Talk:Abnormal Development - Toxoplasmosis: Difference between revisions
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PMID: 21185786 | PMID: 21185786 | ||
===Knowledge of Toxoplasmosis among Doctors and Nurses Who Provide Prenatal Care in an Endemic Region=== | |||
Infect Dis Obstet Gynecol. 2011;2011:750484. Epub 2011 May 18. | |||
da Silva LB, de Oliveira Rde V, da Silva MP, Bueno WF, Amendoeira MR, de Souza Neves E. | |||
Source | |||
Laboratório de Doenças Febris Agudas, Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz, Avenida Brasil 4365, 21040-360 Rio de Janeiro, RJ, Brazil. | |||
Abstract | |||
Congenital toxoplasmosis is a potentially severe infection and its prevention is most often based on serological screening in pregnant women. Many cases could be prevented by simple precautions during pregnancy. Aiming to assess the knowledge about toxoplasmosis among professionals working in antenatal care in a high prevalent region, a questionnaire was administered to 118 obstetric nurses and physicians attending at primary care units and hospitals. The questionnaire was self-completed and included questions on diagnosis, clinical issues, and prevention. Only 44% of total answers were corrected. Lower scores were observed among those with over 10 years of graduation, working in primary care units, and nurses. Errors were mainly observed in questions of prevention and diagnosis. As congenital toxoplasmosis is a mother-to-child (MTC) transmitted disease, early diagnosis and treatment can prevent serious and irreversible fetal damage. Thus, doctors and nurses who provide prenatal care must be appropriately trained on prophylactic, diagnostic, and clinical aspects of toxoplasmosis. The authors suggest that measures should be taken for continuing education regarding toxoplasmosis in pregnancy. | |||
PMID: 21747644 | |||
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124125 | |||
Revision as of 16:07, 25 July 2011
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Cite this page: Hill, M.A. (2024, April 27) Embryology Abnormal Development - Toxoplasmosis. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Toxoplasmosis |
2011
Toxoplasmosis and horse meat, france
Emerg Infect Dis. 2011 Jul;17(7):1327-8.
Pomares C, Ajzenberg D, Bornard L, Bernardin G, Hasseine L, Darde ML, Marty P. Source Universite de Nice-Sophia Antipolis-Inserm U895, Nice, France. Abstract To the Editor: Toxoplasma gondii parasites are obligate intracellular apicomplexans that can infect virtually all warm-blooded animals; felids are definitive hosts. The most common sources of human infection are ingestion of tissue cysts in undercooked meat or of food or water contaminated with oocysts shed by felids and transplacental transmission. Acquired toxoplasmosis in immunocompetent humans is frequently asymptomatic but is associated with cervical or occipital lymphadenopathy in approximately 10% of patients. Severe or fatal outcomes for immunocompetent patients have been attributed to the virulence of specific T. gondii genotypes (1). We describe 3 cases of toxoplasmosis caused by atypical strains probably acquired by from ingestion of raw horse meat imported from Canada and Brazil.
PMID: 21762609
Clin Immunol. 2011 Feb;138(2):129-34. Epub 2010 Dec 24.
Robert-Gangneux F, Gangneux JP, Vu N, Jaillard S, Guiguen C, Amiot L. Source Laboratoire de Parasitologie, Faculté de Médecine et Centre Hospitalier Universitaire de Rennes, Rennes, France. florence.robert-gangneux@univ-rennes1.fr Abstract The expression of human leukocyte antigen (HLA)-G on cytotrophoblast cells contributes to maternal-fetal tolerance. Soluble forms of HLA-G (sHLA-G) can be detected in amniotic fluid (AF) and a decrease of sHLA-G is known to be correlated to fetal loss. In this work we investigated the role of sHLA-G in the transplacental passage of the protozoan parasite Toxoplasma gondii, responsible for congenital toxoplasmosis in about 30% of fetuses when primary infection (PI) occurs during pregnancy. We determined the sHLA-G concentration in 61 AF from women with PI and 24 controls. Our results showed higher sHLA-G levels in AF from PI than in controls (p<0.001). Moreover sHLA-G level from congenitally infected fetuses (n=12) was higher than in fetus in whom congenital infection was ruled out (n=49, p<0.05). These data suggest that sHLA-G could participate in immunomodulation necessary to avoid fetal loss due to Toxoplasma infection, but that over-expression could favor congenital transmission.
Copyright © 2010 Elsevier Inc. All rights reserved.
PMID: 21185786
Knowledge of Toxoplasmosis among Doctors and Nurses Who Provide Prenatal Care in an Endemic Region
Infect Dis Obstet Gynecol. 2011;2011:750484. Epub 2011 May 18.
da Silva LB, de Oliveira Rde V, da Silva MP, Bueno WF, Amendoeira MR, de Souza Neves E. Source Laboratório de Doenças Febris Agudas, Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz, Avenida Brasil 4365, 21040-360 Rio de Janeiro, RJ, Brazil.
Abstract
Congenital toxoplasmosis is a potentially severe infection and its prevention is most often based on serological screening in pregnant women. Many cases could be prevented by simple precautions during pregnancy. Aiming to assess the knowledge about toxoplasmosis among professionals working in antenatal care in a high prevalent region, a questionnaire was administered to 118 obstetric nurses and physicians attending at primary care units and hospitals. The questionnaire was self-completed and included questions on diagnosis, clinical issues, and prevention. Only 44% of total answers were corrected. Lower scores were observed among those with over 10 years of graduation, working in primary care units, and nurses. Errors were mainly observed in questions of prevention and diagnosis. As congenital toxoplasmosis is a mother-to-child (MTC) transmitted disease, early diagnosis and treatment can prevent serious and irreversible fetal damage. Thus, doctors and nurses who provide prenatal care must be appropriately trained on prophylactic, diagnostic, and clinical aspects of toxoplasmosis. The authors suggest that measures should be taken for continuing education regarding toxoplasmosis in pregnancy.
PMID: 21747644
