Stem Cells - Placental Cord Blood

From Embryology
Embryology - 13 Dec 2018    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Blood stem cells
Blood stem cells

Placenta and placental cord blood (umbilical cord blood, UCB) contains stem cells that can be harvested at birth (More? Placenta Development). The total amout of blood that can be collected is about 90 ml, from which stem cells can be collected, typed and stored in Cord Blood Banks. Both public and private Cord Blood Banks have arisen in this area. These cells provide a resource for bone marrow replacement therapy in many diseases, bone marrow transplantation was originally the only treatment available for many otherwise fatal diseases. Recently, cord blood transplantation has developed as a new alternative therapy for some of these same diseases.


Placental cord blood is a rich souce of haematopoietic stem cells for transplantation. Cord blood can collected at birth, with no impact on the mother or neonate, and stured in cord blood banks for later use.


BBC (UK) A brief article on Cord Blood stem cells and their therapeutic potential.


A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) Stem Cells: A Primer (PDF 1.89 MB) and more recently NIH has established a Stem Cell information page.

Links: Blood Development | Placenta Development
Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Category:Stem Cell

Some Recent Findings

  • On the Value of the Umbilical Cord Blood Supply[1] "Several public cord blood banks are struggling financially, and the question remains as to whether additional allocations of funds to them are justified. To estimate the social benefits of public cord blood bank inventory net of cord blood banks' operational costs. We used publicly available data from the Health Resources and Service Administration on the number of annual cord blood transplants as well as the patient age distribution in 2010, and the survival estimates between 2008 and 2012 for the several diseases treated by cord blood transplantation. Data on aggregate annual costs to the cord blood industry for recruitment, processing, and storage were obtained from published work. We used estimated increases in life expectancy due to treatment using umbilical cord blood and value for life-years gained to estimate the social benefits of the public cord blood inventory annually. We found that the annual social benefits of between $500 million and $1.5 billion outweigh the current operational annual costs of running cord blood banks of $60 to $70 million by a significant margin."
  • Trends in cord blood banking[2] "Umbilical cord blood (UCB) is a source of hematopoietic precursor cells for transplantation. The creation of UCB banks in 1992 led to the possibility of storing units of UCB for unrelated transplants. The distribution of cell contents in historical inventories is not homogenous and many units are not, therefore, suitable for adults. The aim of this study was to analyse our UCB bank inventory, evaluate the units released for transplantation and calculate the cost of the current process per unit of UCB stored."
  • Reprogramming of Human Umbilical Cord Stromal Mesenchymal Stem Cells for Myogenic Differentiation and Muscle Repair[3] "Human umbilical cord stromal mesenchymal stem cells (hUCS-MSCs) have the potential to differentiate into numerous cell types including epithelial cells, neurons and hepatocytes in vitro, in addition to mesenchyme-derived cells such as osteocytes, chondrocytes and adipocytes. One important property of these cells is the lack of type II major histocompatibility complex class molecules, thus allowing them to be considered as an excellent candidate for transplantations."
  • Human umbilical cord blood treatment in a mouse model of ALS[4] "...These results demonstrate that treatment for ALS with an appropriate dose of MNC hUCB cells may provide a neuroprotective effect for motor neurons through active involvement of these cells in modulating the host immune inflammatory system response."
  • Umbilical cord blood transplantation for myeloid malignancies[5] "Umbilical cord blood is a valuable alternative source of hematopoietic stem cells for transplantation of patients with myeloid malignancies who need an allogeneic transplant, but lack a suitable sibling donor."
More recent papers  
Mark Hill.jpg
PubMed logo.gif

This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Cord Stem Cell

John B Patton, Sasisekhar Bennuru, Mark L Eberhard, Jessica A Hess, April Torigian, Sara Lustigman, Thomas B Nutman, David Abraham Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. PLoS Negl Trop Dis: 2018, 12(12);e0006977 PubMed 30540742

Yongting Zhang, Yuwen Li, Wenting Li, Jie Cai, Ming Yue, Longfeng Jiang, Ruirui Xu, Lili Zhang, Jun Li, Chuanlong Zhu Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats. Stem Cells Int: 2018, 2018;7159465 PubMed 30538751

