Talk:Neural System - Glial Development
TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain
Front Cell Neurosci. 2018 Nov 28;12:448. doi: 10.3389/fncel.2018.00448. eCollection 2018.
Weise SC1,2,3, Villarreal A1, Heidrich S1, Dehghanian F1,4, Schachtrup C1, Nestel S3, Schwarz J5,6, Thedieck K7,8, Vogel T1. Author information Abstract Heterogeneous astrocyte populations are defined by diversity in cellular environment, progenitor identity or function. Yet, little is known about the extent of the heterogeneity and how this diversity is acquired during development. To investigate the impact of TGF (transforming growth factor) β-signaling on astrocyte development in the telencephalon we deleted the TGFBR2 (transforming growth factor beta receptor 2) in early neural progenitor cells in mice using a FOXG1 (forkhead box G1)-driven CRE-recombinase. We used quantitative proteomics to characterize TGFBR2-deficient cells derived from the mouse telencephalon and identified differential protein expression of the astrocyte proteins GFAP (glial fibrillary acidic protein) and MFGE8 (milk fat globule-EGF factor 8). Biochemical and histological investigations revealed distinct populations of astrocytes in the dorsal and ventral telencephalon marked by GFAP or MFGE8 protein expression. The two subtypes differed in their response to TGFβ-signaling. Impaired TGFβ-signaling affected numbers of GFAP astrocytes in the ventral telencephalon. In contrast, TGFβ reduced MFGE8-expression in astrocytes deriving from both regions. Additionally, lineage tracing revealed that both GFAP and MFGE8 astrocyte subtypes derived partly from FOXG1-expressing neural precursor cells.
KEYWORDS: SILAC; Tgfbr2 knockout; astrocyte-diversity; lineage-tracing; neural differentiation PMID: 30555301 PMCID: PMC6282056 DOI: 10.3389/fncel.2018.00448
Microglia and early brain development: An intimate journey
Science. 2018 Oct 12;362(6411):185-189. doi: 10.1126/science.aat0474.
Thion MS1, Ginhoux F2,3, Garel S1. Author information Abstract Cross-talk between the nervous and immune systems has been well described in the context of adult physiology and disease. Recent advances in our understanding of immune cell ontogeny have revealed a notable interplay between neurons and microglia during the prenatal and postnatal emergence of functional circuits. This Review focuses on the brain, where the early symbiotic relationship between microglia and neuronal cells critically regulates wiring, contributes to sex-specific differences in neural circuits, and relays crucial information from the periphery, including signals derived from the microbiota. These observations underscore the importance of studying neurodevelopment as part of a broader framework that considers nervous system interactions with microglia in a whole-body context.
Copyright © 2018, American Association for the Advancement of Science.
PMID: 30309946 DOI: 10.1126/science.aat0474
Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation
Neurochem Int. 2018 Oct;119:178-183. doi: 10.1016/j.neuint.2017.11.003. Epub 2017 Nov 6.
Hashimoto H1, Jiang W1, Yoshimura T1, Moon KH2, Bok J3, Ikenaka K4.
In the mouse neural tube, sonic hedgehog (Shh) secreted from the floor plate (FP) and the notochord (NC) regulates ventral patterning of the neural tube, and later is essential for the generation of oligodendrocyte precursor cells (OPCs). During early development, the NC is adjacent to the neural tube and induces ventral domains in it, including the FP. In the later stage of development, during gliogenesis in the spinal cord, the pMN domain receives strong Shh signaling input. While this is considered to be essential for the generation of OPCs, the actual role of this strong input in OPC generation remains unclear. Here we studied OPC generation in bromi mutant mice which show abnormal ciliary structure. Shh signaling occurs within cilia and has been reported to be weak in bromi mutants. At E11.5, accumulation of Patched1 mRNA, a Shh signaling reporter, is observed in the pMN domain of wild type but not bromi mutants, whereas expression of Gli1 mRNA, another Shh reporter, disappeared. Thus, Shh signaling input to the pMN domain at E12.5 was reduced in bromi mutant mice. In these mutants, induction of the FP structure was delayed and its size was reduced compared to wild type mice. Furthermore, while the p3 and pMN domains were induced, the length of the Nkx2.2-positive region and the number of Olig2-positive cells decreased. The number of OPCs was also significantly decreased in the E12.5 and E14.5 bromi mutant spinal cord. In contrast, motor neuron (MN) production, detected by HB9 expression, significantly increased. It is likely that the transition from MN production to OPC generation in the pMN domain is impaired in bromi mutant mice. These results suggest that strong Shh input to the pMN domain is not required for OPC generation but is essential for producing a sufficient number of OPCs. KEYWORDS: Bromi; Embryonic spinal cord; Floor plate; Oligodendrocyte; Sonic hedgehog signaling PMID: 29122585 DOI: 10.1016/j.neuint.2017.11.003
Radial glial cells: key organisers in CNS development
Int J Biochem Cell Biol. 2014 Jan;46:76-9. doi: 10.1016/j.biocel.2013.11.013. Epub 2013 Nov 21.
Barry DS1, Pakan JM2, McDermott KW2.
Abstract Radial glia are elongated bipolar cells present in the CNS during development. Our understanding of the unique roles these cells play has significantly expanded in the last decade. Historically, radial glial cells were primarily thought to provide an architectural framework for neuronal migration. Recent research reveals that radial glia play a more dynamic and integrated role in the development of the brain and spinal cord. They represent a major progenitor pool during early development and can give rise to a small population of multipotent cells in neurogenic niches of the adult CNS. Radial glial cells are a heterogeneous population, with divergent and often poorly understood roles across different brain and spinal cord regions during development; this heterogeneity extends to specialised adult subtypes, such as tanycytes, Müller glial cells and Bergman glial cells which possess morphological similarities to radial glial but play distinct functional roles in the CNS. Copyright © 2013 Elsevier Ltd. All rights reserved. KEYWORDS: Glioma; Neurodevelopment; Neuronal migration; Radial glia PMID 24269781
Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
Development. 2014 Jan;141(1):39-50. doi: 10.1242/dev.098418. Epub 2013 Nov 20.
Hoffmann SA1, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S.
