User:Z3290689
Lab 4 Online Assessment
- The allantois, identified in the placental cord, is continuous with what anatomical structure?
- Identify the 3 vascular shunts, and their location, in the embryonic circulation.
- Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)
--Z3290689 12:58, 28 July 2011 (EST)
Lab Attendance: (from week 3)
--z3290689 11:33, 11 August 2011 (EST)
--Mark Hill 09:55, 3 August 2011 (EST) Where are your Lab 1 assessment answers? Need to added before Lab 2.
Laboratory Session 1 Assessment Answers:
1). Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.
The first successful use of In vitro fertilization (hereafter IVF) as an assisted reproductive technology occurred in 1978 under the direction of Robert D. Edwards, et al with the birth of Louise Brown. In 2010, Robert D. Edwards received the Nobel Prize in Physiology or Medicine "for the development of in vitro fertilization."
2. Identify a recent paper on fertilisation and describe its key findings.
Eskander R.N., Randall L.M., Berman M.L., Tewari K.S., Disaia P.J., Bristow R.E. (2011). Fertility preserving options in patients with gynecologic malignancies. American Journal of Obstetrics & Gynecology, doi: 10.1016/j.ajog.2011.01.025
The key findings of this paper were that given the rising median age of primiparous women - when correlated with the median age of diagnosis of cervical, endometrial and ovarian cancer - exhibited a trend whereby a higher portion of nulliparous women would be diagnosed with conditions which could potentially severely reduce fertility. Consequently, there is increased pressure on obstetricians to offer non-standard treatments with higher risks to patients wishing to retain the option to bear children.
3. Identify 2 congenital anomalies. Neurofibromatosis and cystic fibrosis. Neurofibromatosis is a condition presenting with diffuse tumour growth in nervous tissue, often presenting superficially with raised welts. Cystic Fibrosis is a disease in which electrolyte balance, regulation and transport is compromised due to the absence of a certain protein. Signs and symptoms are numerous and varied.
--z3290689 12:34, 4 August 2011 (EST)
Laboratory Session 2 Assessment Answers:
1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.
ZP3 and ZP4 are the first proteins to bind to sperm, inducing the acrosome reaction. After induction of the acrosome reaction, ZP2 binds spermatozoa and is cleaved, causing conformational change of ZP3 that prevents polyspermy.
2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)
Congenital Hypomyelinating Neuropathy:
Feltri M.A., et al (2000). P0 Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves. The Journal of Cell Biology 148(5), 1021-1034
This article addresses the role of the Myelin protein zero gene in regulating the levels of P0 protein, and the resulting degrees of either hypo- or hyper-myelination.
--z3290689 21:14, 7 August 2011 (EST)
Lab 3:
1). What is the maternal dietary requirement for late neural development?
Iodine.
File:Differentially expressed RefSeq genes in human trisomy 21
