File:Chicken- rhombomere boundary FGF3 expression.jpg

Chicken Rhombomere Boundary FGF3 expression

FGF3 - fibroblast growth factor 3 ss - somite stage

"Several soluble signals were shown to be localized to boundary cells of different species. For instance,Wnt1 and Wnt3a are expressed in zebrafish hindbrain boundaries, while fibroblast growth factor 3 (FGF3) and FGF19 are confined to mouse and chick hindbrain boundary cells, from around E10/Hamburger Hamilton stage 16, respectively. Some modulators or inhibitors of signaling systems, such as the TGFβ inhibitor follistatin and the Notch modulator radical fringe also accumulate at hindbrain boundaries of chick, mouse or zebrafish embryos [26-30]. Little is known regarding the function of these factors at rhombomere interfaces. Interestingly, before boundary cells are formed, several of these signals, such as FGF3 and follistatin, have segmental expression within specific rhombomeres. The significance of these dynamic spatio-temporal expression patterns as well as the regulatory mechanisms by which these signals are turned on and off in different hindbrain regions are not clear."

Links: Chicken Development

Original file name: Figure 3. The boundary cell marker FGF3 shows persistent segmental expression in embryos expressing truncated EphA4. 1471-213X-9-16-3.jpg (image extracted from full figure, resized and labeled)

Reference

<pubmed>19232109</pubmed>| PMC2656489 | BMC Dev Biol.

© 2009 Sela-Donenfeld et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.