Neural precursor cells of the ventricular zone give rise to all neurons and glia of the central nervous system and rely for maintenance of their precursor characteristics on the closely related SoxB1 transcription factors Sox1, Sox2 and Sox3. We show in mouse spinal cord that, whereas SoxB1 proteins are usually downregulated upon neuronal specification, they continue to be expressed in glial precursors. In the oligodendrocyte lineage, Sox2 and Sox3 remain present into the early phases of terminal differentiation. Surprisingly, their deletion does not alter precursor characteristics but interferes with proper differentiation. Although a direct influence on myelin gene expression may be part of their function, we provide evidence for another mode of action. SoxB1 proteins promote oligodendrocyte differentiation in part by negatively controlling miR145 and thereby preventing this microRNA from inhibiting several pro-differentiation factors. This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions. KEYWORDS: Glia; High mobility group; MicroRNA; Myelin; Transcriptional control
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage
J Cell Biol. 2010 May 17;189(4):701-12. Epub 2010 May 10.
Finzsch M, Schreiner S, Kichko T, Reeh P, Tamm ER, Bösl MR, Meijer D, Wegner M.
Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Abstract Mutations in the transcription factor SOX10 cause neurocristopathies, including Waardenburg-Hirschsprung syndrome and peripheral neuropathies in humans. This is partly attributed to a requirement for Sox10 in early neural crest for survival, maintenance of pluripotency, and specification to several cell lineages, including peripheral glia. As a consequence, peripheral glia are absent in Sox10-deficient mice. Intriguingly, Sox10 continues to be expressed in these cells after specification. To analyze glial functions after specification, we specifically deleted Sox10 in immature Schwann cells by conditional mutagenesis. Mutant mice died from peripheral neuropathy before the seventh postnatal week. Nerve alterations included a thinned perineurial sheath, increased lipid and collagen deposition, and a dramatically altered cellular composition. Nerve conduction was also grossly aberrant, and neither myelinating nor nonmyelinating Schwann cells formed. Instead, axons of different sizes remained unsorted in large bundles. Schwann cells failed to develop beyond the immature stage and were unable to maintain identity. Thus, our study identifies a novel cause for peripheral neuropathies in patients with SOX10 mutations.
Growth of the human corpus callosum: modular and laminar morphogenetic zones
Front Neuroanat. 2009;3:6. Epub 2009 Jun 9.
Jovanov-Milosević N, Culjat M, Kostović I.
Croatian Institute for Brain Research, School of Medicine, University of Zagreb Zagreb, Croatia. Abstract The purpose of this focused review is to present and discuss recent data on the changing organization of cerebral midline structures that support the growth and development of the largest commissure in humans, the corpus callosum. We will put an emphasis on the callosal growth during the period between 20 and 45 postconceptual weeks (PCW) and focus on the advantages of a correlated histological/magnetic resonance imaging (MRI) approach. The midline structures that mediate development of the corpus callosum in rodents, also mediate its early growth in humans. However, later phases of callosal growth in humans show additional medial transient structures: grooves made up of callosal septa and the subcallosal zone. These modular (septa) and laminar (subcallosal zone) structures enable the growth of axons along the ventral callosal tier after 18 PCW, during the rapid increase in size of the callosal midsagittal cross-section area. Glial fibrillary acidic protein positive cells, neurons, guidance molecule semaphorin3A in cells and extracellular matrix (ECM), and chondroitin sulfate proteoglycan in the ECM have been identified along the ventral callosal tier in the protruding septa and subcallosal zone. Postmortem MRI at 3 T can demonstrate transient structures based on higher water content in ECM, and give us the possibility to follow the growth of the corpus callosum in vivo, due to the characteristic MR signal. Knowledge about structural properties of midline morphogenetic structures may facilitate analysis of the development of interhemispheric connections in the normal and abnormal fetal human brain.
Cell migration in the normal and pathological postnatal mammalian brain
Integrin-mediated axoglial interactions initiate myelination in the central nervous system
J Cell Biol. 2009 May 18;185(4):699-712.
Câmara J, Wang Z, Nunes-Fonseca C, Friedman HC, Grove M, Sherman DL, Komiyama NH, Grant SG, Brophy PJ, Peterson A, ffrench-Constant C.
Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK. Abstract
All but the smallest-diameter axons in the central nervous system are myelinated, but the signals that initiate myelination are unknown. Our prior work has shown that integrin signaling forms part of the cell-cell interactions that ensure only those oligodendrocytes contacting axons survive. Here, therefore, we have asked whether integrins regulate the interactions that lead to myelination. Using homologous recombination to insert a single-copy transgene into the hypoxanthine phosphoribosyl transferase (hprt) locus, we find that mice expressing a dominant-negative beta1 integrin in myelinating oligodendrocytes require a larger axon diameter to initiate timely myelination. Mice with a conditional deletion of focal adhesion kinase (a signaling molecule activated by integrins) exhibit a similar phenotype. Conversely, transgenic mice expressing dominant-negative beta3 integrin in oligodendrocytes display no myelination abnormalities. We conclude that beta1 integrin plays a key role in the axoglial interactions that sense axon size and initiate myelination, such that loss of integrin signaling leads to a delay in myelination of small-diameter axons.
The contributions of Santiago Ramón y Cajal to cancer research — 100 years on
J Anat. 2005 Sep;207(3):241-50. Role of radial glia in cytogenesis, patterning and boundary formation in the developing spinal cord. McDermott KW1, Barry DS, McMahon SS. Author information Abstract Radial glial fibres provide a transient scaffold and impose constraints in the developing central nervous system (CNS) that facilitate cell migration and axon growth. Recent reports have raised doubts about the distinction between radial glia and precursor cells by demonstrating that radial glia are themselves neuronal progenitor cells in the developing cortex, indicating a dual role for radial glia in both neurogenesis and migration guidance. Radial glia shift toward exclusive generation of astrocytes after neurogenesis has ceased. Radial progenitor cell differentiation and lineage relationships in CNS development are complex processes depending on genetic programming, cell-cell interaction and microenvironmental factors. In the spinal cord, radial cells that arise directly from the neuroepithelium have been identified. At least in the spinal cord, these radial cells appear to be the precursors to radial glia. It remains unknown whether radial glial cells or their precursors, the radial cells, or both can give rise to neurons in the spinal cord. Radial glial cells are also important in regulating the axon out-growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. PMID 16185248
Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development
Eur J Neurosci. 2008 Oct;28(8):1449-56.
