Developmental Mechanism - Epithelial Mesenchymal Interaction
|Embryology - 3 Jun 2020 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
Epithelial cells (organised cellular layer) and mesenchymal cells (disorganised cellular layers) or embryonic connective tissue interact together signaling back and forth by secreted signals or contact in the differentiation of many different organs, tissues and structures.
Cells organised as a layer (epithelia) and cells organised as a multilayer embryonic connective tissue (mesenchymal) signaling back and forth are key to the of development in many different tissues. For example, in nephron development in the kidney, hair development on the skin and tooth development in the oral epithelium.
In both hair and tooth, an initial epithelial placed is initially formed, that then invaginates into the underlying mesenchyme, and signals for this mesenchyme to then develop.
Some Recent Findings
Uterine Gland Development
Uterine adenogenesis is the term used to describe the formation of uterine glands from the epithelial lining of the uterus. In mammals, this development occurs postnatally and has been described as occurring through a 3 step the sequence:
- differentiation and budding of the glandular epithelium.
- invagination and tubular coiling of the epithelium.
- branching of the glandular elements and their expansion throughout the endometrial stroma toward the myometrium.
Epithelial-mesenchymal interaction occurs through Wnt signalling during this process:
- Wnt7a - expressed in the luminal epithelium
- Wnt5a - expressed in the mesenchyme
- Shelton DN, Fornalik H, Neff T, Park SY, Bender D, et al. (2012) The Role of LEF1 in Endometrial Gland Formation and Carcinogenesis. PLoS ONE 7(7): e40312. doi:10.1371/journal.pone.0040312
Search Pubmed: Epithelial Mesenchymal Interaction
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2020, June 3) Embryology Developmental Mechanism - Epithelial Mesenchymal Interaction. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Mesenchymal_Interaction
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G