Laya Takbiri Osgoei, Kazem Parivar, Marzieh Ebrahimi, Esmaeil Mortaz Nicotine Modulates the Release of Inflammatory Cytokines and Expression of TLR2, TLR4 of Cord Blood Mononuclear Cells. Iran J Allergy Asthma Immunol: 2018, 17(4);372-378 PubMed 30537800

Anat Shemer, Jonathan Grozovski, Tuan Leng Tay, Jenhan Tao, Alon Volaski, Patrick Süß, Alberto Ardura-Fabregat, Mor Gross-Vered, Jung-Seok Kim, Eyal David, Louise Chappell-Maor, Lars Thielecke, Christopher K Glass, Kerstin Cornils, Marco Prinz, Steffen Jung Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun: 2018, 9(1);5206 PubMed 30523248

C E Neunert, J M Despotovic Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature. Pediatr Blood Cancer: 2018;e27569 PubMed 30537439

Cord Blood Registries

Placental cord blood banks 2009.jpg

Placental cord blood banks (2009)[6]


Cord blood collection statistics began in 1994 and have been increasing ever since. In January 2007, there were 254,000 cord blood units collected in worldwide registries.


Cord Blood Units Register (Data from: Bone Marrow Donors Worldwide Cord Blood Registries)

CBU Cord Blood Units

NVC Net Volume Collected of CBU Volume of the unit in milliliters; see note below.

TNC Total Nucleated Cells count of CBU The rounded number of nucleated cells in the units of 10 million.

CD34P Collected number of CD34+ cells of CBU Cell count after volume reduction; numeric value with decimal point in units of 1 million.

MONONUC Collected number of mononuclear cells of CBU The rounded number of mononuclear cells in the units of 10 million.

Diseases

The list of diseases that were transplanted with cord blood include the following: Acute Lymphoblastic Leukaemia, Acute Myeloblastic Leukaemia, Adrenoleukodystrophy, Blackfan-Diamond, Cancer-miscellaneous, Chronic Myeloid Leukaemia, Chronic Lymphocytic leukaemia, Fanconi's Anaemia, Genetic disorders - miscellaneous, Hurler's Syndrome, Immune deficiency-Miscellaneous, Krabbe's disease, Lymphomas, Myelodysplastic Syndrome, Mucolipopolysaccharide deficiency, Osteopetrosis, Syndrome Severe Aplastic Anaemia, Severe Combined Immunodeficiency Disease, Storage disorders, Thalassaemia, Wiskott-Aldrich Syndrome (From: The Sydney Cord Blood Bank)

Australia

Australia has three cord blood banks (CBBs) located in Brisbane (Queensland), Sydney (New South Wales) and Melbourne (Victoria). AusCord is the Australian national network of umbilical cord blood banks and cord blood collection centres.

Links: Australian Bone Marrow Donor Registry | The Sydney Cord Blood Bank (SCBB) | Melbourne - BMDI Cord Blood Bank | Queensland Cord Blood Bank | PDF - AusCord Brochure

United States

On August 9, 2001, at 9:00 p.m. EDT, the President announced his decision to allow Federal funds to be used for research on existing human embryonic stem cell lines as long as prior to his announcement (1) the derivation process (which commences with the removal of the inner cell mass from the blastocyst) had already been initiated and (2) the embryo from which the stem cell line was derived no longer had the possibility of development as a human being.

In addition, the President established the following criteria that must be met:

  • The stem cells must have been derived from an embryo that was created for reproductive purposes;
  • The embryo was no longer needed for these purposes;
  • Informed consent must have been obtained for the donation of the embryo;
  • No financial inducements were provided for donation of the embryo.

In order to facilitate research using human embryonic stem cells, the NIH is creating a Human Embryonic Stem Cell Registry that will list the human embryonic stem cell lines -- at varying stages of development -- that meet the eligibility criteria. Listed below are entities that have developed stem cell lines that meet the President's criteria and are therefore eligible for federal funding. Please click on the name of the laboratory or company for contact information.

Dartmouth ethics professor discusses promise and pitfalls of stem cell research (2005)

NIH Clinical Trials (May 2004) Launches Study of Hematopoietic Stem Cell Transplantation for Severe, Treatment-Resistant Lupus (NIAMS, May 13,2004)

A clinical therapeutic trial in the USA for hematopoietic stem cells in an autoimmune disease.

