Talk:Genital - Female Development

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent | Reference Tutorial | Journal Searches Glossary Links Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link Cite this page: Hill, M.A. (2024, May 20) Embryology Genital - Female Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Genital_-_Female_Development

2014

Combined laparoscopy and hysteroscopy for the detection of female genital system anomalies results of 3,811 infertile women

J Reprod Med. 2014 Nov-Dec;59(11-12):542-6.

Siam S1, Soliman BS.

Abstract

OBJECTIVE: To assess the prevalence of Mullerian and gonadal anomalies in a group of infertile women using a combination of diagnostic laparoscopy and hysteroscopy. STUDY DESIGN: This was a retrospective descriptive study in the setting of a university hospital. The records of 3,811 women who underwent laparoscopy and hysteroscopy for infertility were reviewed. RESULTS: Mullerian duct anomalies (MDAs) were diagnosed in 287/3,811 (7.5%) women, gonadal anomalies in 40/3,811 (1.04%) women, MDAs and gonadal anomalies in 22/3,811 (0.57%) women, and "undefined anomalies" in 8/3,811 (0.2%) women. Among the 287 women with MDAs 54.9% were diagnosed with a septate uterus, 14.2% with an arcuate uterus, 10.2% with a bicornuate uterus, 5.8% with a unicornuate uterus, 4.7% with tubal anomalies, 3.6% with a hypoplastic uterus, 2.9% with Mullerian agenesis, 1.8% with a septate uterus and a double cervix, 1.1% with uterus didelphys, and 0.7% with a longitudinal vaginal septum. Among the 40 women with gonadal anomalies 70% were diagnosed with hypoplastic ovaries, 25% with streak gonads, and 5% with an accessory ovary. Among the 22 women with combined Mullerian and gonadal anomalies 50% were diagnosed with streak gonads and a hypoplastic uterus, 31.8% with a hypoplastic uterus and hypoplastic ovaries, and 18.2% with ovarian and tubal anomalies. CONCLUSION: Combined laparoscopy and hysteroscopy are valuable tools for the diagnosis and classification of female genital system anomalies. PMID 25552125

FOXL2 is a female sex-determining gene in the goat

Curr Biol. 2014 Feb 17;24(4):404-8. doi: 10.1016/j.cub.2013.12.039. Epub 2014 Jan 30.

Boulanger L1, Pannetier M1, Gall L1, Allais-Bonnet A1, Elzaiat M1, Le Bourhis D2, Daniel N1, Richard C1, Cotinot C1, Ghyselinck NB3, Pailhoux E4.

Abstract

The origin of sex reversal in XX goats homozygous for the polled intersex syndrome (PIS) mutation was unclear because of the complexity of the mutation that affects the transcription of both FOXL2 and several long noncoding RNAs (lncRNAs). Accumulating evidence suggested that FOXL2 could be the sole gene of the PIS locus responsible for XX sex reversal, the lncRNAs being involved in transcriptional regulation of FOXL2. In this study, using zinc-finger nuclease-directed mutagenesis, we generated several fetuses, of which one XX individual bears biallelic mutations of FOXL2. Our analysis demonstrates that FOXL2 loss of function dissociated from loss of lncRNA expression is sufficient to cause an XX female-to-male sex reversal in the goat model and, as in the mouse model, an agenesis of eyelids. Both developmental defects were reproduced in two newborn animals cloned from the XX FOXL2(-/-) fibroblasts. These results therefore identify FOXL2 as a bona fide female sex-determining gene in the goat. They also highlight a stage-dependent role of FOXL2 in the ovary, different between goats and mice, being important for fetal development in the former but for postnatal maintenance in the latter. Copyright © 2014 Elsevier Ltd. All rights reserved.

PMID 24485832

2003

Development of the human Müllerian duct in the sexually undifferentiated stage

Anat Rec A Discov Mol Cell Evol Biol. 2003 Jun;272(2):514-9.

Hashimoto R1.

Abstract

An embryological explanation for the development of the Müllerian duct still poses a major challenge. The development of this duct was investigated systematically in human embryos. Seven embryos (Carnegie stages 18-23) were serially sectioned in the frontal, sagittal, and transversal planes at a thickness of 10 microm and stained with hematoxylin and eosin (H&E) for histological analysis. In all observed embryos, the caudal end of the Müllerian duct was found to be intimately connected to the Wolffian duct. The opening of the Müllerian duct to the coelomic cavity was formed as the result of an invagination of the coelomic epithelium at Carnegie stage 18. The duct grew independently from the invagination during stages 19-23. The fused duct (uterovaginal canal) bifurcated at the caudal portion at Carnegie stages 22 and 23. This is the first description of the caudal portion of the fused Müllerian ducts separating again and returning to each of the Wolffian ducts in human embryos. Copyright 2003 Wiley-Liss, Inc.

PMID: 12740945