Adipose Tissue Development
|Embryology - 22 Apr 2019 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Development Overview
- 4 Molecular Development
- 5 White Adipose
- 6 Brown Adipose
- 7 Beige Adipose
- 8 Somite - Dermatome
- 9 Somatic Mesoderm
- 10 Splanchnic Mesoderm
- 11 References
- 12 Additional Images
- 13 Terms
- 14 Glossary Links
Draft Page - notice removed when completed.
Connective tissues in the body have a mesoderm origin, while in the head neural crest also contributes to these tissues.
Blood is a liquid connective tissue (More? blood).
- Loose and dense connective tissue
- Reticular connective tissue
- Adipose Tissue
- Mesenchymal connective tissue
Postnatally, a third form of "beige adipose tissue" has been identified in teh mouse model. This form of adipose can be induced in subcutaneous white adipose tissue as a response to cold and other thermogenic activators.
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|Anatomical Region||Specific Location||Start
|Table Notes - weeks are fertilization age (FA), not GA, both male and female data are combined.|
- hand - begins in the subcutis of the palm and then progresses proximally to the wrist and distally into the fingers.
- week 23 - thickened layer of subcutaneous fat covers the extremities of the limbs, as for newborn.
Adipocyte differentiation regulation.
- Links: NOTCH
- Brown Adipose Tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle,
- Brown adipocytes have numerous small lipid droplets rather than a single large one as in white adipocytes
- Elevated numbers of mitochondria
- mitochondrial expression of the nuclear gene UCP1, the uncoupler of oxidative phosphorylation responsible for non-shivering thermogenesis.
BAT distribution in the newborn infant:
- Interscapular - mass lies in a thin diamond-shaped sheet between the shoulder blades, separated from the subcutaneous WAT by a discontinuous fibrous layer. When replete with fat it has a yellowish-brown colour; depleted it is much darker. It has a fine lobular structure.
- Neck muscles and blood vessels - many smaller masses with the main mass following the course of the internal jugular vein and common carotid artery.
- Axilla - large deposits as extensions from the neck tissue that pass under the clavicles.
- Great vessels - entering the thoracic inlet extending as fine fingers that spread out from the midline with each intercostal artery. Similar deposits lie among the internal mammary vessels. Many discrete, moderately large masses lie in the mediastinum between the oesophagus and the trachea.
- Abdomen - discrete masses accompany the aorta and lie in relation to many structures on the posterior abdominal wall such as the pancreas, autonomic ganglia and chromaffin tissue. The largest abdominal mass envelops the [[renal}} and adrenals.
A third form of "beige adipose tissue" has been identified in the mouse model. This form of adipose can be induced in subcutaneous white adipose tissue as a response to cold and other thermogenic activators. This conversion process has also been described as "browning".
Somite - Dermatome
The dermis and hypodermis layers of the skin.
The body wall connective tissue.
The lamina propria and submucosa layers of the gastrointestinal tract wall.
- Chan M, Lim YC, Yang J, Namwanje M, Liu L & Qiang L. (2019). Identification of a natural beige adipose depot in mice. J. Biol. Chem. , , . PMID: 30824545 DOI.
- Tanimura K, Suzuki T, Vargas D, Shibata H & Inagaki T. (2019). Epigenetic regulation of beige adipocyte fate by histone methylation. Endocr. J. , 66, 115-125. PMID: 30606913 DOI.
- Sebo ZL, Jeffery E, Holtrup B & Rodeheffer MS. (2018). A mesodermal fate map for adipose tissue. Development , , . PMID: 30045918 DOI.
- Stephens JM. (2012). The fat controller: adipocyte development. PLoS Biol. , 10, e1001436. PMID: 23209380 DOI.
- Cannon B & Nedergaard J. (2004). Brown adipose tissue: function and physiological significance. Physiol. Rev. , 84, 277-359. PMID: 14715917 DOI.
- Poissonnet CM, LaVelle M & Burdi AR. (1988). Growth and development of adipose tissue. J. Pediatr. , 113, 1-9. PMID: 3290412
- Shan T, Liu J, Wu W, Xu Z & Wang Y. (2017). Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes. J. Cell. Physiol. , 232, 1258-1261. PMID: 27869309 DOI.
- Aherne W & Hull D. (1966). Brown adipose tissue and heat production in the newborn infant. J Pathol Bacteriol , 91, 223-34. PMID: 5941392 DOI.
Billon N, Kolde R, Reimand J, Monteiro MC, Kull M, Peterson H, Tretyakov K, Adler P, Wdziekonski B, Vilo J & Dani C. (2010). Comprehensive transcriptome analysis of mouse embryonic stem cell adipogenesis unravels new processes of adipocyte development. Genome Biol. , 11, R80. PMID: 20678241 DOI.
Billon N, Iannarelli P, Monteiro MC, Glavieux-Pardanaud C, Richardson WD, Kessaris N, Dani C & Dupin E. (2007). The generation of adipocytes by the neural crest. Development , 134, 2283-92. PMID: 17507398 DOI.
Search Pubmed: adipose Development
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Cite this page: Hill, M.A. (2019, April 22) Embryology Adipose Tissue Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Adipose_Tissue_Development
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G