Stem Cells - Placental Cord Blood

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Introduction

Blood stem cells
Blood stem cells

Placenta and placental cord blood (umbilical cord blood, UCB) contains stem cells that can be harvested at birth (More? Placenta Development). The total amout of blood that can be collected is about 90 ml, from which stem cells can be collected, typed and stored in Cord Blood Banks. Both public and private Cord Blood Banks have arisen in this area. These cells provide a resource for bone marrow replacement therapy in many diseases, bone marrow transplantation was originally the only treatment available for many otherwise fatal diseases. Recently, cord blood transplantation has developed as a new alternative therapy for some of these same diseases.


Placental cord blood is a rich souce of haematopoietic stem cells for transplantation. Cord blood can collected at birth, with no impact on the mother or neonate, and stured in cord blood banks for later use.


BBC (UK) A brief article on Cord Blood stem cells and their therapeutic potential.


A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) Stem Cells: A Primer (PDF 1.89 MB) and more recently NIH has established a Stem Cell information page.

Links: Blood Development | Placenta Development
Stem Cell Links: Introduction | Timeline | Placental Cord Blood | Adult | Induced | Yamanaka Factors | Somatic Cell Nuclear Transfer | Ethics | Category:Stem Cell

Some Recent Findings

  • Trends in cord blood banking[1] "Umbilical cord blood (UCB) is a source of hematopoietic precursor cells for transplantation. The creation of UCB banks in 1992 led to the possibility of storing units of UCB for unrelated transplants. The distribution of cell contents in historical inventories is not homogenous and many units are not, therefore, suitable for adults. The aim of this study was to analyse our UCB bank inventory, evaluate the units released for transplantation and calculate the cost of the current process per unit of UCB stored."
  • Reprogramming of Human Umbilical Cord Stromal Mesenchymal Stem Cells for Myogenic Differentiation and Muscle Repair [2] "Human umbilical cord stromal mesenchymal stem cells (hUCS-MSCs) have the potential to differentiate into numerous cell types including epithelial cells, neurons and hepatocytes in vitro, in addition to mesenchyme-derived cells such as osteocytes, chondrocytes and adipocytes. One important property of these cells is the lack of type II major histocompatibility complex class molecules, thus allowing them to be considered as an excellent candidate for transplantations."
  • Human umbilical cord blood treatment in a mouse model of ALS[3] "...These results demonstrate that treatment for ALS with an appropriate dose of MNC hUCB cells may provide a neuroprotective effect for motor neurons through active involvement of these cells in modulating the host immune inflammatory system response."
  • Umbilical cord blood transplantation for myeloid malignancies[4] "Umbilical cord blood is a valuable alternative source of hematopoietic stem cells for transplantation of patients with myeloid malignancies who need an allogeneic transplant, but lack a suitable sibling donor."
More recent papers
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
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References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Cord Stem Cell

Dah-Ching Ding, Yao-Tseng Wen, Rong-Kung Tsai Pigment epithelium-derived factor from ARPE19 promotes proliferation and inhibits apoptosis of human umbilical mesenchymal stem cells in serum-free medium. Exp. Mol. Med.: 2017, 49(12);e411 PubMed 29244789

Jun Ming Wan, Liang le Liu, Jian Fang Zhang, Jian Wei Lu, Qi Li Promotion of neuronal regeneration by using self-polymerized dendritic polypeptide scaffold for spinal cord tissue engineering. J Mater Sci Mater Med: 2017, 29(1);6 PubMed 29242993

Chen Hou, Danyi Peng, Li Gao, Daiyin Tian, Jihong Dai, Zhengxiu Luo, Enmei Liu, Hong Chen, Lin Zou, Zhou Fu Human umbilical cord-derived mesenchymal stem cells protect from hyperoxic lung injury by ameliorating aberrant elastin remodeling in the lung of O2-exposed newborn rat. Biochem. Biophys. Res. Commun.: 2017; PubMed 29242152

Lorenzo Di Cesare Mannelli, Barbara Tenci, Laura Micheli, Alessia Vona, Francesca Corti, Matteo Zanardelli, Andrea Lapucci, Ann Maria Clemente, Paola Failli, Carla Ghelardini Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation. Neuropharmacology: 2017; PubMed 29241656

Durai Murugan Muniswami, Indirani Kanakasabapathy, George Tharion Globose basal cells for spinal cord regeneration. Neural Regen Res: 2017, 12(11);1895-1904 PubMed 29239337

Cord Blood Registries

Placental cord blood banks 2009.jpg

Placental cord blood banks (2009)[5]


Cord blood collection statistics began in 1994 and have been increasing ever since. In January 2007, there were 254,000 cord blood units collected in worldwide registries.


