File:Swapping mitochondrial DNA mammalian oocytes.jpg
Swapping mitochondrial DNA in mammalian oocytes
Technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby. (figure reference)
Working with rhesus macaque monkeys, Tachibana et al.:
- a - removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria. The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex).
- b - transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast).
- c - fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte.
- d - developing blastocyst was implanted in a surrogate mother.
- e - mother gave birth to a healthy baby.
- Shoubridge EA. (2009). Developmental biology: Asexual healing. Nature , 461, 354-5. PMID: 19759608 DOI.
- Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O & Mitalipov S. (2009). Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature , 461, 367-72. PMID: 19710649 DOI.
Nature 461, 354-355 (17 September 2009) | doi:10.1038/461354a; Published online 16 September 2009
Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html
Cite this page: Hill, M.A. (2019, February 18) Embryology Swapping mitochondrial DNA mammalian oocytes.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Swapping_mitochondrial_DNA_mammalian_oocytes.jpg
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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