Talk:Genital - Female Development: Difference between revisions
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==2015== | |||
==2014== | ==2014== | ||
===Combined laparoscopy and hysteroscopy for the detection of female genital system anomalies results of 3,811 infertile women=== | |||
J Reprod Med. 2014 Nov-Dec;59(11-12):542-6. | |||
Siam S1, Soliman BS. | |||
Abstract | |||
OBJECTIVE: | |||
To assess the prevalence of Mullerian and gonadal anomalies in a group of infertile women using a combination of diagnostic laparoscopy and hysteroscopy. | |||
STUDY DESIGN: | |||
This was a retrospective descriptive study in the setting of a university hospital. The records of 3,811 women who underwent laparoscopy and hysteroscopy for infertility were reviewed. | |||
RESULTS: | |||
Mullerian duct anomalies (MDAs) were diagnosed in 287/3,811 (7.5%) women, gonadal anomalies in 40/3,811 (1.04%) women, MDAs and gonadal anomalies in 22/3,811 (0.57%) women, and "undefined anomalies" in 8/3,811 (0.2%) women. Among the 287 women with MDAs 54.9% were diagnosed with a septate uterus, 14.2% with an arcuate uterus, 10.2% with a bicornuate uterus, 5.8% with a unicornuate uterus, 4.7% with tubal anomalies, 3.6% with a hypoplastic uterus, 2.9% with Mullerian agenesis, 1.8% with a septate uterus and a double cervix, 1.1% with uterus didelphys, and 0.7% with a longitudinal vaginal septum. Among the 40 women with gonadal anomalies 70% were diagnosed with hypoplastic ovaries, 25% with streak gonads, and 5% with an accessory ovary. Among the 22 women with combined Mullerian and gonadal anomalies 50% were diagnosed with streak gonads and a hypoplastic uterus, 31.8% with a hypoplastic uterus and hypoplastic ovaries, and 18.2% with ovarian and tubal anomalies. | |||
CONCLUSION: | |||
Combined laparoscopy and hysteroscopy are valuable tools for the diagnosis and classification of female genital system anomalies. | |||
PMID 25552125 | |||
===FOXL2 is a female sex-determining gene in the goat=== | ===FOXL2 is a female sex-determining gene in the goat=== | ||
Curr Biol. 2014 Feb 17;24(4):404-8. doi: 10.1016/j.cub.2013.12.039. Epub 2014 Jan 30. | Curr Biol. 2014 Feb 17;24(4):404-8. doi: 10.1016/j.cub.2013.12.039. Epub 2014 Jan 30. | ||
Revision as of 01:10, 2 March 2015
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Cite this page: Hill, M.A. (2024, May 2) Embryology Genital - Female Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Genital_-_Female_Development |
2015
2014
Combined laparoscopy and hysteroscopy for the detection of female genital system anomalies results of 3,811 infertile women
J Reprod Med. 2014 Nov-Dec;59(11-12):542-6.
Siam S1, Soliman BS.
Abstract
OBJECTIVE: To assess the prevalence of Mullerian and gonadal anomalies in a group of infertile women using a combination of diagnostic laparoscopy and hysteroscopy. STUDY DESIGN: This was a retrospective descriptive study in the setting of a university hospital. The records of 3,811 women who underwent laparoscopy and hysteroscopy for infertility were reviewed. RESULTS: Mullerian duct anomalies (MDAs) were diagnosed in 287/3,811 (7.5%) women, gonadal anomalies in 40/3,811 (1.04%) women, MDAs and gonadal anomalies in 22/3,811 (0.57%) women, and "undefined anomalies" in 8/3,811 (0.2%) women. Among the 287 women with MDAs 54.9% were diagnosed with a septate uterus, 14.2% with an arcuate uterus, 10.2% with a bicornuate uterus, 5.8% with a unicornuate uterus, 4.7% with tubal anomalies, 3.6% with a hypoplastic uterus, 2.9% with Mullerian agenesis, 1.8% with a septate uterus and a double cervix, 1.1% with uterus didelphys, and 0.7% with a longitudinal vaginal septum. Among the 40 women with gonadal anomalies 70% were diagnosed with hypoplastic ovaries, 25% with streak gonads, and 5% with an accessory ovary. Among the 22 women with combined Mullerian and gonadal anomalies 50% were diagnosed with streak gonads and a hypoplastic uterus, 31.8% with a hypoplastic uterus and hypoplastic ovaries, and 18.2% with ovarian and tubal anomalies. CONCLUSION: Combined laparoscopy and hysteroscopy are valuable tools for the diagnosis and classification of female genital system anomalies. PMID 25552125
FOXL2 is a female sex-determining gene in the goat
Curr Biol. 2014 Feb 17;24(4):404-8. doi: 10.1016/j.cub.2013.12.039. Epub 2014 Jan 30.
Boulanger L1, Pannetier M1, Gall L1, Allais-Bonnet A1, Elzaiat M1, Le Bourhis D2, Daniel N1, Richard C1, Cotinot C1, Ghyselinck NB3, Pailhoux E4.
Abstract
The origin of sex reversal in XX goats homozygous for the polled intersex syndrome (PIS) mutation was unclear because of the complexity of the mutation that affects the transcription of both FOXL2 and several long noncoding RNAs (lncRNAs). Accumulating evidence suggested that FOXL2 could be the sole gene of the PIS locus responsible for XX sex reversal, the lncRNAs being involved in transcriptional regulation of FOXL2. In this study, using zinc-finger nuclease-directed mutagenesis, we generated several fetuses, of which one XX individual bears biallelic mutations of FOXL2. Our analysis demonstrates that FOXL2 loss of function dissociated from loss of lncRNA expression is sufficient to cause an XX female-to-male sex reversal in the goat model and, as in the mouse model, an agenesis of eyelids. Both developmental defects were reproduced in two newborn animals cloned from the XX FOXL2(-/-) fibroblasts. These results therefore identify FOXL2 as a bona fide female sex-determining gene in the goat. They also highlight a stage-dependent role of FOXL2 in the ovary, different between goats and mice, being important for fetal development in the former but for postnatal maintenance in the latter. Copyright © 2014 Elsevier Ltd. All rights reserved.
PMID 24485832
