Talk:Developmental Mechanisms
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Cite this page: Hill, M.A. (2024, May 9) Embryology Developmental Mechanisms. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Developmental_Mechanisms |
http://www.nature.com/nrg/journal/v7/n4/full/nrg1830.html
2014
Getting to know your neighbor: cell polarization in early embryos
J Cell Biol. 2014 Sep 29;206(7):823-32. doi: 10.1083/jcb.201407064.
Nance J.
Abstract Polarization of early embryos along cell contact patterns--referred to in this paper as radial polarization--provides a foundation for the initial cell fate decisions and morphogenetic movements of embryogenesis. Although polarity can be established through distinct upstream mechanisms in Caenorhabditis elegans, Xenopus laevis, and mouse embryos, in each species, it results in the restriction of PAR polarity proteins to contact-free surfaces of blastomeres. In turn, PAR proteins influence cell fates by affecting signaling pathways, such as Hippo and Wnt, and regulate morphogenetic movements by directing cytoskeletal asymmetries. © 2014 Nance.
PMID 25267293
http://jcb.rupress.org/content/206/7/823.full
The roles and regulation of multicellular rosette structures during morphogenesis
Development. 2014 Jul;141(13):2549-58. doi: 10.1242/dev.101444.
Harding MJ1, McGraw HF2, Nechiporuk A3.
Abstract
Multicellular rosettes have recently been appreciated as important cellular intermediates that are observed during the formation of diverse organ systems. These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. Rosette formation has been studied in various developmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Drosophila epithelium and retina, as well as in the adult neural stem cell niche. These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. By contrast, the extracellular cues that trigger these rearrangements in vivo are less well understood and are more diverse. Here, we review recent studies of the genetic regulation and cellular transitions involved in rosette formation. We discuss and compare specific models for rosette formation and highlight outstanding questions in the field. © 2014. Published by The Company of Biologists Ltd. KEYWORDS: Drosophila epithelium; Morphogenesis; Myosin II; Rosette; Zebrafish lateral line
PMID 24961796
2012
Cilia, calcium and the basis of left-right asymmetry
BMC Biol. 2012 Dec 19;10:102. doi: 10.1186/1741-7007-10-102.
Norris DP. Source Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK. d.norris@har.mrc.ac.uk. Abstract ABSTRACT: The clockwise rotation of cilia in the developing mammalian embryo drives a leftward flow of liquid; this genetically regulated biophysical force specifies left-right asymmetry of the mammalian body. How leftward flow is interpreted and information propagated to other tissues is the subject of debate. Four recent papers have shed fresh light on the possible mechanisms.
PMID 23256866
Extracellular matrix and cytoskeletal dynamics during branching morphogenesis
Organogenesis. 2012 Apr-Jun;8(2):56-64. doi: 10.4161/org.19813. Epub 2012 Apr 1.
Kim HY, Nelson CM. Source Department of Chemical and Biological Engineering, Princeton University; Princeton, NJ USA.
Abstract
Branching morphogenesis is a fundamental developmental process which results in amplification of epithelial surface area for exchanging molecules in organs including the lung, kidney, mammary gland and salivary gland. These complex tree-like structures are built by iterative rounds of simple routines of epithelial morphogenesis, including bud formation, extension, and bifurcation, that require constant remodeling of the extracellular matrix (ECM) and the cytoskeleton. In this review, we highlight the current understanding of the role of the ECM and cytoskeletal dynamics in branching morphogenesis across these different organs. The cellular and molecular mechanisms shared during this morphogenetic process provide insight into the development of other branching organs. PMID 22609561
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429513/
http://www.landesbioscience.com/journals/organogenesis/article/19813/?nocache=1100256833
2011
The bending of cell sheets--from folding to rolling
BMC Biol. 2011 Dec 29;9:90. Keller R, Shook D. Source Department of Biology, 241 Gilmer Hall, University of Virginia, Charlottesville, VA 22904, USA. rek3k@virginia.edu
Abstract
The bending of cell sheets plays a major role in multicellular embryonic morphogenesis. Recent advances are leading to a deeper understanding of how the biophysical properties and the force-producing behaviors of cells are regulated, and how these forces are integrated across cell sheets during bending. We review work that shows that the dynamic balance of apical versus basolateral cortical tension controls specific aspects of invagination of epithelial sheets, and recent evidence that tissue expansion by growth contributes to neural retinal invagination in a stem cell-derived, self-organizing system. Of special interest is the detailed analysis of the type B inversion in Volvox reported in BMC Biology by Höhn and Hallmann, as this is a system that promises to be particularly instructive in understanding morphogenesis of any monolayered spheroid system. © 2011 Keller and Shook; licensee BioMed Central Ltd.
PMID 22206439
