Talk:Placenta - Cord: Difference between revisions
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Cite this page: Hill, M.A. (2024, May 4) Embryology Placenta - Cord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Placenta_-_Cord |
Placental Cord
<pubmed limit=5>Placental+Cord</pubmed>
Cord Coiling
<pubmed limit=5>Cord+Coiling</pubmed>
Cord Vessel Number
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2014
2013
2011
Persistent right umbilical vein: a prenatal condition worth mentioning?
Ultrasound Obstet Gynecol. 2011 May;37(5):543-8. doi: 10.1002/uog.7764. Epub 2011 Mar 25.
Weichert J, Hartge D, Germer U, Axt-Fliedner R, Gembruch U. Source Division of Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Luebeck, Germany. jan.weichert@uk-sh.de
Abstract
OBJECTIVES: To investigate the incidence and clinical impact of prenatally diagnosed persistent right umbilical vein (PRUV) in a referral population and to evaluate the findings together with those from previous publications. METHODS: This was a retrospective analysis of 39 cases with PRUV diagnosed in three tertiary referral centers for prenatal medicine between 1996 and 2009. Fetuses with situs inversus, situs ambiguous and heterotaxy (left and right isomerism) were excluded. During the study period 46 653 consecutive high- and low-risk pregnancies were examined. The prenatal sonograms and neonatal outcome data of affected individuals were reviewed. Our findings were analyzed together with findings retrieved from the scientific literature. RESULTS: Twenty-nine fetuses had an isolated PRUV as a single anomaly, whereas 10/39 (25.6%) were found to have PRUV accompanied by additional minor and major abnormalities. These anomalies comprised mainly cardiovascular, genitourinary and gastrointestinal malformations. In common with our series, previously published cases of isolated PRUV (n = 197) displayed an uneventful course of pregnancy and a favorable postnatal outcome. Sixty-six previously reported cases of PRUV with additional anomalies were identified in the literature. Intrahepatic umbilical drainage is the most frequent type of PRUV. Including our cases, there were 16 cases (5.3%) with extrahepatic drainage of PRUV, all of which had additional anomalies. CONCLUSIONS: Consistent with previous reports, in the majority of cases (74.8%) PRUV is an isolated finding. While these cases carry an excellent prognosis, PRUV can be associated with severe congenital anomalies, so this finding should prompt detailed prenatal assessment of the fetus. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
PMID 20922781
Area of Wharton's jelly as an estimate of the thickness of the umbilical cord and its relationship with estimated fetal weight
Reprod Health. 2011 Nov 4;8:32.
Barbieri C, Cecatti JG, Surita FG, Costa ML, Marussi EF, Costa JV. Source Department of Obstetrics and Gynecology, School of Medical Sciences, Universidade Estadual de Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Abstract
BACKGROUND: To build a reference curve for the area of Wharton's jelly (WJ) in low-risk pregnancies from 13 to 40 weeks and to assess its relationship with estimated fetal weight (EFW). METHODS: 2,189 low-risk pregnancies had the area of WJ estimated by ultrasound and the 10th, 50th and 90th percentiles calculated using a third-degree polynomial regression procedure. EFW by ultrasound was correlated with the measurement of the area of WJ. RESULTS: The area of WJ increased according to gestational age (R² = 0.64), stabilizing from the 32nd week onwards. There was a significant linear correlation between area of WJ and EFW up to 26 weeks (R = 0.782) and after that 5t remained practically constant (R = 0.047). CONCLUSION: The area of WJ increases according to gestational age, with a trend to stabilize at around 32 weeks of gestation. It is also linearly correlated with EFW only up to 26 weeks of gestation.
PMID 22054163
http://www.reproductive-health-journal.com/content/8/1/32
2008
Quantitative analysis of the microstructure of human umbilical vein for assessing feasibility as vessel substitute
Ann Vasc Surg. 2008 May-Jun;22(3):417-24. doi: 10.1016/j.avsg.2007.12.021.