Cord Blood Units Register (Data from: Bone Marrow Donors Worldwide Cord Blood Registries)

CBU Cord Blood Units

NVC Net Volume Collected of CBU Volume of the unit in milliliters; see note below.

TNC Total Nucleated Cells count of CBU The rounded number of nucleated cells in the units of 10 million.

CD34P Collected number of CD34+ cells of CBU Cell count after volume reduction; numeric value with decimal point in units of 1 million.

MONONUC Collected number of mononuclear cells of CBU The rounded number of mononuclear cells in the units of 10 million.

Diseases

The list of diseases that were transplanted with cord blood include the following: Acute Lymphoblastic Leukaemia, Acute Myeloblastic Leukaemia, Adrenoleukodystrophy, Blackfan-Diamond, Cancer-miscellaneous, Chronic Myeloid Leukaemia, Chronic Lymphocytic leukaemia, Fanconi's Anaemia, Genetic disorders - miscellaneous, Hurler's Syndrome, Immune deficiency-Miscellaneous, Krabbe's disease, Lymphomas, Myelodysplastic Syndrome, Mucolipopolysaccharide deficiency, Osteopetrosis, Syndrome Severe Aplastic Anaemia, Severe Combined Immunodeficiency Disease, Storage disorders, Thalassaemia, Wiskott-Aldrich Syndrome (From: The Sydney Cord Blood Bank)

Australia

Australia has three cord blood banks (CBBs) located in Brisbane (Queensland), Sydney (New South Wales) and Melbourne (Victoria). AusCord is the Australian national network of umbilical cord blood banks and cord blood collection centres.

Links: Australian Bone Marrow Donor Registry | The Sydney Cord Blood Bank (SCBB) | Melbourne - BMDI Cord Blood Bank | Queensland Cord Blood Bank | PDF - AusCord Brochure

United States

On August 9, 2001, at 9:00 p.m. EDT, the President announced his decision to allow Federal funds to be used for research on existing human embryonic stem cell lines as long as prior to his announcement (1) the derivation process (which commences with the removal of the inner cell mass from the blastocyst) had already been initiated and (2) the embryo from which the stem cell line was derived no longer had the possibility of development as a human being.

In addition, the President established the following criteria that must be met:

  • The stem cells must have been derived from an embryo that was created for reproductive purposes;
  • The embryo was no longer needed for these purposes;
  • Informed consent must have been obtained for the donation of the embryo;
  • No financial inducements were provided for donation of the embryo.

In order to facilitate research using human embryonic stem cells, the NIH is creating a Human Embryonic Stem Cell Registry that will list the human embryonic stem cell lines -- at varying stages of development -- that meet the eligibility criteria. Listed below are entities that have developed stem cell lines that meet the President's criteria and are therefore eligible for federal funding. Please click on the name of the laboratory or company for contact information.

Dartmouth ethics professor discusses promise and pitfalls of stem cell research (2005)

NIH Clinical Trials (May 2004) Launches Study of Hematopoietic Stem Cell Transplantation for Severe, Treatment-Resistant Lupus (NIAMS, May 13,2004)

A clinical therapeutic trial in the USA for hematopoietic stem cells in an autoimmune disease.

"A five-year study to see whether a therapy using transplantation of hematopoietic stem cells, blood stem cells found in bone marrow, can produce long-term remission for patients with severe, treatment-resistant systemic lupus erythematosus (or lupus), a rheumatic autoimmune disease that can affect the body's major organs. The study will include a basic research component to examine the roles of B and T cells, white blood cells in the immune system, in triggering lupus symptoms."

