File:Zebrafish ectodermal patterning model.jpg

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Two-step model for zebrafish ectodermal patterning

Step 1 depicts the DV gradient present during gastrulation. High BMP activity is observed ventrally as generated by bmp2b/4/7a ligand expression and reinforced by Cvl2. BMP activity is inhibited dorsally by expression of the diffusible antagonists Chordin and Noggin. Prospective PPE and NC are formed at intermediate levels of BMP signalling.

Step 2 the initial gradient has reshaped into distinct BMP activity domains during neurulation. The regulatory network is depicted. Components in black act positively, whereas those in red act negatively. NC, neural crest; PPE, preplacodal ectoderm.


Links: gastrulation | BMP | WNT | NOGGIN | NODAL

Reference

Reichert S, Randall RA & Hill CS. (2013). A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development , 140, 4435-44. PMID: 24089471 DOI.

Copyright

© 2013. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.


Cite this page: Hill, M.A. (2024, April 24) Embryology Zebrafish ectodermal patterning model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Zebrafish_ectodermal_patterning_model.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current22:44, 3 March 2015Thumbnail for version as of 22:44, 3 March 20151,280 × 662 (80 KB)Z8600021 (talk | contribs)A two-step model for zebrafish ectodermal patterning. Step 1 depicts the DV gradient present during gastrulation. High BMP activity is observed ventrally as generated by bmp2b/4/7a ligand expression and reinforced by Cvl2. BMP activity is inhibited dor...

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