User:Z3290270

Lab 4 Online Assessment

The allantois, identified in the placental cord, is continuous with what anatomical structure?
Identify the 3 vascular shunts, and their location, in the embryonic circulation.
Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)

Lab attendence:

--Z3290270 12:56, 28 July 2011 (EST)

--Maeda Sadeghpour 11:48, 4 August 2011 (EST)

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique. The history of IVF dates back to early as 1890s with physicians conducting experiemnts on animal embryo transplantation. With increased research into egg maturation cycle and optimal conditions of fertilization in the womb, the first IVF animal was born in 1959. Robert Edwards was awarded The Nobel Prize in Physiology or Medicine 2010 for the "for the development of in vitro fertilization".

2. Identify a recent paper on fertilisation and describe its key findings.

Carson C, Kelly Y, Kurinczuk J, Sacker A, Redshaw M, Quigley M. (2011). Effect of pregnancy planning and fertility treatment on cognitive outcomes in children at ages 3 and 5: longitudinal cohort study. BMJ, 343(d4473). The UK based cohort study recorded cognitive outcomes in children born after planned and unplanned pregnancy. The study found that there is no evidence that pregnancy planning, subfertility, or assisted fertility had a direct affect on the subject’s cognitive development at age 3 or 5. Children conceived through unplanned pregnancies score poorly in comparison to those born as a result of planned pregnancy but this was linked to socioeconomic factors and inequalities.

3. Identify 2 congenital anomalies.

Hirschsprung’s disease, Spina bifida

--Mark Hill 09:49, 3 August 2011 (EST) These answers are fine, you seem to be able to work online for this course. I will also be showing you how the reference can be linked to the internet database.

Lab 2- Assignment:Link title

1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.

ZP3 – Zona pellucida glycoprotein 3, which acts as a receptor for spermatozoa. ZP3 stimulates the acrosome reaction, allowing enzymes to be released from the acrosome of the sperm which subsequently digest a path through the zona pellucida. This causes intracellular calcium levels in the oocyte to increase, causing the activation of cortical granules. An enzyme of the cortical granules clips the terminal sugar residues of ZP3 carbohydrate chains which makes the egg impenetrable by another sperm.

2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)

Review: Padmanabhan, R. (2006). Etiology, pathogenesis and prevention of neural tube defects. Congenital Anomalies, 46(2), 55-67.

Research: Joó, J. G., Beke, A., Papp, C., Tóth-Pál, E., Csaba, A., Szigeti, Z., Papp, Z. (2007). Neural tube defects in the sample of genetic counselling. Prenatal Diagnosis, 27(10), 912-21.