI.
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Cite this page: Hill, M.A. (2020, June 1) Embryology Mifepristone. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Mifepristone
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G