Talk:Joint Development - Temporomandibular Joint
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Cite this page: Hill, M.A. (2024, May 26) Embryology Joint Development - Temporomandibular Joint. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Joint_Development_-_Temporomandibular_Joint |
2015
Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice
Mol Med Rep. 2015 Jun 18. doi: 10.3892/mmr.2015.3959. [Epub ahead of print]
Li X1, Liang W2, Ye H1, Weng X3, Liu F1, Lin P3, Liu X1.
Abstract
The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. The results showed that the developmental process and expression levels of runt-related transcription factor 2 and sex determining region Y-box 9 in the TMJ of the Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice were similar to those in wild‑type mice. Overexpression of Ihh rescued shox2 overexpression-associated reduction of extracellular matrix components. However, overexpression of Ihh did not inhibit the shox2 overexpression-associated increase of matrix metalloproteinases (MMPs) MMP9, MMP13 and apoptosis in the TMJ. These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice.
PMID 26096903
2014
Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development
Anat Res Int. 2014;2014:732720. doi: 10.1155/2014/732720. Epub 2014 Jan 12.
Alvez CS1, Carvalho de Moraes LO2, Marques SR2, Tedesco RC2, Harb LJ3, Rodríguez-Vázquez JF4, Mérida-Velasco JR4, Alonso LG2.
Abstract
Objective. To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial.
PMID 24527214
