Talk:Developmental Signals - Sox: Difference between revisions
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===Just how conserved is vertebrate sex determination?=== | |||
Dev Dyn. 2013 Feb 6. doi: 10.1002/dvdy.23944. [Epub ahead of print] | |||
Cutting A, Chue J, Smith CA. | |||
Source | |||
Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC. 3052; Department of Paediatrics, University of Melbourne, VIC, 3052, Australia. | |||
Abstract | |||
Sex determination in vertebrate embryos has long been equated with gonadal differentiation into testes or ovaries. This view has been challenged over the years by reports of somatic sexual dimorphisms pre-dating gonadal sex differentiation. The recent finding that sex determination in birds is likely to be cell autonomous has again called for a broader definition of sex determination. The development of sexual identity in each and every cell may apply widely among vertebrates, and may involve more than one "master sex gene" on a sex chromosome. At the gonadal level, key genes required for proper sexual differentiation are conserved among vertebrates, but their relative positions in the ovarian and testicular cascades differ. We illustrate these differences by comparing key sex genes in fishes versus birds and mammals, with emphasis on DM domain genes, the SOX-9AMH pathway in the testis and the FOXL2-Aromatase pathway in the ovary. Such comparisons facilitate the identification of ancient versus derived genes involved in gonadal sex determination. The data indicate that vertebrate sex-determining cascades are not as conserved as once thought. Developmental Dynamics, 2013. © 2013 Wiley Periodicals,Inc. | |||
©2013. Wiley Periodicals, Inc. | |||
PMID 23390004 | |||
===Control of Cell Fate and Differentiation by Sry-related High-mobility-group Box (Sox) Transcription Factors=== | ===Control of Cell Fate and Differentiation by Sry-related High-mobility-group Box (Sox) Transcription Factors=== | ||
Revision as of 18:10, 13 February 2013
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Cite this page: Hill, M.A. (2024, May 24) Embryology Developmental Signals - Sox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Developmental_Signals_-_Sox |
10 Most Recent Papers
Note - This sub-heading shows an automated computer PubMed search using the listed sub-heading term. References appear in this list based upon the date of the actual page viewing. Therefore the list of references do not reflect any editorial selection of material based on content or relevance. In comparison, references listed on the content page and discussion page (under the publication year sub-headings) do include editorial selection based upon relevance and availability. (More? Pubmed Most Recent)
Sox Development
<pubmed limit=5>Sox Development</pubmed>
2013
Just how conserved is vertebrate sex determination?
Dev Dyn. 2013 Feb 6. doi: 10.1002/dvdy.23944. [Epub ahead of print]
Cutting A, Chue J, Smith CA. Source Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC. 3052; Department of Paediatrics, University of Melbourne, VIC, 3052, Australia.
Abstract
Sex determination in vertebrate embryos has long been equated with gonadal differentiation into testes or ovaries. This view has been challenged over the years by reports of somatic sexual dimorphisms pre-dating gonadal sex differentiation. The recent finding that sex determination in birds is likely to be cell autonomous has again called for a broader definition of sex determination. The development of sexual identity in each and every cell may apply widely among vertebrates, and may involve more than one "master sex gene" on a sex chromosome. At the gonadal level, key genes required for proper sexual differentiation are conserved among vertebrates, but their relative positions in the ovarian and testicular cascades differ. We illustrate these differences by comparing key sex genes in fishes versus birds and mammals, with emphasis on DM domain genes, the SOX-9AMH pathway in the testis and the FOXL2-Aromatase pathway in the ovary. Such comparisons facilitate the identification of ancient versus derived genes involved in gonadal sex determination. The data indicate that vertebrate sex-determining cascades are not as conserved as once thought. Developmental Dynamics, 2013. © 2013 Wiley Periodicals,Inc. ©2013. Wiley Periodicals, Inc.
PMID 23390004
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080623/?tool=pubmed
The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators
Lefebvre V. Int J Biochem Cell Biol. 2010 Mar;42(3):429-32. Epub 2009 Jul 30. Review. PMID: 19647094 [PubMed - indexed for MEDLINE]
All purpose Sox: The many roles of Sox proteins in gene expression
Wegner M. Int J Biochem Cell Biol. 2010 Mar;42(3):381-90. Epub 2009 Jul 22. Review. PMID: 19631281 [PubMed - indexed for MEDLINE]
The emerging role of SOX transcription factors in pancreatic endocrine cell development and function
McDonald E, Krishnamurthy M, Goodyer CG, Wang R. Stem Cells Dev. 2009 Dec;18(10):1379-88. Review. PMID: 19725755 [PubMed - indexed for MEDLINE]
The Yin and Yang of Sox proteins: Activation and repression in development and disease
Chew LJ, Gallo V. J Neurosci Res. 2009 Nov 15;87(15):3277-87. Review. PMID: 19437544 [PubMed - indexed for MEDLINE]
Control of chondrogenesis by the transcription factor Sox9
Akiyama H. Mod Rheumatol. 2008;18(3):213-9. Epub 2008 Mar 20. Review. PMID: 18351289 [PubMed - indexed for MEDLINE]
SoxE proteins are differentially required in mouse adrenal gland development
Mol Biol Cell. 2008 Apr;19(4):1575-86. Epub 2008 Feb 13.
Reiprich S, Stolt CC, Schreiner S, Parlato R, Wegner M.
Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany. Abstract Sry-box (Sox)8, Sox9, and Sox10 are all strongly expressed in the neural crest. Here, we studied the influence of these closely related transcription factors on the developing adrenal medulla as one prominent neural crest derivative. Whereas Sox9 was not expressed, both Sox8 and Sox10 occurred widely in neural crest cells migrating to the adrenal gland and in the gland itself, and they were down-regulated in cells expressing catecholaminergic traits. Sox10-deficient mice lacked an adrenal medulla. The adrenal anlage was never colonized by neural crest cells, which failed to specify properly at the dorsal aorta and died apoptotically during migration. Furthermore, mutant neural crest cells did not express Sox8. Strong adrenal phenotypes were also observed when the Sox10 dimerization domain was inactivated or when a transactivation domain in the central portion was deleted. Sox8 in contrast had only minimal influence on adrenal gland development. Phenotypic consequences became only visible in Sox8-deficient mice upon additional deletion of one Sox10 allele. Replacement of Sox10 by Sox8, however, led to significant rescue of the adrenal medulla, indicating that functional differences between the two related Sox proteins contribute less to the different adrenal phenotypes of the null mutants than dependence of Sox8 expression on Sox10.
PMID: 18272785
Back to basics: Sox genes
Kiefer JC. Dev Dyn. 2007 Aug;236(8):2356-66. Review. PMID: 17584862