Bayatti N, Sarma S, Shaw C, Eyre JA, Vouyiouklis DA, Lindsay S, Clowry GJ.
Institute of Neuroscience, Newcastle University, Newcastle-upon-Tyne, UK. Abstract The transcription factors Emx2 and Pax6 are expressed in the proliferating zones of the developing rodent neocortex, and gradients of expression interact in specifying caudal and rostral identities. Pax6 is also involved in corticoneurogenesis, being expressed by radial glial progenitors that give rise to cells that also sequentially express Tbr2, NeuroD and Tbr1, genes temporally downstream of Pax6. In this study, using in situ hybridization, we analysed the expression of EMX2, PAX6, TBR2, NEUROD and TBR1 mRNA in the developing human cortex between 8 and 12 postconceptional weeks (PCW). EMX2 mRNA was expressed in the ventricular (VZ) and subventricular zones (SVZ), but also in the cortical plate, unlike in the rodent. However, gradients of expression were similar to that of the rodent at all ages studied. PAX6 mRNA expression was limited to the VZ and SVZ. At 8 PCW, PAX6 was highly expressed rostrally but less so caudally, as has been seen in the rodent, however this gradient disappeared early in corticogenesis, by 9 PCW. There was less restricted compartment-specific expression of TBR2, NEUROD and TBR1 mRNA than in the rodent, where the gradients of expression were similar to that of PAX6 prior to 9 PCW. The gradient disappeared for TBR2 by 10 PCW, and for NEUROD and TBR1 by 12 PCW. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents.
Role of radial glia in cytogenesis, patterning and boundary formation in the developing spinal cord
J Anat. 2005 Sep;207(3):241-50.
McDermott KW1, Barry DS, McMahon SS.
Radial glial fibres provide a transient scaffold and impose constraints in the developing central nervous system (CNS) that facilitate cell migration and axon growth. Recent reports have raised doubts about the distinction between radial glia and precursor cells by demonstrating that radial glia are themselves neuronal progenitor cells in the developing cortex, indicating a dual role for radial glia in both neurogenesis and migration guidance. Radial glia shift toward exclusive generation of astrocytes after neurogenesis has ceased. Radial progenitor cell differentiation and lineage relationships in CNS development are complex processes depending on genetic programming, cell-cell interaction and microenvironmental factors. In the spinal cord, radial cells that arise directly from the neuroepithelium have been identified. At least in the spinal cord, these radial cells appear to be the precursors to radial glia. It remains unknown whether radial glial cells or their precursors, the radial cells, or both can give rise to neurons in the spinal cord. Radial glial cells are also important in regulating the axon out-growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. PMID: 16185248
Radial glia: multi-purpose cells for vertebrate brain development
Trends Neurosci. 2002 May;25(5):235-8.
Campbell K1, Götz M.
Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from the ventricular zone to the mantle regions. Recent data indicate further important roles for these cells as ubiquitous precursors that generate neurons and glia, and as key elements in patterning and region-specific differentiation of the CNS. Thus, from being regarded mainly as support cells, radial glia have emerged as multi-purpose cells involved in most aspects of brain development. PMID 11972958
Patterns of glial development in the human foetal spinal cord during the late first and second trimester
J Neurocytol. 1994 Jun;23(6):343-53.
Weidenheim KM, Epshteyn I, Rashbaum WK, Lyman WD.
Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, New York. Abstract
Although the presence of radial glia, astrocytes, oligodendrocytes and microglia has been reported in the human foetal spinal cord by ten gestational weeks, neuroanatomic studies employing molecular probes that describe the interrelated development of these cells from the late first trimester through the late second trimester are few. In this study, immunocytochemical methods using antibodies to vimentin and glial fibrillary acidic protein were used to identify radial glial and/or astrocytes. An antibody to myelin basic protein was used for oligodendrocytes and myelin; and, an antibody to phosphorylated high and medium molecular weight neurofilaments identified axons. Lectin histochemistry using Ricinus communis agglutinin-I was employed to identify microglia. Vibratome sections from 35 human foetal spinal cord ranging in age from 9-20 gestation weeks were studied. By 12 gestational weeks, vimentin-positive radial glia were present at all three levels of the spinal cord. Their processes were easily identified in the dorsal two-thirds of cord sections, and reaction product for vimentin was more intense at cervical and thoracic levels than lumbosacral sections. By 15 gestational weeks, vimentin-positive processes were radially arranged in the white matter. At this time, glial fibrillary acidic protein-positive astrocytes were more obvious in both the anterior and anterolateral funiculi than in the dorsal funiculus, and the same rostral to caudal gradient was seen for glial fibrillary acidic protein as it was for vimentin. Myelin basic protein expression followed similar temporal and spatial patterns. Ricinus communis agglutinin-I labelling revealed more microglia in the white matter than in grey matter throughout the spinal cord from 10-20 gestational weeks. By 20 gestational weeks, the gradients of glial fibrillary acidic protein and vimentin expression were more difficult to discern. White matter contained more microglia than grey matter. These results suggest that astrocytes as well as oligodendrocytes follow anterior-to-posterior and rostral-to-caudal developmental patterns in the human foetus during middle trimester development.
12 gestational weeks - vimentin-positive radial glia 15 gestational weeks - vimentin-positive processes were radially arranged in the white matter. 20 gestational weeks - gradients of glial fibrillary acidic protein and vimentin expression were more difficult to discern.
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
Brain Res Dev Brain Res. 1999 Nov 18;117(2):145-52.
Alliot F1, Godin I, Pessac B.
