Developmental Mechanism - Epithelial Mesenchymal Interaction
|Embryology - 23 May 2019 Expand to Translate|
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Epithelial cells (organised cellular layer) and mesenchymal cells (disorganised cellular layers) or embryonic connective tissue interact together signaling back and forth by secreted signals or contact in the differentiation of many different organs, tissues and structures.
Cells organised as a layer (epithelia) and cells organised as a multilayer embryonic connective tissue (mesenchymal) signaling back and forth are key to the of development in many different tissues. For example, in nephron development in the kidney, hair development on the skin and tooth development in the oral epithelium.
In both hair and tooth, an initial epithelial placed is initially formed, that then invaginates into the underlying mesenchyme, and signals for this mesenchyme to then develop.
Some Recent Findings
Uterine Gland Development
Uterine adenogenesis is the term used to describe the formation of uterine glands from the epithelial lining of the uterus. In mammals, this development occurs postnatally and has been described as occurring through a 3 step the sequence:
- differentiation and budding of the glandular epithelium.
- invagination and tubular coiling of the epithelium.
- branching of the glandular elements and their expansion throughout the endometrial stroma toward the myometrium.
Epithelial-mesenchymal interaction occurs through Wnt signalling during this process:
- Wnt7a - expressed in the luminal epithelium
- Wnt5a - expressed in the mesenchyme
- Shelton DN, Fornalik H, Neff T, Park SY, Bender D, et al. (2012) The Role of LEF1 in Endometrial Gland Formation and Carcinogenesis. PLoS ONE 7(7): e40312. doi:10.1371/journal.pone.0040312
Search Pubmed: Epithelial Mesenchymal Interaction
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Cite this page: Hill, M.A. (2019, May 23) Embryology Developmental Mechanism - Epithelial Mesenchymal Interaction. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Mesenchymal_Interaction
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G