"A five-year study to see whether a therapy using transplantation of hematopoietic stem cells, blood stem cells found in bone marrow, can produce long-term remission for patients with severe, treatment-resistant systemic lupus erythematosus (or lupus), a rheumatic autoimmune disease that can affect the body's major organs. The study will include a basic research component to examine the roles of B and T cells, white blood cells in the immune system, in triggering lupus symptoms."

Read more of the NIH Press Release

Note that a May search of NIH Clinical Trials with "stem cell" found 302 study results.

Repeat search: NIH Clinical Trials with "stem cell"

A recent paper has also identified SP cells in ovarian cancer which have properties similar to stem cells.[7]

References

  1. Strong A, Gračner T, Chen P & Kapinos K. (2018). On the Value of the Umbilical Cord Blood Supply. Value Health , 21, 1077-1082. PMID: 30224112 DOI.
  2. Arrojo IP, Lamas Mdel C, Verdugo LP, Alfaro PR, Pena RR, Gordo FS, Maldonado PG & Gémar GG. (2012). Trends in cord blood banking. Blood Transfus , 10, 95-100. PMID: 22153685 DOI.
  3. Kocaefe C, Balci D, Hayta BB & Can A. (2010). Reprogramming of human umbilical cord stromal mesenchymal stem cells for myogenic differentiation and muscle repair. Stem Cell Rev , 6, 512-22. PMID: 20665127 DOI.
  4. Garbuzova-Davis S, Sanberg CD, Kuzmin-Nichols N, Willing AE, Gemma C, Bickford PC, Miller C, Rossi R & Sanberg PR. (2008). Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PLoS ONE , 3, e2494. PMID: 18575617 DOI.
  5. Brunstein CG, Baker KS & Wagner JE. (2007). Umbilical cord blood transplantation for myeloid malignancies. Curr. Opin. Hematol. , 14, 162-9. PMID: 17255794 DOI.
  6. McKenna D & Sheth J. (2011). Umbilical cord blood: current status & promise for the future. Indian J. Med. Res. , 134, 261-9. PMID: 21985808
  7. Moore KA & Lemischka IR. (2006). Stem cells and their niches. Science , 311, 1880-5. PMID: 16574858 DOI.

Journals

  • Cell Stem Cell is the official affiliated journal of the International Society for Stem Cell Research (ISSCR).
  • Stem Cells welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The journal covers all aspects of stem cells: embryonic stem cells; tissue-specific stem cells; cancer stem cells; the stem cell niche; stem cell genomics and proteomics; and translational and clinical researc

Reviews

Sanchez-Ramos J. (2006). Stem cells from umbilical cord blood. Semin. Reprod. Med. , 24, 358-69. PMID: 17123231 DOI.

O'Brien TA, Tiedemann K & Vowels MR. (2006). No longer a biological waste product: umbilical cord blood. Med. J. Aust. , 184, 407-10. PMID: 16618241

Brunstein CG & Wagner JE. (2006). Umbilical cord blood transplantation and banking. Annu. Rev. Med. , 57, 403-17. PMID: 16409157 DOI.

Saulnier N, Di Campli C, Zocco MA, Di Gioacchino G, Novi M & Gasbarrini A. (2005). From stem cell to solid organ. Bone marrow, peripheral blood or umbilical cord blood as favorable source?. Eur Rev Med Pharmacol Sci , 9, 315-24. PMID: 16479735

Articles

Garbuzova-Davis S, Sanberg CD, Kuzmin-Nichols N, Willing AE, Gemma C, Bickford PC, Miller C, Rossi R & Sanberg PR. (2008). Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PLoS ONE , 3, e2494. PMID: 18575617 DOI.

Brunstein CG, Baker KS & Wagner JE. (2007). Umbilical cord blood transplantation for myeloid malignancies. Curr. Opin. Hematol. , 14, 162-9. PMID: 17255794 DOI.

Rubinstein P. (2006). Why cord blood?. Hum. Immunol. , 67, 398-404. PMID: 16728260 DOI.

Search PubMed

July 2010 "cord stem cell" All (9884) Review (1260) Free Full Text (2357)


Search PubMed Now: cord stem cell | cord blood bank

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.




Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2018, December 13) Embryology Stem Cells - Placental Cord Blood. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Stem_Cells_-_Placental_Cord_Blood

What Links Here?
© Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G