Microglia, the resident CNS macrophages, represent about 10% of the adult brain cell population. Although described a long time ago, their origin and developmental lineage is still debated. While del Rio-Hortega suggested that microglia originate from meningeal macrophages penetrating the brain during embryonic development, many authors claim that brain parenchymal microglia derive from circulating blood monocytes originating from bone marrow. We have previously reported that the late embryonic and adult mouse brain parenchyma contains potential microglial progenitors [F. Alliot, E. Lecain, B. Grima, B. Pessac, Microglial progenitors with a high proliferative capacity in the embryonic and the adult mouse brain, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 1541-1545]. We now report that they can be detected in the brain rudiment from embryonic day 8, after their appearance in the yolk sac and that their number increases until late gestation. We also show that microglia appear during embryonic development and that their number increases steadily during the first two postnatal weeks, when about 95% of microglia are born. Finally, the main finding of this study is that microglia is the result of in situ proliferation, as shown by the high proportion of parenchymal microglial cells that express PCNA, a marker of cell multiplication, in embryonic and postnatal brain. Taken together, our data support the hypothesis that terminally differentiated brain parenchymal microglia are derived from cells originating from the yolk sac whose progeny actively proliferates in situ during development.
1: Giddabasappa A, Hamilton WR, Chaney S, Xiao W, Johnson JE, Mukherjee S, Fox DA. Low-Level Gestational Lead Exposure Increases Retinal Progenitor Cell Proliferation and Rod Photoreceptor and Bipolar Cell Neurogenesis in Mice. Environ Health Perspect. 2010 Sep 14. [Epub ahead of print] PubMed PMID: 20840909.
2: Saura CA. Presenilin/gamma-Secretase and Inflammation. Front Aging Neurosci. 2010 May 18;2:16. PubMed PMID: 20559464; PubMed Central PMCID: PMC2887037.
3: Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. Dev Neurosci. 2010 Jul;32(2):101-13. Epub 2010 May 4. PubMed PMID: 20453463.
4: Bain JM, Ziegler A, Yang Z, Levison SW, Sen E. TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the "brain marrow" in a rodent model of neonatal encephalopathy. PLoS One. 2010 Mar 5;5(3):e9567. PubMed PMID: 20221422; PubMed Central PMCID: PMC2832687.
5: Balzer E, Heine C, Jiang Q, Lee VM, Moss EG. LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro. Development. 2010 Mar;137(6):891-900. PubMed PMID: 20179095.
6: Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI. Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors. PLoS One. 2010 Feb 9;5(2):e9121. PubMed PMID: 20161753; PubMed Central PMCID: PMC2817745.
7: Abrajano JJ, Qureshi IA, Gokhan S, Zheng D, Bergman A, Mehler MF. Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PLoS One. 2009 Nov 3;4(11):e7665. PubMed PMID: 19888342; PubMed Central PMCID: PMC2766030.
8: Kawase-Koga Y, Otaegi G, Sun T. Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn. 2009 Nov;238(11):2800-12. PubMed PMID: 19806666; PubMed Central PMCID: PMC2831750.
9: Reinhard J, Horvat-Br√∂cker A, Illes S, Zaremba A, Knyazev P, Ullrich A, Faissner A. Protein tyrosine phosphatases expression during development of mouse superior colliculus. Exp Brain Res. 2009 Dec;199(3-4):279-97. Epub 2009 Sep 1. PubMed PMID: 19727691; PubMed Central PMCID: PMC2845883.
10: Bandeira F, Lent R, Herculano-Houzel S. Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14108-13. Epub 2009 Aug 4. PubMed PMID: 19666520; PubMed Central PMCID: PMC2729028.
11: Rom√°n-Trufero M, M√©ndez-G√≥mez HR, P√©rez C, Hijikata A, Fujimura Y, Endo T, Koseki H, Vicario-Abej√≥n C, Vidal M. Maintenance of undifferentiated state and self-renewal of embryonic neural stem cells by Polycomb protein Ring1B. Stem Cells. 2009 Jul;27(7):1559-70. PubMed PMID: 19544461.
12: Wu C, Chang A, Smith MC, Won R, Yin X, Staugaitis SM, Agamanolis D, Kidd GJ, Miller RH, Trapp BD. Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. J Neurosci. 2009 Jun 17;29(24):7649-57. PubMed PMID: 19535576; PubMed Central PMCID: PMC2742370.
13: Gupta MK, Papay RS, Jurgens CW, Gaivin RJ, Shi T, Doze VA, Perez DM. alpha1-Adrenergic receptors regulate neurogenesis and gliogenesis. Mol Pharmacol. 2009 Aug;76(2):314-26. Epub 2009 Jun 1. PubMed PMID: 19487244; PubMed Central PMCID: PMC2713124.
14: Perez JA, Clinton SM, Turner CA, Watson SJ, Akil H. A new role for FGF2 as an endogenous inhibitor of anxiety. J Neurosci. 2009 May 13;29(19):6379-87. PubMed PMID: 19439615; PubMed Central PMCID: PMC2748795.
15: Wilczynska KM, Singh SK, Adams B, Bryan L, Rao RR, Valerie K, Wright S, Griswold-Prenner I, Kordula T. Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytes. Stem Cells. 2009 May;27(5):1173-81. PubMed PMID: 19418463.
16: Bennett L, Yang M, Enikolopov G, Iacovitti L. Circumventricular organs: a novel site of neural stem cells in the adult brain. Mol Cell Neurosci. 2009 Jul;41(3):337-47. Epub 2009 May 3. PubMed PMID: 19409493; PubMed Central PMCID: PMC2697272.
17: Ho MS, Chen H, Chen M, Jacques C, Giangrande A, Chien CT. Gcm protein degradation suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6778-83. Epub 2009 Apr 3. PubMed PMID: 19346490; PubMed Central PMCID: PMC2672493.
18: Lasiene J, Matsui A, Sawa Y, Wong F, Horner PJ. Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes. Aging Cell. 2009 Apr;8(2):201-13. PubMed PMID: 19338498; PubMed Central PMCID: PMC2703583.
19: Kim HM, Hwang DH, Lee JE, Kim SU, Kim BG. Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS One. 2009;4(3):e4987. Epub 2009 Mar 25. PubMed PMID: 19319198; PubMed Central PMCID: PMC2656622.
20: Herrera F, Chen Q, Fischer WH, Maher P, Schubert DR. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. Cell Death Differ. 2009 Jun;16(6):910-20. Epub 2009 Mar 13. PubMed PMID: 19282871; PubMed Central PMCID: PMC2807404.
