Template:Blastocyst Hippo table

From Embryology
Mouse Blastocyst (32 cell stage) Fate
Inner cells Outer cells
Angiomotin (Amot) phosphorylation at adherens junctions Amot sequestered by cell polarization from basolateral adherens junctions
Hippo active Hippo inactive
Notch inactive Notch active
Cdx2 not expressed Cdx2 expressed
ICM - inner cell mass fate TE - trophectoderm fate

Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development.

  1. Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
  2. Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.