Immune System Development

Introduction

Development of the immune system will also link to both blood and cardiovascular development notes on vessel development.

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Some Recent Findings

Regulation of lymphatic-blood vessel separation by endothelial Rac1. "Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown." Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways."Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway." Epithelial cells in fetal intestine produce chemerin to recruit macrophages. "Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens."

References

Search Pubmed

Search August 2010 "Immune System Development" All (90551) Review (15955) Free Full Text (28278)

Search Pubmed: Immune System Development | Embryo Immune System Development

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Cite this page: Hill, M.A. (2024, April 30) Embryology Immune System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Immune_System_Development

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G