Abnormal Development - Listeria
|Embryology - 25 May 2019 Expand to Translate|
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The bacterium Listeria monocytogenes is the pathogenic form of the 7 listeria species. Infection is generally through ingestion of organisms in contaminated food. Maternal symptoms may be mild, fetal effects can range from insignificant through to major abnormalities. Maternal treatment relates to potential developmental effects. Pregnancy greatly increases the risk of listeriosis, with pregnant women about 60% of all cases (male and female) aged 10 to 40 years. Similar effects are seem in other mammalian species. See also the listeriosis review article and the Guinea pig placenta listeria model Generalized suppression of immunity during pregnancy is suggest to have a role in susceptibility, though recent results in a mouse model suggest that susceptibility can occur very early in a pregnancy and may relate to enteric carriage rate.
|Bacterial Links: bacterial infection | syphilis | gonorrhea | tuberculosis | listeria | salmonella | TORCH | Environmental | Category:Bacteria|
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
<pubmed limit=5>Listeria Pregnancy</pubmed>
- ingestion of contaminated food
- colonization of the intestine
- intestinal translocation
- replication in the liver and spleen
- either the resolution of infection or spread to other organs resulting in a systemic infection
Model of L. monocytogenes mechanisms for breaching the maternal-fetal barrier (text below modified from original reference)
Bacterial staining procedure named after Hans Christian Gram (1853 - 1938). Generally divides bacteria into either:
- Gram-positive bacteria purple crystal violet stain is trapped by layer of peptidoglycan (forms outer layer of the cell).
- Gram-negative bacteria outer membrane prevents stain from reaching peptidoglycan layer in the periplasm, outer membrane then permeabilized and pink safranin counterstain is trapped by peptidoglycan layer.
- Links: Histology Stains
Australian NHMRC Recommendations
The Australian NHMRC (1988) recommends neonates be assessed for follow-up care under the following conditions.
- Birthweight less than 1500g or gestational age less than 32 weeks
- Small-for-gestational-age neonates
- Perinatal asphyxia
- Apgar score less than 3 at 5 minutes
- clinical evidence of neurological dysfunction
- delay in onset of spontaneous respiration for more than 5 minutes and requiring mechanical ventilation
- Clinical evidence of central nervous system abnormalities ie., seizures, hypotonia
- Hyperbilirubinaemia of greater than 350umol/l in full term neonates
- Genetic, dysmorphic or metabolic disorders or a family history of serious genetic disorder
- Perinatal or serious neonatal infection including children of mothers who are HIV positive
- Psychosocial problems eg., infants of drug-addicted or alcoholic mothers.
- Links: NHMRC WWW Page
- Suyemoto MM, Spears PA, Hamrick TS, Barnes JA, Havell EA & Orndorff PE. (2010). Factors associated with the acquisition and severity of gestational listeriosis. PLoS ONE , 5, e13000. PMID: 20885996 DOI.
- Doganay M. (2003). Listeriosis: clinical presentation. FEMS Immunol. Med. Microbiol. , 35, 173-5. PMID: 12648833
- Bakardjiev AI, Stacy BA & Portnoy DA. (2005). Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection. J. Infect. Dis. , 191, 1889-97. PMID: 15871123 DOI.
- Chan LM, Lin HH & Hsiao SM. (2018). Successful treatment of maternal listeria monocytogenes bacteremia in the first trimester of pregnancy: A case report and literature review. Taiwan J Obstet Gynecol , 57, 462-463. PMID: 29880186 DOI.
- Simon K, Simon V, Rosenzweig R, Barroso R & Gillmor-Kahn M. (2018). Listeria, Then and Now: A Call to Reevaluate Patient Teaching Based on Analysis of US Federal Databases, 1998-2016. J Midwifery Womens Health , 63, 301-308. PMID: 29799155 DOI.
- <pubmed>20107601</pubmed>| PLoS
Lamont RF, Sobel J, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Kim SK, Uldbjerg N & Romero R. (2011). Listeriosis in human pregnancy: a systematic review. J Perinat Med , 39, 227-36. PMID: 21517700 DOI.
Goldenberg RL & Thompson C. (2003). The infectious origins of stillbirth. Am. J. Obstet. Gynecol. , 189, 861-73. PMID: 14526331
Albritton WL, Cochi SL & Feeley JC. (1984). Overview of neonatal listeriosis. Clin Invest Med , 7, 311-4. PMID: 6398177
Bakardjiev AI, Stacy BA, Fisher SJ & Portnoy DA. (2004). Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect. Immun. , 72, 489-97. PMID: 14688130
Topalovski M, Yang SS & Boonpasat Y. (1993). Listeriosis of the placenta: clinicopathologic study of seven cases. Am. J. Obstet. Gynecol. , 169, 616-20. PMID: 8372871
Storrs CN & Partridge JW. (1980). Listeria infections in the newborn. Arch. Dis. Child. , 55, 246. PMID: 7387172
Luft BJ & Remington JS. (1982). Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice. Infect. Immun. , 38, 1164-71. PMID: 6818146
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- NHMRC (Australia) - Prevention of Listeria (PDF)
- Medline Plus
- Royal College of Obstetricians and Gynaecologists (UK) Infection and Pregnancy - study group recommendations (Jun 2001)
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Cite this page: Hill, M.A. (2019, May 25) Embryology Abnormal Development - Listeria. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Listeria
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G