21: Borodovsky N, Ponomaryov T, Frenkel S, Levkowitz G. Neural protein Olig2 acts upstream of the transcriptional regulator Sim1 to specify diencephalic dopaminergic neurons. Dev Dyn. 2009 Apr;238(4):826-34. PubMed PMID: 19253397.
22: Nelson BR, Hartman BH, Ray CA, Hayashi T, Bermingham-McDonogh O, Reh TA. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn. 2009 Sep;238(9):2163-78. PubMed PMID: 19191219; PubMed Central PMCID: PMC2905851.
23: Oomen CA, Girardi CE, Cahyadi R, Verbeek EC, Krugers H, Jo√´ls M, Lucassen PJ. Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS One. 2009;4(1):e3675. Epub 2009 Jan 30. PubMed PMID: 19180242; PubMed Central PMCID: PMC2629844.
24: Mochizuki T, Bilitou A, Waters CT, Hussain K, Zollo M, Ohnuma S. Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1. Neural Dev. 2009 Jan 5;4:1. PubMed PMID: 19123928; PubMed Central PMCID: PMC2647920.
25: Nagao M, Campbell K, Burns K, Kuan CY, Trumpp A, Nakafuku M. Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. J Cell Biol. 2008 Dec 29;183(7):1243-57. PubMed PMID: 19114593; PubMed Central PMCID: PMC2606961.
26: Lin G, Goldman JE. An FGF-responsive astrocyte precursor isolated from the neonatal forebrain. Glia. 2009 Apr 15;57(6):592-603. PubMed PMID: 19031440; PubMed Central PMCID: PMC2657186.
27: Islam O, Gong X, Rose-John S, Heese K. Interleukin-6 and neural stem cells: more than gliogenesis. Mol Biol Cell. 2009 Jan;20(1):188-99. Epub 2008 Oct 29. PubMed PMID: 18971377; PubMed Central PMCID: PMC2613125.
28: King LA, Schwartz NB, Domowicz MS. Glial migratory streams in the developing hindbrain: a slice culture approach. J Neurosci Methods. 2009 Feb 15;177(1):30-43. Epub 2008 Oct 2. PubMed PMID: 18948137; PubMed Central PMCID: PMC2677068.
29: Kwon IS, Cho SK, Kim MJ, Tsai MJ, Mitsuda N, Suh-Kim H, Lee YD. Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells. Mol Cell Neurosci. 2009 Jan;40(1):50-61. Epub 2008 Sep 18. PubMed PMID: 18848628; PubMed Central PMCID: PMC2820303.
30: Wheeler SR, Stagg SB, Crews ST. Multiple Notch signaling events control Drosophila CNS midline neurogenesis, gliogenesis and neuronal identity. Development. 2008 Sep;135(18):3071-9. Epub 2008 Aug 13. PubMed PMID: 18701546; PubMed Central PMCID: PMC2744345.
31: Bhattacharya S, Das AV, Mallya KB, Ahmad I. Ciliary neurotrophic factor-mediated signaling regulates neuronal versus glial differentiation of retinal stem cells/progenitors by concentration-dependent recruitment of mitogen-activated protein kinase and Janus kinase-signal transducer and activator of transcription pathways in conjunction with Notch signaling. Stem Cells. 2008 Oct;26(10):2611-24. Epub 2008 Jul 31. PubMed PMID: 18669911.
32: Johansson S, Price J, Modo M. Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells. 2008 Sep;26(9):2444-54. Epub 2008 Jul 17. PubMed PMID: 18635871.
33: Peng H, Whitney N, Wu Y, Tian C, Dou H, Zhou Y, Zheng J. HIV-1-infected and/or immune-activated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiation. Glia. 2008 Jun;56(8):903-16. PubMed PMID: 18383342; PubMed Central PMCID: PMC2644639.
34: Ivkovic S, Canoll P, Goldman JE. Constitutive EGFR signaling in oligodendrocyte progenitors leads to diffuse hyperplasia in postnatal white matter. J Neurosci. 2008 Jan 23;28(4):914-22. PubMed PMID: 18216199; PubMed Central PMCID: PMC2711628.
35: Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S. Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem. 2008 Feb 29;283(9):5460-5. Epub 2007 Dec 31. PubMed PMID: 18167345.
36: Rodriguez S, Sickles HM, Deleonardis C, Alcaraz A, Gridley T, Lin DM. Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. Dev Biol. 2008 Feb 1;314(1):40-58. Epub 2007 Nov 28. PubMed PMID: 18155189; PubMed Central PMCID: PMC2374763.
37: Kim EJ, Leung CT, Reed RR, Johnson JE. In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis. J Neurosci. 2007 Nov 21;27(47):12764-74. PubMed PMID: 18032648.
38: Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci. 2007 Oct 17;27(42):11442-50. PubMed PMID: 17942739; PubMed Central PMCID: PMC2741502.
39: Costa MR, Kessaris N, Richardson WD, G√∂tz M, Hedin-Pereira C. The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J Neurosci. 2007 Oct 17;27(42):11376-88. PubMed PMID: 17942732.
40: Gan L, Qiao S, Lan X, Chi L, Luo C, Lien L, Yan Liu Q, Liu R. Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSw,Ind) mice. Neurobiol Dis. 2008 Jan;29(1):71-80. Epub 2007 Aug 21. PubMed PMID: 17916429; PubMed Central PMCID: PMC2180424.
41: Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest. 2007 Oct;117(10):2889-902. PubMed PMID: 17885687; PubMed Central PMCID: PMC1978427.
42: Soustelle L, Giangrande A. Novel gcm-dependent lineages in the postembryonic nervous system of Drosophila melanogaster. Dev Dyn. 2007 Aug;236(8):2101-8. PubMed PMID: 17654713.
43: Taylor MK, Yeager K, Morrison SJ. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development. 2007 Jul;134(13):2435-47. Epub 2007 May 30. PubMed PMID: 17537790; PubMed Central PMCID: PMC2653864.
44: Kimpel MW, Strother WN, McClintick JN, Carr LG, Liang T, Edenberg HJ, McBride WJ. Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. Alcohol. 2007 Mar;41(2):95-132. PubMed PMID: 17517326; PubMed Central PMCID: PMC1976291.
45: Rajkowska G, Miguel-Hidalgo JJ. Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets. 2007 Jun;6(3):219-33. Review. PubMed PMID: 17511618; PubMed Central PMCID: PMC2918806.