Li WC, Zhang HM, Wang PJ, Xi GM, Wang HQ, Chen Y, Deng ZH, Zhang ZH, Huang TZ. Source Institute of Basic Medical Sciences, Yunyang Medical College, Shiyan, People's Republic of China. wenchunli01@163.com
Abstract
We explored the feasibility of human umbilical vein (HUV) as a small-caliber vessel substitute. HUVs of 50 fetuses were collected on spontaneous miscarriage or labor with the pregnant women's permission. Gestational age ranged 24-42 weeks, and parturients were 20-30 years old. Each sample was sliced into 5 mum frozen transverse sections and stained with hematoxylin-eosin (HE), Weigert, aniline blue, and orange yellow G. The geometric morphological indexes and microstructural component were measured by a computer image analysis system. The media thickness was 0.186, 0.203, 0.237, 0.264, and 0.268 mm at 24-27, 28-32, 33-36, 37-40, and 41-42 weeks, respectively (F = 133.35, p < 0.01); diameters were 1.861, 1.962, 2.303, 2.464, and 2.465 mm (F = 37.35, p < 0.01), respectively. The media thickness and diameter of HUVs increased with gestational age. The elastin content of media increased at 24-40 weeks, but the collagen content and collagen/elastin (C/E) ratio decreased. Elastin content in the proximal segment was higher than in the distal segment [10.16, 6.36 Aa%, (Aa% is the unit of relative content, ie, the ratio of absolute areas to the total tested area of smooth muscle, collagen and elastin in the vascular wall) F = 5.77-12.3, p < 0.05], with the collagen to elastin (C/E) ratio increasing from the proximal to the distal segment (F = 7.63-13.4, p < 0.05). Our results suggest that the microstructural component of HUVs (2.0-3.0 mm caliber) at 37-40 weeks of gestation was similar to that of the small-caliber arteries and had moderate amounts of collagen and elastin and good elasticity, i.e., a good C/E ratio; therefore, HUV may be a substitute for small-caliber arteries (e.g., brachial, ulnar, radial, right coronary, anterior tibial, and posterior tibial). HUV is one of several graft materials that may be used when autogenous saphenous vein is absent or inadequate. PMID 18466819
2007
Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis
Seval Y, Korgun ET, Demir R. Placenta. 2007 Aug-Sep;28(8-9):841-5. Epub 2007 Mar 9.
The stroma of the placental villi contain numerous macrophages, so-called Hofbauer cells which are of mesenchymal origin and are thought to function in many processes. Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes. In this study we hypothesized that Hofbauer cell locations and numbers might be correlated with the vascular structures within the placental villi core and therefore may be implicated to play roles in placental vasculogenesis and angiogenesis. Placental tissues were obtained from normal first-trimester pregnancies. Tissues were prepared for light microscopic investigations. Double immunohistochemistry staining with CD31/PECAM1 and CD68 was applied to placental tissues. In placental villous core, majority of the Hofbauer cells were found to be either in close contact with angiogenic cell cords and primitive vascular tubes or located in between them. Moreover, the number of Hofbauer cells and vasculogenic structures were found to be significantly correlated. The findings of this study suggest for the first time that Hofbauer cells might be involved in the processes of vasculogenesis and angiogenesis in the placenta.
PMID 17350092
2006
The umbilical coiling index and adverse perinatal outcome
Int J Gynaecol Obstet. 2006 Oct;95(1):8-13. Epub 2006 Jul 24.
Kashanian M, Akbarian A, Kouhpayehzadeh J. Source Iran University of Medical Sciences, Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Tehran, Iran. maryamkashanian@yahoo.com <maryamkashanian@yahoo.com>
Abstract OBJECTIVE: Evaluation of the relationship between umbilical coiling index (UCI) and adverse perinatal outcome. METHOD: A prospective study was performed on 699 pregnant women who were 37-40 weeks. UCI was determined by dividing the total number of the complete vascular coiling by the total umbilical cord length in centimeters. Then the relationship between UCI and neonatal weight, amniotic fluid index, meconium, Apgar score, and fetal distress were evaluated. RESULTS: There was a significant difference between normo- and hypocoiled groups according to the Apgar score less than 7 in minute 5, AFI<or=5; and between normo- and hypercoiled groups according to Apgar score less than 7 in minute 5, AFI<or=5, meconium, and fetal distress. Neonatal weight in normocoiled was higher than hypercoiled group. AFI<or=5, meconium and fetal distress were higher in hypercoiled than hypocoiled group. Neonatal weight in hypercoiled was less than that in the hypocoiled group, respectively. CONCLUSION: Abnormal UCI may relate to adverse perinatal outcome. PMID 16860802
2005
Embryogenesis of fused umbilical arteries in human embryos
Am J Obstet Gynecol. 2005 Nov;193(5):1709-15.
