File:Glomerular podocyte cartoon.jpg
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Stages of Glomerular Development
Emphasis on the role of the podocyte.
| S-shaped stage | Head-shaped stage | Capillary loop stage | Mature glomerulus |
|---|---|---|---|
| Developing podocytes acquire podocyte markers during the S-shaped stage of nephron development at which time blood vessels and mesenchyme invade (arrow). The podocytes (round nuclei) separate from the parietal epithelial cells (triangular nuclei) forming what will become Bowman's space. | at this stage of glomerular development, the glomerulus consists of a ball of cell surrounded by developing podocytes. | this stage of glomerular development includes the infolding of the surface layer in order to enlarge the area available for filtration as well as the development of foot processes that interdigitate between podocytes and abut the underlying GBM which is being synthesized as a collaboration between the podocyte and underlying endothelial and mesangial cells. | the mature glomerulus has maximized filtration surface area by developing intertwining finger-like projections coated by fenestrated endothelial cells on the inside, a specialized strong thin GBM in the middle, and interdigitating podocyte foot processes connected by slit diaphragms on the outer surface. |
- Links: Renal System Development
Reference
Wiggins RC. (2007). The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int. , 71, 1205-14. PMID: 17410103 DOI.
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Kidney Int.: 2007, 71(12);1205-14 PMID:17410103.
Original file name: Figure 2. 5002222f2.jpg http://www.nature.com/ki/journal/v71/n12/fig_tab/5002222f2.html
Cite this page: Hill, M.A. (2024, April 26) Embryology Glomerular podocyte cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Glomerular_podocyte_cartoon.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 15:20, 7 September 2017 | | 800 × 199 (19 KB) | Z8600021 (talk | contribs) | delete degenerative changes |
| 12:31, 19 July 2011 |  | 800 × 416 (68 KB) | S8600021 (talk | contribs) | ==Stages of glomerular development and progression with emphasis on the role of the podocyte== The S-shaped stage. Developing podocytes acquire podocyte markers during the S-shaped stage of nephron development at which time blood vessels and mesenchyme in |
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