Genetic risk maternal age: Difference between revisions

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* Hook EB. Rates of chromosome abnormalities at different maternal ages. Obstetrics and Gynecology 58:282-285, 1981 (Data USA sourced)  
* Hook EB. Rates of chromosome abnormalities at different maternal ages. Obstetrics and Gynecology 58:282-285, 1981 (Data USA sourced)  
[http://www.ncbi.nlm.nih.gov/pubmed/6455611 PMID: 6455611]
* Hook EB, Cross PK, Schreinemachers DM. Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA. 1983 Apr 15;249(15):2034-8. [http://www.ncbi.nlm.nih.gov/pubmed/6220164 PMID: 6220164]
* Hook EB, Cross PK, Schreinemachers DM. Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA. 1983 Apr 15;249(15):2034-8. [http://www.ncbi.nlm.nih.gov/pubmed/6220164 PMID: 6220164]
* Schreinemachers DM, Cross PK, Hook EB. Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births. Hum Genet. 1982;61(4):318-24. [http://www.ncbi.nlm.nih.gov/pubmed/6891368 PMID: 6891368]
* Schreinemachers DM, Cross PK, Hook EB. Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births. Hum Genet. 1982;61(4):318-24. [http://www.ncbi.nlm.nih.gov/pubmed/6891368 PMID: 6891368]


==Glossary Links==
==Glossary Links==

Revision as of 17:43, 24 March 2010

The table below shows the correlation of maternal age (mother's age) and the potential risk of human genetic abnormalities in children.

The first column shows maternal age, the second column shows the most common human chromosomal abnormality, trisomy 21 (Down syndrome), the third column shows all chromosomal abnormalities.


Age of Mother
Risk of Down Syndrome
Risk of Any Chromosomal Abnormality
20
1 in 1667
1 in 526
21
1 in 1667
1 in 526
22
1 in 1429
1 in 500
23
1 in 1429
1 in 500
24
1 in 1250
1 in 476
25
1 in 1250
1 in 476
26
1 in 1176
1 in 476
27
1 in 1111
1 in 455
28
1 in 1053
1 in 435
29
1 in 1000
1 in 417
30
1 in 952
1 in 384
31
1 in 909
1 in 384
32
1 in 769
1 in 323
33
1 in 625
1 in 286
34
1 in 500
1 in 238
35
1 in 385
1 in 192
36
1 in 294
1 in 156
37
1 in 227
1 in 127
38
1 in 175
1 in 102
39
1 in 137
1 in 83
40
1 in 106
1 in 66
41
1 in 82
1 in 53
42
1 in 64
1 in 42
43
1 in 50
1 in 33
44
1 in 38
1 in 26
45
1 in 30
1 in 21
46
1 in 23
1 in 16
47
1 in 18
1 in 13
48
1 in 14
1 in 10
49
1 in 11
1 in 8

References

  • Hook EB. Rates of chromosome abnormalities at different maternal ages. Obstetrics and Gynecology 58:282-285, 1981 (Data USA sourced)

PMID: 6455611

  • Hook EB, Cross PK, Schreinemachers DM. Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA. 1983 Apr 15;249(15):2034-8. PMID: 6220164
  • Schreinemachers DM, Cross PK, Hook EB. Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births. Hum Genet. 1982;61(4):318-24. PMID: 6891368

Glossary Links

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Dr Mark Hill 2009, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G