Difference between revisions of "Intermediate - Primordial Heart Tube"

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[[Image:HeartILP_draft_heartlayers.jpg|thumb|center|upright=2|Cross-section through the ventricular section of the heart tube]]
 
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|width="30%" bgcolor="gold"|<big>'''[[Intermediate_Cardiac_Embryology|Back to the intermediate homepage]]'''</big>
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|width="30%" bgcolor="gold" align="right"|<big>'''[[Intermediate_-_Heart_Tube_Looping|Next: Looping of the Heart Tube]]'''</big>
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|bgcolor="limegreen"|<big>'''[[Basic_-_Primitive_Heart_Tube|Go to this section in the basic level]]'''</big>
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Revision as of 09:24, 14 October 2009

Intermediateicon.jpg
Begin Intermediate: Primordial Heart Tube  Heart Tube Looping  Atrial Ventricular Septation  Outflow Tract  Heart Valves  Cardiac Abnormalities  Vascular Overview


Cardiac Embryology     Begin Basic     Begin Intermediate     Begin Advanced  


The heart primordium arises predominantly from splanchnic mesoderm in the cardiogenic region of the trilaminar embryo. The cardiogenic region can be thought of as bilateral fields that merge cranially to form a horseshoe shaped field. During the third week of development (approximately day 18), angioblastic cords develop in this cardiogenic mesoderm and canalise to form bilateral heart tubes.

Dorsal view of 18 day embryo
File:HeartILP draft HeartTubeLateral.jpg
Lateral view of 18 day embryo

Lateral folding of the embryo brings the heart tubes into the ventral midline allowing them to fuse to form a single primordial heart tube. Fusion of the heart tubes begins cranially and extends caudally and is facilitated by apoptosis. The animation below shows a cross section of the embryo, the development of the endocardial heart tubes as well as their migration and fusion in the midline.


<Flowplayer height="540" width="720" autoplay="true">Heart folding 003.flv</Flowplayer>


File:HeartILP draft brightfieldtubefusion.jpg
Brightfield images showing fusion of the heart tubes and the earliest appearance of segments of the fused heart tube
Early divisions of the heart tube

After fusion constrictions and dilations appear in the heart tube forming the following divisions:

  • Truncus arteriosus
  • Bulbus cordis
  • Primordial ventricle
  • Primordial atrium
  • Sinus venosus

Note that by the end of the fourth week (day 22), coordinated contractions of the heart tube are present and push blood cranially from the sinus venosus. In the previous animation, you saw that the dorsal aortae developed concurrently with the endocardial heart tubes and form a cranial connection with the endocardial heart tubes prior to folding. As the embryo folds the cranial ends of the dorsal aortae are pulled ventrally until they form a dorsoventral loop, the first aortic arch arteries. The embryonic vascular system is discussed in further detail here.

Heart Layers

Myocardium: forms from splanchnic mesoderm surrounding the pericardial coelom. Additional myocardial cells are added to the outflow tract during heart looping.

Cardiac Jelly: gelatinous connective tissue separating the myocardium and heart tube endothelium.

Endocardium: forms from the endothelium of the heart tube.

Epicardium: develops from mesothelial cells arising from the sinus venosus which spread cranially over the myocardium.


File:HeartILP draft heartlayers.jpg
Cross-section through the ventricular section of the heart tube


Back to the intermediate homepage Next: Looping of the Heart Tube
Go to this section in the basic level Go to this section in the advanced level