Advanced - Cardiac Septation: Difference between revisions
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Two endocardial cushions form on the dorsal and ventral surfaces of the AV canal. Following expansion of the cardiac jelly, epithelial to mesenchymal transformation (EMT) of the endocardial cells in the canal occurs forming the cushions. Synergistic signalling between BMP and TGFβ facilitates EMT. The cushions grow as they are invaded by mesenchymal cells from the endocardium during the fifth week, eventually fusing to create the right and left AV canals, hence partially separating the primitive atrium and ventricle. | Two endocardial cushions form on the dorsal and ventral surfaces of the AV canal. Following expansion of the cardiac jelly, epithelial to mesenchymal transformation (EMT) of the endocardial cells in the canal occurs forming the cushions. Synergistic signalling between BMP and TGFβ facilitates EMT. The cushions grow as they are invaded by mesenchymal cells from the endocardium during the fifth week, eventually fusing to create the right and left AV canals, hence partially separating the primitive atrium and ventricle. | ||
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<qt>file=Heart septation 001.mov|width=720px|height=565px|controller=true|autoplay=false</qt> | <qt>file=Heart septation 001.mov|width=720px|height=565px|controller=true|autoplay=false</qt> | ||
Revision as of 20:21, 26 February 2013
| Begin Advanced | Heart Fields | Heart Tubes | Cardiac Looping | Cardiac Septation | Outflow Tract | Valve Development | Cardiac Conduction | Cardiac Abnormalities | Molecular Development |
| Cardiac Embryology | Begin Basic | Begin Intermediate | Begin Advanced |
All of the partitioning of the primitive heart occurs between the middle of the fourth week and the end of the fifth week. Division of the atrioventricular canal is described below while septation of the atria and ventricles is described here.
Division of the AV Canal
Two endocardial cushions form on the dorsal and ventral surfaces of the AV canal. Following expansion of the cardiac jelly, epithelial to mesenchymal transformation (EMT) of the endocardial cells in the canal occurs forming the cushions. Synergistic signalling between BMP and TGFβ facilitates EMT. The cushions grow as they are invaded by mesenchymal cells from the endocardium during the fifth week, eventually fusing to create the right and left AV canals, hence partially separating the primitive atrium and ventricle.
Embryology - 15 Nov 2026    Expand to Translate
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<qt>file=Heart septation 001.mov|width=720px|height=565px|controller=true|autoplay=false</qt>
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| Go to this section in the intermediate level |