46: Strathmann FG, Wang X, Mayer-Pr√∂schel M. Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins. BMC Dev Biol. 2007 Apr 17;7:33. PubMed PMID: 17439658; PubMed Central PMCID: PMC1858687.
47: See J, Mamontov P, Ahn K, Wine-Lee L, Crenshaw EB 3rd, Grinspan JB. BMP signaling mutant mice exhibit glial cell maturation defects. Mol Cell Neurosci. 2007 May;35(1):171-82. Epub 2007 Feb 23. PubMed PMID: 17391983; PubMed Central PMCID: PMC1950488.
48: Hachem S, Laurenson AS, Hugnot JP, Legraverend C. Expression of S100B during embryonic development of the mouse cerebellum. BMC Dev Biol. 2007 Mar 15;7:17. PubMed PMID: 17362503; PubMed Central PMCID: PMC1832187.
49: Nait-Oumesmar B, Picard-Riera N, Kerninon C, Decker L, Seilhean D, H√∂glinger GU, Hirsch EC, Reynolds R, Baron-Van Evercooren A. Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4694-9. Epub 2007 Mar 8. PubMed PMID: 17360586.
50: Sugimori M, Nagao M, Bertrand N, Parras CM, Guillemot F, Nakafuku M. Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development. 2007 Apr;134(8):1617-29. Epub 2007 Mar 7. PubMed PMID: 17344230.
51: Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H. Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord. Stem Cells. 2007 Jun;25(6):1410-22. Epub 2007 Mar 1. PubMed PMID: 17332510.
52: Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum Mol Genet. 2007 Mar 15;16(6):651-66. Epub 2007 Feb 19. PubMed PMID: 17309880.
53: Cz√©h B, M√ºller-Keuker JI, Rygula R, Abumaria N, Hiemke C, Domenici E, Fuchs E. Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology. 2007 Jul;32(7):1490-503. Epub 2006 Dec 13. PubMed PMID: 17164819.
54: Djavadian R, Bisti S, Maccarone R, Bartkowska K, Turlejski K. Development and plasticity of the retina in the opossum Monodelphis domestica. Acta Neurobiol Exp (Wars). 2006;66(3):179-88. PubMed PMID: 17133949.
55: Uittenbogaard M, Martinka DL, Johnson PF, Vinson C, Chiaramello A. 5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites. J Neurosci Res. 2007 Jan;85(1):1-18. PubMed PMID: 17075921; PubMed Central PMCID: PMC2767119.
56: S√∂lter M, Locker M, Boy S, Taelman V, Bellefroid EJ, Perron M, Pieler T. Characterization and function of the bHLH-O protein XHes2: insight into the mechanisms controlling retinal cell fate decision. Development. 2006 Oct;133(20):4097-108. PubMed PMID: 17008450.
57: Covacu R, Danilov AI, Rasmussen BS, Hall√©n K, Moe MC, Lobell A, Johansson CB, Svensson MA, Olsson T, Brundin L. Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis. Stem Cells. 2006 Dec;24(12):2792-800. Epub 2006 Aug 17. PubMed PMID: 16916924.
58: Horky LL, Galimi F, Gage FH, Horner PJ. Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol. 2006 Oct 1;498(4):525-38. PubMed PMID: 16874803; PubMed Central PMCID: PMC2553041.
59: Stricker SH, Meiri K, G√∂tz M. P-GAP-43 is enriched in horizontal cell divisions throughout rat cortical development. Cereb Cortex. 2006 Jul;16 Suppl 1:i121-31. PubMed PMID: 16766698.
60: Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND. Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells. 2006 Aug;24(8):1908-13. Epub 2006 Apr 20. PubMed PMID: 16627686.
61: Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1551-6. Epub 2006 Jan 23. PubMed PMID: 16432183; PubMed Central PMCID: PMC1345718.
62: Ota M, Ito K. BMP and FGF-2 regulate neurogenin-2 expression and the differentiation of sensory neurons and glia. Dev Dyn. 2006 Mar;235(3):646-55. PubMed PMID: 16425218.
63: Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH. Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):780-5. Epub 2006 Jan 9. PubMed PMID: 16407118; PubMed Central PMCID: PMC1325968.
64: Sakurai M, Ayukawa K, Setsuie R, Nishikawa K, Hara Y, Ohashi H, Nishimoto M, Abe T, Kudo Y, Sekiguchi M, Sato Y, Aoki S, Noda M, Wada K. Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. J Cell Sci. 2006 Jan 1;119(Pt 1):162-71. PubMed PMID: 16371654.
65: Sailer MH, Hazel TG, Panchision DM, Hoeppner DJ, Schwab ME, McKay RD. BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells. J Cell Sci. 2005 Dec 15;118(Pt 24):5849-60. PubMed PMID: 16339968.
66: Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N. Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15983-8. Epub 2005 Oct 20. PubMed PMID: 16239343; PubMed Central PMCID: PMC1276098.
67: Bosco A, Cusato K, Nicchia GP, Frigeri A, Spray DC. A developmental switch in the expression of aquaporin-4 and Kir4.1 from horizontal to M√ºller cells in mouse retina. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3869-75. PubMed PMID: 16186376.
68: Fukushima N, Kato T, Li Z, Yokouchi K, Moriizumi T. Adult neurogenesis and gliogenesis in the rat olfactory nervous system. Chem Senses. 2005 Jan;30 Suppl 1:i113-4. PubMed PMID: 15738065.
69: Aguirre A, Gallo V. Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone. J Neurosci. 2004 Nov 17;24(46):10530-41. Erratum in: J Neurosci. 2004 Dec 1;24(48):1 p following 10973. PubMed PMID: 15548668.
70: Hashemolhosseini S, Wegner M. Impacts of a new transcription factor family: mammalian GCM proteins in health and disease. J Cell Biol. 2004 Sep 13;166(6):765-8. Epub 2004 Sep 7. Review. PubMed PMID: 15353544; PubMed Central PMCID: PMC2172107.
71: Wakamatsu Y. Understanding glial differentiation in vertebrate nervous system development. Tohoku J Exp Med. 2004 Aug;203(4):233-40. Review. PubMed PMID: 15297728.