Yamada S, Hamanishi J, Tanada S, Tachibana M, Mimura R, Fujii S, Shiota K. Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan. shyamada@cac.med.kyoto-u.ac.jp
Abstract
OBJECTIVE: The objective of this study was to elucidate the embryologic basis of fused umbilical arteries in the human.
STUDY DESIGN: Twenty-nine human embryo specimens at Carnegie stages 11 through 15 (4-5 weeks after fertilization) were examined histologically, with special reference to the development of umbilical arteries.
RESULTS: All embryos at Carnegie stage 11 and 12 had fused umbilical arteries, and 66% of Carnegie stage 13 embryos and 29% of Carnegie stage 14 embryos still had the condition. None of the embryos at Carnegie stage 15 or older had fused umbilical arteries, but there were always 2 arteries present in their umbilical cords. CONCLUSION: Our data suggest that (1) a single umbilical artery splits into 2 as the developmental stage of the embryo advances, (2) that fused umbilical arteries represent a remnant of the embryonic phenotype, and (3) that fused umbilical arteries are embryologically distinct from true single umbilical artery.
PMID 16260215
2001
Pediatr Dev Pathol. 2001 Mar-Apr;4(2):144-53. Morbidity, mortality, and placental pathology in excessively long umbilical cords: retrospective study. Baergen RN, Malicki D, Behling C, Benirschke K. Source Department of Pathology, New York Presbyterian Hospital-Weill Medical College of Cornell University, NY 10021, USA.
Abstract
The purpose of this study was to compare specific fetal, maternal, and placental factors, including neonatal morbidity and mortality, in infants with umbilical cords (UCs) of normal length to the same factors in infants with excessively long umbilical cords (ELUCs). We performed an 18-year retrospective chart review of the medical records of mothers and infants with ELUCs (926 cases) and normal-length UCs (200 cases) and recorded maternal factors, fetal factors, and neonatal outcomes. Corresponding placental pathologic reports and slides were reviewed. Statistical analysis comparing the two groups included univariate and multivariate analyses. ELUCs were significantly associated with certain maternal factors (systemic diseases, delivery complications, increased maternal age), fetal factors (non-reassuring fetal status, respiratory distress, vertex presentation, cord entanglement, fetal anomalies, male sex, increased birth weight), gross placental features (increased placental weight, right-twisted cords, markedly twisted cords, true knots, congestion), and microscopic placental features (nucleated red blood cells, chorangiosis, vascular thrombi, vascular cushions, meconium, increased syncytial knots, single umbilical artery). Some of these histopathologic features have previously been associated with fetal hypoxia and/or altered blood flow in the placenta. Infants with ELUCs were found to be at a significantly increased risk of brain imaging abnormalities and/or abnormal neurological follow-up. In addition, mothers with a history of an ELUC are at increased risk of a second long cord.
PMID 11178630
1989
Isolation and characterization of Hofbauer cells from human placental villi
Arch Gynecol Obstet. 1989;246(4):189-200.
Zaccheo D, Pistoia V, Castellucci M, Martinoli C.
Istituto di Anatomia Umana Normale, Università di Genova, Italy. Abstract Hofbauer cells are a major cell type of the human placental villous core and they are particularly numerous at the beginning of pregnancy. In the present study we describe a method suitable to obtain HC suspensions in a highly purified form. These suspensions have been analyzed for surface markers using a battery of monoclonal antibodies. Of all the surface markers used, Hofbauer cells were only positive for 4F2, LeuM2 and LeuM3 monoclonals which mainly detect cells of the monocyte-macrophage lineage. Hofbauer cells were consistently negative for HLA-DR antigens, C3bR and T- or B-cell markers. Hofbauer cells appeared capable of phagocytosing latex beads, adhering to and spreading over plastic surface and secreting lysozyme. In contrast, they failed to originate an efficient respiratory burst in response to appropriate stimulation. Hofbauer cells were positive for ANAE with a perinuclear localization of the enzyme activity, but consistently negative for peroxidase. These observations suggest that they share a number of features with cells of the monocyte-macrophage lineage and yet have some distinctive properties.
PMID 2482706