Read more of the NIH Press Release

Note that a May search of NIH Clinical Trials with "stem cell" found 302 study results.

Repeat search: NIH Clinical Trials with "stem cell"

A recent paper has also identified SP cells in ovarian cancer which have properties similar to stem cells.[6]

References

  1. Isidro Prat Arrojo, María del Carmen Hernández Lamas, Laura Ponce Verdugo, Pascual Rizo Alfaro, Rebeca Rodríguez Pena, Francisco Sánchez Gordo, Pilar Gómez Maldonado, Gracia García Gémar Trends in cord blood banking. Blood Transfus: 2012, 10(1);95-100 PubMed 22153685
  2. Cetin Kocaefe, Deniz Balci, Burcu Balci Hayta, Alp Can Reprogramming of human umbilical cord stromal mesenchymal stem cells for myogenic differentiation and muscle repair. Stem Cell Rev: 2010, 6(4);512-22 PubMed 20665127
  3. Svitlana Garbuzova-Davis, Cyndy Davis Sanberg, Nicole Kuzmin-Nichols, Alison E Willing, Carmelina Gemma, Paula C Bickford, Christina Miller, Robert Rossi, Paul R Sanberg Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PLoS ONE: 2008, 3(6);e2494 PubMed 18575617
  4. Claudio G Brunstein, K Scott Baker, John E Wagner Umbilical cord blood transplantation for myeloid malignancies. Curr. Opin. Hematol.: 2007, 14(2);162-9 PubMed 17255794
  5. David McKenna, Jayesh Sheth Umbilical cord blood: current status & promise for the future. Indian J. Med. Res.: 2011, 134;261-9 PubMed 21985808 | PMC3193706 | Indian J Med Res.
  6. Kateri A Moore, Ihor R Lemischka Stem cells and their niches. Science: 2006, 311(5769);1880-5 PubMed 16574858

Journals

  • Cell Stem Cell is the official affiliated journal of the International Society for Stem Cell Research (ISSCR).
  • Stem Cells welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The journal covers all aspects of stem cells: embryonic stem cells; tissue-specific stem cells; cancer stem cells; the stem cell niche; stem cell genomics and proteomics; and translational and clinical researc

Reviews

Juan Sanchez-Ramos Stem cells from umbilical cord blood. Semin. Reprod. Med.: 2006, 24(5);358-69 PubMed 17123231

Tracey A O'Brien, Karin Tiedemann, Marcus R Vowels No longer a biological waste product: umbilical cord blood. Med. J. Aust.: 2006, 184(8);407-10 PubMed 16618241

Claudio G Brunstein, John E Wagner Umbilical cord blood transplantation and banking. Annu. Rev. Med.: 2006, 57;403-17 PubMed 16409157

N Saulnier, C Di Campli, M A Zocco, G Di Gioacchino, M Novi, A Gasbarrini From stem cell to solid organ. Bone marrow, peripheral blood or umbilical cord blood as favorable source? Eur Rev Med Pharmacol Sci: 2006, 9(6);315-24 PubMed 16479735

Articles

Svitlana Garbuzova-Davis, Cyndy Davis Sanberg, Nicole Kuzmin-Nichols, Alison E Willing, Carmelina Gemma, Paula C Bickford, Christina Miller, Robert Rossi, Paul R Sanberg Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PLoS ONE: 2008, 3(6);e2494 PubMed 18575617

Claudio G Brunstein, K Scott Baker, John E Wagner Umbilical cord blood transplantation for myeloid malignancies. Curr. Opin. Hematol.: 2007, 14(2);162-9 PubMed 17255794

Pablo Rubinstein Why cord blood? Hum. Immunol.: 2006, 67(6);398-404 PubMed 16728260


Search PubMed

July 2010 "cord stem cell" All (9884) Review (1260) Free Full Text (2357)


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Cite this page: Hill, M.A. 2017 Embryology Stem Cells - Placental Cord Blood. Retrieved December 17, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Stem_Cells_-_Placental_Cord_Blood

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