72: Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y, Ikenaka K. The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes. Development. 2003 Dec;130(24):6027-35. Epub 2003 Oct 22. PubMed PMID: 14573516.
73: Stolt CC, Lommes P, Sock E, Chaboissier MC, Schedl A, Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003 Jul 1;17(13):1677-89. PubMed PMID: 12842915; PubMed Central PMCID: PMC196138.
74: Mao L, Wang JQ. Adult neural stem/progenitor cells in neurodegenerative repair. Sheng Li Xue Bao. 2003 Jun 25;55(3):233-44. PubMed PMID: 12817287.
75: Wu Y, Liu Y, Levine EM, Rao MS. Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Dev Dyn. 2003 Apr;226(4):675-89. PubMed PMID: 12666205.
76: Ajo R, Cacicedo L, Navarro C, S√°nchez-Franco F. Growth hormone action on proliferation and differentiation of cerebral cortical cells from fetal rat. Endocrinology. 2003 Mar;144(3):1086-97. PubMed PMID: 12586785.
77: Marshall CA, Goldman JE. Subpallial dlx2-expressing cells give rise to astrocytes and oligodendrocytes in the cerebral cortex and white matter. J Neurosci. 2002 Nov 15;22(22):9821-30. PubMed PMID: 12427838.
78: Qiao D, Seidler FJ, Padilla S, Slotkin TA. Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? Environ Health Perspect. 2002 Nov;110(11):1097-103. PubMed PMID: 12417480; PubMed Central PMCID: PMC1241065.
79: Rehberg S, Lischka P, Glaser G, Stamminger T, Wegner M, Rosorius O. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002 Aug;22(16):5826-34. PubMed PMID: 12138193; PubMed Central PMCID: PMC133963.
80: Egger B, Leemans R, Loop T, Kammermeier L, Fan Y, Radimerski T, Strahm MC, Certa U, Reichert H. Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. Development. 2002 Jul;129(14):3295-309. PubMed PMID: 12091301.
81: Umesono Y, Hiromi Y, Hotta Y. Context-dependent utilization of Notch activity in Drosophila glial determination. Development. 2002 May;129(10):2391-9. PubMed PMID: 11973271.
82: L√ºtolf S, Radtke F, Aguet M, Suter U, Taylor V. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development. 2002 Jan;129(2):373-85. PubMed PMID: 11807030.
83: Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, Walker L, Staufenbiel M, Jucker M. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. J Neurosci. 2002 Jan 15;22(2):515-22. PubMed PMID: 11784797.
84: Valli√®res L, Campbell IL, Gage FH, Sawchenko PE. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci. 2002 Jan 15;22(2):486-92. PubMed PMID: 11784794.
85: Sock E, Schmidt K, Hermanns-Borgmeyer I, B√∂sl MR, Wegner M. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol Cell Biol. 2001 Oct;21(20):6951-9. PubMed PMID: 11564878; PubMed Central PMCID: PMC99871.
86: Kammerer M, Giangrande A. Glide2, a second glial promoting factor in Drosophila melanogaster. EMBO J. 2001 Sep 3;20(17):4664-73. PubMed PMID: 11532931; PubMed Central PMCID: PMC125586.
87: Ohtsuka T, Sakamoto M, Guillemot F, Kageyama R. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J Biol Chem. 2001 Aug 10;276(32):30467-74. Epub 2001 Jun 8. PubMed PMID: 11399758.
88: Vetter ML, Moore KB. Becoming glial in the neural retina. Dev Dyn. 2001 Jun;221(2):146-53. Review. PubMed PMID: 11376483.
89: Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5868-73. Epub 2001 May 1. PubMed PMID: 11331769; PubMed Central PMCID: PMC33305.
90: Perfilieva E, Risedal A, Nyberg J, Johansson BB, Eriksson PS. Gender and strain influence on neurogenesis in dentate gyrus of young rats. J Cereb Blood Flow Metab. 2001 Mar;21(3):211-7. PubMed PMID: 11295875.
91: Van De Bor V, Giangrande A. Notch signaling represses the glial fate in fly PNS. Development. 2001 Apr;128(8):1381-90. PubMed PMID: 11262238.
92: Hatakeyama J, Tomita K, Inoue T, Kageyama R. Roles of homeobox and bHLH genes in specification of a retinal cell type. Development. 2001 Apr;128(8):1313-22. PubMed PMID: 11262232.
93: Scheer N, Groth A, Hans S, Campos-Ortega JA. An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development. 2001 Apr;128(7):1099-107. PubMed PMID: 11245575.
94: Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS. Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors. Development. 2001 Mar;128(5):689-702. PubMed PMID: 11171394.
95: Satow T, Bae SK, Inoue T, Inoue C, Miyoshi G, Tomita K, Bessho Y, Hashimoto N, Kageyama R. The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. J Neurosci. 2001 Feb 15;21(4):1265-73. PubMed PMID: 11160397.
96: Tomita K, Moriyoshi K, Nakanishi S, Guillemot F, Kageyama R. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 2000 Oct 16;19(20):5460-72. PubMed PMID: 11032813; PubMed Central PMCID: PMC314003.
97: Harroch S, Palmeri M, Rosenbluth J, Custer A, Okigaki M, Shrager P, Blum M, Buxbaum JD, Schlessinger J. No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta. Mol Cell Biol. 2000 Oct;20(20):7706-15. PubMed PMID: 11003666; PubMed Central PMCID: PMC86347.
98: Ha√Øk S, Gauthier LR, Granotier C, Peyrin JM, Lages CS, Dormont D, Boussin FD. Fibroblast growth factor 2 up regulates telomerase activity in neural precursor cells. Oncogene. 2000 Jun 15;19(26):2957-66. PubMed PMID: 10871847.
99: Hojo M, Ohtsuka T, Hashimoto N, Gradwohl G, Guillemot F, Kageyama R. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development. 2000 Jun;127(12):2515-22. PubMed PMID: 10821751.
100: Schreiber J, Riethmacher-Sonnenberg E, Riethmacher D, Tuerk EE, Enderich J, B√∂sl MR, Wegner M. Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. Mol Cell Biol. 2000 Apr;20(7):2466-74. PubMed PMID: 10713170; PubMed Central PMCID: PMC85439.
101: Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 1999 Sep;126(18):4027-37. PubMed PMID: 10457012.
102: Adams MM, Flagg RA, Gore AC. Perinatal changes in hypothalamic N-methyl-D-aspartate receptors and their relationship to gonadotropin-releasing hormone neurons. Endocrinology. 1999 May;140(5):2288-96. PubMed PMID: 10218982.
103: Morrow EM, Furukawa T, Lee JE, Cepko CL. NeuroD regulates multiple functions in the developing neural retina in rodent. Development. 1999 Jan;126(1):23-36. PubMed PMID: 9834183.
104: Marmur R, Kessler JA, Zhu G, Gokhan S, Mehler MF. Differentiation of oligodendroglial progenitors derived from cortical multipotent cells requires extrinsic signals including activation of gp130/LIFbeta receptors. J Neurosci. 1998 Dec 1;18(23):9800-11. PubMed PMID: 9822739.
105: Miller AA, Bernardoni R, Giangrande A. Positive autoregulation of the glial promoting factor glide/gcm. EMBO J. 1998 Nov 2;17(21):6316-26. PubMed PMID: 9799239; PubMed Central PMCID: PMC1170956.
106: Bernardoni R, Miller AA, Giangrande A. Glial differentiation does not require a neural ground state. Development. 1998 Aug;125(16):3189-200. PubMed PMID: 9671591.
107: Sakakibara S, Okano H. Expression of neural RNA-binding proteins in the postnatal CNS: implications of their roles in neuronal and glial cell development. J Neurosci. 1997 Nov 1;17(21):8300-12. PubMed PMID: 9334405.
108: Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science. 1997 Oct 17;278(5337):477-83. PubMed PMID: 9334309.
109: MacFarlane SN, Sontheimer H. Electrophysiological changes that accompany reactive gliosis in vitro. J Neurosci. 1997 Oct 1;17(19):7316-29. PubMed PMID: 9295378.
110: Mabie PC, Mehler MF, Marmur R, Papavasiliou A, Song Q, Kessler JA. Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cells. J Neurosci. 1997 Jun 1;17(11):4112-20. PubMed PMID: 9151728.
111: Schreiber J, Sock E, Wegner M. The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4739-44. PubMed PMID: 9114061; PubMed Central PMCID: PMC20794.
112: Sutherland ML, Delaney TA, Noebels JL. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS. J Neurosci. 1996 Apr 1;16(7):2191-207. PubMed PMID: 8601800.
113: Jaworski DM, Kelly GM, Hockfield S. The CNS-specific hyaluronan-binding protein BEHAB is expressed in ventricular zones coincident with gliogenesis. J Neurosci. 1995 Feb;15(2):1352-62. PubMed PMID: 7869103.
114: Giangrande A. Proneural genes influence gliogenesis in Drosophila. Development. 1995 Feb;121(2):429-38. PubMed PMID: 7768184.
115: Gallo V, Armstrong RC. Developmental and growth factor-induced regulation of nestin in oligodendrocyte lineage cells. J Neurosci. 1995 Jan;15(1 Pt 1):394-406. PubMed PMID: 7823144.
116: Campbell G, G√∂ring H, Lin T, Spana E, Andersson S, Doe CQ, Tomlinson A. RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. Development. 1994 Oct;120(10):2957-66. PubMed PMID: 7607085.
117: Nye JS, Kopan R, Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development. 1994 Sep;120(9):2421-30. PubMed PMID: 7956822.
118: Levison SW, Chuang C, Abramson BJ, Goldman JE. The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated. Development. 1993 Nov;119(3):611-22. PubMed PMID: 8187632.
119: Giangrande A, Murray MA, Palka J. Development and organization of glial cells in the peripheral nervous system of Drosophila melanogaster. Development. 1993 Mar;117(3):895-904. PubMed PMID: 8325244.
120: Stofer WD, Horn JP. Neurogenesis and differentiation of sympathetic B and C cells in the bullfrog tadpole. J Neurosci. 1993 Feb;13(2):801-7. PubMed PMID: 8426237.
121: Miller RH, Szigeti V. Clonal analysis of astrocyte diversity in neonatal rat spinal cord cultures. Development. 1991 Sep;113(1):353-62. PubMed PMID: 1765006.
122: Schlosshauer B. Neurothelin: molecular characteristics and developmental regulation in the chick CNS. Development. 1991 Sep;113(1):129-40. PubMed PMID: 1764990.
123: Sturrock RR. A quantitative histological study of cell division and changes in cell number in the meningeal sheath of the embryonic human optic nerve. J Anat. 1987 Dec;155:133-40. PubMed PMID: 3503045; PubMed Central PMCID: PMC1261881.
124: Trujillo CM, Yanes CM, Marrero A, Perez MA, Martin JM. Cell death in the embryonic brain of Gallotia galloti (Reptilia; Lacertidae): a structural and ultrastructural study. J Anat. 1987 Feb;150:11-21. PubMed PMID: 3654326; PubMed Central PMCID: PMC1261660.
125: Giulian D, Allen RL, Baker TJ, Tomozawa Y. Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous system. J Cell Biol. 1986 Mar;102(3):803-11. PubMed PMID: 3949880; PubMed Central PMCID: PMC2114119.
126: Cima C, Grant P. Development of the optic nerve in Xenopus laevis. II. Gliogenesis, myelination and metamorphic remodelling. J Embryol Exp Morphol. 1982 Dec;72:251-67. PubMed PMID: 7183742.
127: Sturrock RR. Gliogenesis in the prenatal rabbit spinal cord. J Anat. 1982 Jun;134(Pt 4):771-93. PubMed PMID: 7130040; PubMed Central PMCID: PMC1167870.
128: Sturrock RR. Development of the indusium griseum. II. A semithin light microscopic and electron microscopic study. J Anat. 1978 Mar;125(Pt 3):433-45. PubMed PMID: 640951; PubMed Central PMCID: PMC1235615.
129: Sturrock RR. Histogenesis of the anterior limb of the anterior commissure of the mouse brain. 3. An electron microscopic study of gliogenesis. J Anat. 1974 Feb;117(Pt 1):37-53. PubMed PMID: 4844650; PubMed Central PMCID: PMC1231432.